Light-sensitive dextran-covered PNBA nanoparticles to continuously or discontinuously improve the drug release

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

“…The PAMs have hydrophobic characteristics, i.e., the apolar segment of the produced amphiphilic polymer or the hydrophobic/hydrophilic bridge-like segments (hydrophobic-b-hydrophilic) (Figure 1(Aa)) [138]. This polymer amphiphilicity may lead to various PMNs-such as nanomicelles [139] (Figure 2B), nanopolymersomes [140] (Figure 2C), and nanospheres [141]using nanoprecipitation [142], nanoemulsion [143], crosslinking [144], and layer-bylayer [145] techniques for their assembly (Figure 1(Ab)). For example, Perez-Buitrago et al synthesized a photoisomerizable poly2-[4-phenylazophenoxy]ethyl acrylate-coacrylic acid (PPAPE) amphiphilic copolymer, functionalizing an azobenzene molecule (Table 1A), modified with a terminal hydroxyl group with an acryloyl chloride polymer via nucleophilic substitution.…”

Spatio-temporal control over destabilization of Pickering emulsions stabilized by light-sensitive dextran-based nanoparticles

“…Thus, under irradiation, NBA units are photo-cleaved to release nitrosobenzaldehyde (NSBZ) and to generate acrylic acid units (AA) on the grafts (Figure S15). Soliman et al showed that these AA units could be deprotonated in presence of phosphate buffer saline (PBS) (Soliman et al, 2019). This dramatically increased their solubility in water so that irradiated Dex-g-(NBA-co-AA) chains became also much more soluble, leading to the destabilization of the nanoparticles.…”

“…They were then able to elaborate nanoparticles via nanoprecipitation. They observed that the photo-cleavage of PNBA to produce Poly(Acrylic Acid) (PAA) led, at a higher scale, to the photolysis of the PNBA grafted dextran (Dex-g-PNBA) nanoparticles (El Founi et al, 2018;Soliman, 2018;Soliman et al, 2019). As another example, the use of PNBA as surface modifier of stabilizing cellulose nanocrystals has been recently presented in the work of Tajmoradi et al (Tajmoradi et al, 2021).…”

Self-assembly of amphiphilic copolymers containing polysaccharide: PISA versus nanoprecipitation, and the temperature effect

“…[1][2][3][4][5][6] For many decades, the self-assembly of AGPs in water has been induced via "conventional assembly processes", 6,7 including nanoprecipitation, [8][9][10][11][12][13][14] and emulsion-solvent evaporation. [15][16][17][18][19][20][21][22] Namely, in these pathways, pre-synthesized amphiphilic copolymers are initially dissolved in a common organic solvent for both blocks followed by a gradual addition of water, a selective solvent for one of the blocks, to induce the formation of nanoobjects. Although such processes are relatively simple to perform at the laboratory scale, their industrial transposition is limited due to the low solids concentration (typically <1 %wt) prepared and the multiple processing and purification steps required.…”