Light‐Programmable Nanocomposite Hydrogel for State‐Switchable Wound Healing Promotion and Bacterial Infection Elimination

Abstract

Developing an ideal wound dressing that not only accelerates wound healing but also eliminates potential bacterial infections remains a difficult balancing act. This work reports the design of a light-programmable sodium alginate nanocomposite hydrogel loaded with BiOCl/polypyrrole (BOC/PPy) nanosheets for state-switchable wound healing promotion and bacterial infection elimination remotely. The nanocomposite hydrogel possesses programmable photoelectric or photothermal conversion due to the expanded light absorption range, optimized electron transmission interface, promoted photo-generated charge separation, and transfer of the BOC/PPy nanosheets. Under white light irradiation state, the nanocomposite hydrogel induces human umbilical vein endothelial cells migration and angiogenesis, and accelerates the healing efficiency of mouse skin in vivo. Under near-infrared light irradiation state, the nanocomposite hydrogel presents superior antibacterial capability in vitro, and reaches an antibacterial rate of 99.1% for Staphylococcus aureus infected skin wound in vivo. This light-programmable nanocomposite hydrogel provides an on-demand resolution of biological state-switching to balance wound healing and elimination of bacterial infection.

Traditional Herb (Moxa) Modified Zinc Oxide Nanosheets for Quick, Efficient and High Tissue Penetration Therapy of Fungal Infection

“…Specifically, CMZ contained typical absorption peaks at 3447, 2920, and 1110 cm –1 , corresponding to hydroxyl, hydrocarbon and ether bonds respectively, which was consistent with the description in the literature (Figure d) . The band structure determines the optical absorption performance of the material . Compared with ZnO (2.80 eV), CMZ had a narrower bandgap of about 2.00 eV, indicating that the addition of CM (1.25 eV) was beneficial for reducing the bandgap (Figures e and S3b).…”

Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On‐Demand Removability for Wound Closure and MRSA‐Infected Wound Healing

“…The experiment of 1 H‐NMR, FTIR, SEM, self‐healing, [ 28 ] rheological properties, [ 29 ] tissue adhesion, [ 11 ] in vitro burst pressure test, [ 23 ] biocompatibility, [ 30 ] antioxidant capacity, [ 31 ] in vivo hemostasis testing, [ 32 ] in vitro NIR‐assisted antibacterial assay, [ 33 ] in vivo host response evaluation, [ 34 ] and in vivo studies of subcutaneous infection [ 35 ] were all performed according to the previous studies. The experimental details are shown in the Supporting Information.…”

Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

“…1,2 However, both trauma and physiological environment can cause harm to skin tissue, making skin wounds become a common healthcare problem. 3,4 Skin usually exhibits excellent regenerative properties, and normal skin wound healing involves a series of highly ordered processes including hemostasis, inammation, proliferation, and extracellular matrix (ECM) remodeling, [5][6][7][8] as shown in Fig. 1.…”