Light/gas cascade-propelled Janus micromotors that actively overcome sequential and multi-staged biological barriers for precise drug delivery

Zhou, Xiang; Huang, Xiuhong; Wang, Bincheng; Tan, Lihui; Zhang, Yi; Jiao, Yanpeng

doi:10.1016/j.cej.2020.127897

Cited by 45 publications

(30 citation statements)

References 38 publications

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“…The development of microcapsule-based autonomous artificial micro/nanomotors has gained considerable attention because of their potential in various application fields. [455][456][457] These tiny ''engines'' can be powered by various forms of energy from chemical reactions and physical triggers including, light, heat, electric, ultrasound or magnetic fields. 458,459 He and coworkers 460 fabricated a fuel-free, near-infrared (NIR)-driven Janus microcapsule motor with a maximum speed of 42 mm s À1 in water via a template-assisted polyelectrolyte layer-by-layer assembly, followed by spraying of a gold layer on one side.…”

Section: Perfume Fragrance and Cosmeticsmentioning

confidence: 99%

A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules

Parakhonskiy

Skirtach

2023

Chem. Commun.

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Section: Perfume Fragrance and Cosmeticsmentioning

confidence: 99%

A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules

Parakhonskiy

Skirtach

2023

Chem. Commun.

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“…The propulsive force helps MNRs to traverse biological barriers such as the dense extracellular matrix, blood-brain barrier, and blood-tumor barrier in an autonomous manner (Joseph et al, 2017;, rather than passively circulating through blood flow. The tumor-targeted delivery capability of MNRs can effectively improve drug bioavailability and reduce the required drug dose to minimize side effects (Alapan et al, 2020;Zhou et al, 2021). In the following part, we classify and demonstrate the MNRs with different driving mechanisms according to the power source.…”

Section: Micro/nanorobotsmentioning

confidence: 99%

“…Successive biological barriers, as one of the challenges, could hinder the application of tumor therapy. Zhou et al recently reported that Janus calcium carbonate particle micromotors (JCPMs) could achieve precise drug (i.e., DOX) delivery via a multistage self-adapted strategy that combines NIR-light driven navigation, photothermal cytomembrane traversing, autonomous tumor penetration, and microenvironment triggered CO 2 -propulsion in a cascaded manner to overcome sequential biological barriers (Zhou et al, 2021) (Figure 8F). The notable mobile ability of JCPMs comes from the selfthermophoretic force and thermomechanical perforation of the cytomembrane by the photothermal effect and the CO 2 generation of CaCO 3 -based JCPMs under an acidic lysosomal microenvironment.…”

Section: Nir Lightmentioning

confidence: 99%

“Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy

Zhang

Liu

Guan

et al. 2022

Front. Bioeng. Biotechnol.

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Traditional drug delivery systems opened the gate for tumor-targeted therapy, but they generally took advantage of enhanced permeability and retention or ligand-receptor mediated interaction, and thus suffered from limited recognition range (<0.5 nm) and low targeting efficiency (0.7%, median). Alternatively, micro/nanorobots (MNRs) may act as emerging “motile-targeting” drug delivery platforms to deliver therapeutic payloads, thereby making a giant step toward effective and safe cancer treatment due to their autonomous movement and navigation in biological media. This review focuses on the most recent developments of MNRs in “motile-targeting” drug delivery. After a brief introduction to traditional tumor-targeted drug delivery strategies and various MNRs, the representative applications of MNRs in “motile-targeting” drug delivery are systematically streamlined in terms of the propelling mechanisms. Following a discussion of the current challenges of each type of MNR in biomedical applications, as well as future prospects, several promising designs for MNRs that could benefit in “motile-targeting” drug delivery are proposed. This work is expected to attract and motivate researchers from different communities to advance the creation and practical application of the “motile-targeting” drug delivery platforms.

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“…[36,37] Additionally, the subsequent laser irradiation could improve their motion performance, resulting in the lysosome escape. [38] Since mitochondria act as energy supply factories in cells and participate in the regulation of apoptosis, mitochondrial phototherapy has been considered a promising strategy for cancer treatment. [39] To evaluate the colocalization of mitochondria and photosensitizers, IM-treated cells were stained with MitoTracker Green.…”

Section: Locomotory Activity Tissue Uptake and Cellular Uptake Of Npsmentioning

confidence: 99%

Near‐Infrared‐Enpowered Nanomotor‐Mediated Targeted Chemotherapy and Mitochondrial Phototherapy to Boost Systematic Antitumor Immunity

Xiao

2022

Adv Healthcare Materials

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Phototherapy is an important strategy to inhibit tumor growth and activate antitumor immunity. However, the effect of photothermal/photodynamic therapy (PTT/PDT) is restricted by limited tumor penetration depth and unsatisfactory potentiation of antitumor immunity. Here, a near‐infrared (NIR)‐driven nanomotor is constructed with a mesoporous silicon nanoparticle (MSN) as the core, end‐capped with Antheraea pernyi silk fibroin (ApSF) comprising arginine–glycine–aspartate (RGD) tripeptides. Upon NIR irradiation, the resulting ApSF‐coated MSNs (DIMs) loading with photosensitizers (ICG derivatives, IDs) and chemotherapeutic drugs (doxorubicin, Dox) can efficiently penetrate into the internal tumor tissues and achieve effective phototherapy. Combined with chemotherapy, a triple‐modal treatment (PTT, PDT, and chemotherapy) approach is developed to induce the immunogenic cell death of tumor cells and to accelerate the release of damage‐associated molecular patterns. In vivo results suggest that DIMs can promote the maturation of dendritic cells and surge the number of infiltrated immune cells. Meanwhile, DIMs can polarize macrophages from M2 to M1 phenotypes and reduce the percentages of immunosuppressive Tregs, which reverse the immunosuppressive tumor microenvironment and activate systemic antitumor immunity. By achieving synergistic effects on the tumor inhibition and the antitumor immunity activation, DIMs show great promise as new nanoplatforms to treat metastatic breast cancer.

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Light/gas cascade-propelled Janus micromotors that actively overcome sequential and multi-staged biological barriers for precise drug delivery

Cited by 45 publications

References 38 publications

A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules

A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules

“Motile-targeting” drug delivery platforms based on micro/nanorobots for tumor therapy

Near‐Infrared‐Enpowered Nanomotor‐Mediated Targeted Chemotherapy and Mitochondrial Phototherapy to Boost Systematic Antitumor Immunity

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