Light microscopy and magnetic resonance characterization of a DMSA-coated magnetic fluid in mice

Chaves, Sacha Braun; Lacava, L.M.; Lacava, Z.G.M.; Silva, O.; Pelegrini, F.; Buske, N.; Gansau, C.; Morais, P.C.; Azevedo, Ricardo Bentes

doi:10.1109/tmag.2002.802495

Cited by 46 publications

(38 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of such bands suggests that DMSA molecules were bound to Fe 3þ ions located in the particle surface via COO À groups [1]. As previously reported, this surface functionalization with DMSA provides the opportunity to target the accumulation of synthesized MNPs-DMSA specifically to the lung [2,5].…”

Section: Characterization Of Magnetic Nanoparticlessupporting

confidence: 61%

“…The efficiency of clinical treatment based on MNPs depends upon the ability of these particles to accumulate at specific sites in the body. MNPs surface-functionalized with meso-2,3-dimercaptosuccinic acid (MNPs-DMSA) present preferential distribution for the lung from 5 min up to 24 h after intravenous administration [2]. This target specificity of MNPs-DMSA offers a unique property which may be successfully exploited for the treatment of lung diseases, in that comparably high doses of drugs can be delivered to the lung without increasing side effects in extrapulmonary organs [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a β2 integrin-dependent pathway

et al. 2010

View full text Add to dashboard Cite

Section: Characterization Of Magnetic Nanoparticlessupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a β2 integrin-dependent pathway

et al. 2010

View full text Add to dashboard Cite

“…In recent years, the design and synthesis of nanometer-scaled particles have been the focus of intense fundamental and applied research, with special emphasis on their unusual properties and promising new possibilities in the biomedical area [2]. A dextran-coated magnetite-based MF sample (DexMF) was developed for cancer diagnostic and therapeutic purposes.…”

mentioning

confidence: 99%

“…The liver and spleen were collected from animals (N ¼ 3) submitted to perfusion procedure at 1 h, 1, 2, 7, and 28 days, and 3 and 6 months after DexMF administration. The collected organs were fixed, stained with Hematoxylin & Eosin (H&E) or Perl's reaction (Prussian blue reaction), and analyzed using light microscopy, as described elsewhere [2,6].…”

mentioning

confidence: 99%

Long-term retention of dextran-coated magnetite nanoparticles in the liver and spleen

Lacava

Garcia

Kückelhaus

et al. 2004

Journal of Magnetism and Magnetic Materials

Self Cite

View full text Add to dashboard Cite

“…Therefore, the impact and interaction of nanoparticles with cells and tissues of animals will be different [13].…”

Section: Introductionmentioning

confidence: 99%

Influence of Titanium Dioxide Nanoparticles on Oxidative Stress and Pulmonary Dysfunction

Doudi

Setorki

2015

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: Given the high application rate of titanium dioxide (TiO 2 ) nanoparticles in various industries and importance of the liver in body detoxification, the present study reviewed the toxic effects of such nanoparticles on changes of hepatic enzymes and liver and lung tissues. Materials and Methods: In this experimental study, 32 Wistar rats were randomly divided into 4 groups: control (treated with 0.5 mL normal saline) and three experimental groups. Group 1, 2, and 3 received 0.5 mL of solution containing 10, 100, and 300 ppm TiO 2 for 7 successive days, respectively. The effects of nanoparticles on serum levels of glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT) were evaluated at 2, 7, and 14 days. After 14 days, the tissue of liver and lung was collected and investigated. Results: Mean SGOT levels, two days after the intervention, in groups 1 and 3 were significantly greater than the control group. Group 3 had a higher toxicity on hepatic enzymes. The histological results of liver in group 1 showed hepatocyte vasculature and hypertrophy approximate and elimination of hepatic lobules, in group 2 showed, decreased effect of hepatocyte acidophilic and elimination of hepatic lobules, and in group 3 showed, shrinkage of central veins and immediate hyperemia. The histological results in lung, also, showed destruction of alveolus (group 1) and vasculature hyperemia in all groups. Conclusions: It can be concluded that nanometer spherical-shaped TiO 2 nanoparticles, even in small amounts for medical purposes, causes cell toxicity. Further research is needed in order to study its effects on organs and blood factors.

show abstract

Light microscopy and magnetic resonance characterization of a DMSA-coated magnetic fluid in mice

Cited by 46 publications

References 8 publications

The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a β2 integrin-dependent pathway

The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a β2 integrin-dependent pathway

Long-term retention of dextran-coated magnetite nanoparticles in the liver and spleen

Influence of Titanium Dioxide Nanoparticles on Oxidative Stress and Pulmonary Dysfunction

Contact Info

Product

Resources

About