healthcare applications and robotics. [5][6][7] Organic electrochemical transistors (OECTs) are the building blocks of many of the most sensitive sensors. [8,9] Unlike conventional field effect transistors (FETs), OECTs consist of an active layer with mixed electronic and ionic transport, enabling remarkably high transconductance (g m ) for high amplification of signals. [10,11] For example, OECT-based devices for electrophysiological recording with high signal integrity, [8,9,12] highly sensitive biosensors, [13][14][15][16] neuromorphic applications, [17] display drivers, [18] and optical logic gates [19] have been reported. However, practical applications of OECTs critically rely on the development of devices with a high transconductance at high strain (≈100%) to accommodate for the dynamic range of motions and shapes of the human body. [20] The breakdown of high transconductance typically stems from the high resistance of the source/drain electrodes at high strain. Electrodes must be highly conductive at high strain, stable in the electrolyte, and soft enough to avoid stress concentration at the interface with the active layer. [21,22] While there have been reports of highly conductive stretchable conductors (Ag-based materials, carbon nanotubes, and liquid metals [3,[23][24][25][26][27] ), there has yet been a demonstration of a stretchable conductor which collectively satisfies the aforementioned requirements. Importantly, plain Au thin films are not stretchable while Au thin films with microcrack morphology are stretchable and electrolyte-stable. [28][29][30][31][32] However, the conductance at high strain (≈100%) was not ideal, with sheet resistance increasing over two orders of magnitude observed due to the large strain-induced microcrack propagation. This large microcrack propagation originates from the uncontrolled morphology of initial microcracks in as-deposited Au thin films. We propose that control over the initial microcrack morphology and propagation may lead to improved and stable conductance at high strains.Here, we report highly stretchable (≈140%) and hightransconductance (>0.1 mS) OECTs, enabled by microcracked Au conductors engineered by programming the initial microcrack formation (Figure 1a). Inspired by kirigami-structures, we hypothesized that highly stretchable Au can be obtained if the High-transconductance stretchable transistors are important for conformable and sensitive sensors for wearables and soft robotics. Remarkably high transconductance, which enables large amplification of signals, has been achieved through the use of organic electrochemical transistors (OECTs). However, the stretchability of such systems has been tempered by the lack of stretchable conductors with high stability in electrolytes, high conductance at high strain (100%), and process compatibility with active layers. Highly stretchable and strain-resistant Au conductors employed to fabricate intrinsically stretchable OECTs are demonstrated. Notably, the conductors exhibit a sheet resistance of 33.3 Ω Sq. −1 at...