Light‐Induced Content Release from Plasmon‐Resonant Liposomes

Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

“…Using AuNPs to control liposome leakage has been extensively studied. 37,74 3) Finally, these systems are useful for understanding fundamental interaction mechanisms of nanomaterials with biological membranes.…”

Fiber-optic triggered release of liposome in vivo: implication of personalized chemotherapy

“…(DSPC:DPPC), or 80:20 (DPPC:Chol), were tethered with AuNPs up to 132 ng/mL for exploring the optimal photoresponsive liposome for the fiber-optic guided laser triggered release study. 17,26,27,[39][40][41][42] The 90:10:4 (DPPC:MPPC:DSPEPEG2k) liposome with 33 ng/mL AuNPs achieved the strongest photo-thermal conversion efficiency while maintaining decent liposome integrity at physiological temperature without causing significant leakage (21.92%±2.08% in 40 minutes without excitation) as shown in Figure 6. The AuNP-incorporated liposomes were spherical in shape with AuNPs appearing as black dots floating on the surface, and had a uniform particle size distribution, primarily around 100 nm, as observed by TEM ( Figure 4B).…”

“…Because of their proven biocompatibility and efficient photo-thermal conversion through surface plasma resonance, AuNPs (cluster, nanoshell) have previously been deposited on the liposome membrane outer surface, tethered to the liposome membrane, or entrapped within the liposome cavity for remotely triggered content release through wavelength-specific light excitation from the ultraviolet to near infrared region. [39][40][41][42] However, no studies have reported their corresponding content release efficiencies triggered by light excitation in vivo. This may be due to challenges caused by the inconsistent results of in vivo non-invasive irradiation from varying subject/disease conditions (such as tumor size and location).…”

Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity

“…Here, the leading approach involves coating of liposomebased delivery platform with gold nanostructures. [16][17][18][19] In this scenario, liposomes illuminated with laser light (NIR lasers in most cases) experience a temperature rise causing a phase transition in the lipids, which induces drug release. In addition, the same gold nanostructures may enable photothermal therapy (PPT) of cancer.…”