Polymers containing o-nitrobenzyl esters are promising for preparation of light sensitive materials. o-Nitrobenzyl methacrylate has already been polymerized by controlled ATRP or RAFT. Unfortunately, the radical polymerization of o-nitrobenzyl acrylate (NBA) was not controlled until now due to inhibition and retardation effects coming from the nitro-aromatic groups. Recent developments in the Single Electron TransferLiving Radical Polymerization (SET-LRP) provide us an access to control this NBA polymerization and living character of this NBA SET-LRP is demonstrated. Effects of CuBr 2 and ligand concentrations, as well as Cu(0) wire length on SET-LRP kinetics are shown presently. A first-order kinetics with respect to the NBA concentration is observed after one induction period. SET-LRP proceeds with a linear evolution of molecular weight and a narrow distribution. High initiation efficiency close to 1 and high chain-end functionality (93%) are reached. Chain extension of poly(o-nitrobenzyl acrylate) is realized with methyl acrylate (MA) to obtain well defined poly(o-nitrobenzyl acrylate)-b-poly(methyl acrylate) (PNBA-b-PMA). Finally, lightsensitive properties of PNBA are checked upon UV irradiation.
Whatever the process, the photosensitive property and the colloidal stability of NPs in the presence of salts were proved. However, triazole rings between the dextran shell and the PNBA core avoid the dextran shell desorption in the presence of SDS. NPs' biocompatibility towards Caco-2 was proved and 100% cell viability was still observed after exposure to NPs following by 60 s UV-irradiation.
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