Light-Enhanced Bacterial Killing and Less Toxic Cell Imaging: Multicationic Aggregation-Induced Emission Matters

Ma, Hengchang; Ma, Yucheng; Lei, Lei; Yin, Wen; Yuan, Ye; Wang, Tao; Yin, Ping; Lei, Ziqiang; Yang, Manyi; Qin, Yuling; Zhang, Shaoxiong

doi:10.1021/acssuschemeng.8b03540

Cited by 26 publications

(24 citation statements)

References 50 publications

(89 reference statements)

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“…In this respect, alternate nontoxic fluorescent materials with other required properties are desired. 237 − 244 AIEgens offer unique optical properties with less toxicity, allowing them to be used as promising fluorescent probes for a highly sensitive and selective detection of pathogens and turn-on fluorescent sensing and imaging. Also, in their aggregate form, AIE-based supramolecular nanostructure forms are proven to be efficient for a light-up diagnosis of a pathogen as well as an image-guided photodynamic inactivation (PDI) therapy for a pathogenic infection.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Saraf

Yaraki

Prateek

et al. 2021

ACS Appl. Nano Mater.

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The COVID-19 outbreak has exposed the world’s preparation to fight against unknown/unexplored infectious and life-threatening pathogens. The unavailability of vaccines, slow or sometimes unreliable real-time virus/bacteria detection techniques, insufficient personal protective equipment (PPE), and a shortage of ventilators and many other transportation equipments have further raised serious concerns. Material research has been playing a pivotal role in developing antimicrobial agents for water treatment and photodynamic therapy, fast and ultrasensitive biosensors for virus/biomarkers detection, as well as for relevant biomedical and environmental applications. It has been noticed that these research efforts nowadays primarily focus on the nanomaterials-based platforms owing to their simplicity, reliability, and feasibility. In particular, nanostructured fluorescent materials have shown key potential due to their fascinating optical and unique properties at the nanoscale to combat against a COVID-19 kind of pandemic. Keeping these points in mind, this review attempts to give a perspective on the four key fluorescent materials of different families, including carbon dots, metal nanoclusters, aggregation-induced-emission luminogens, and MXenes, which possess great potential for the development of ultrasensitive biosensors and infective antimicrobial agents to fight against various infections/diseases. Particular emphasis has been given to the biomedical and environmental applications that are linked directly or indirectly to the efforts in combating COVID-19 pandemics. This review also aims to raise the awareness of researchers and scientists across the world to utilize such powerful materials in tackling similar pandemics in future.

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Section: Biomedical Applicationsmentioning

confidence: 99%

“…However, a lot of improvements are still required for their successful implications in real-world systems. 240 , 241 , 244 , 256 …”

Section: Biomedical Applicationsmentioning

confidence: 99%

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Saraf

Yaraki

Prateek

et al. 2021

ACS Appl. Nano Mater.

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“…To introduce extra PDI effect to the AIE featured polymeric antimicrobial material, Zhang's group synthesized a multiple-cation charged AIE-active polymer, DBPE-DBO105. It exhibited enhanced quantum yield and red-shifted emission wavelength comparing to the DBPE precursor.…”

Section: Bacterial Detection and Killingmentioning

confidence: 99%

AIE-based theranostic systems for detection and killing of pathogens

He¹,

Xiong²,

Zhao³

et al. 2019

Theranostics

125

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Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid and sensitive approaches have been developed for identification and quantification of specific pathogens, but many challenges still exist. Culture/colony counting and polymerase chain reaction are the classical methods used for pathogen detection, but their operations are time-consuming and laborious. On the other hand, the emergence and rapid spread of multidrug-resistant pathogens is another global threat. It is thus of utmost urgency to develop new therapeutic agents or strategies. Luminogens with aggregation-induced emission (AIEgens) and their derived supramolecular systems with unique optical properties have been developed as fluorescent probes for turn-on sensing of pathogens with high sensitivity and specificity. In addition, AIE-based supramolecular nanostructures exhibit excellent photodynamic inactivation (PDI) activity in aggregate, offering great potential for not only light-up diagnosis of pathogen, but also image-guided PDI therapy for pathogenic infection.

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“…So, the fluorescence emission turned‐off due to destruction of the AIE effect which could act as the fluorometric sensing module. Ma's group designed another polymeric antibacterial material based on the multiple‐cation charged AIE‐active polymer, 1,2‐diphenyl‐1,2‐bis(4‐(pyridin‐4‐yl)phenyl) ethane‐1,8‐dibromooctane (DBPE‐DBO), for bacterial imaging, its detection and elimination as well . DBPE‐DBO possessed multiple interactions with bacteria.…”

Section: Aie Active Polymer For Dectection and Elimination Of Bacteriamentioning

confidence: 99%

AIEgen‐Based Fluorescent Nanomaterials for Bacterial Detection and its Inhibition

et al. 2020

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The infections caused by bacteria have affected human health severely. The bacterial infections spread either directly or indirectly by coming in contact with the food during packaging or by the use of medical devices. The efficient theranostic systems for bacteria provide therapeutic effects that have received attentions in the research field. In this prospect, the fluorescent materials have gained tremendous recognition in the biological applications due to their excellent species diversity, optical properties and high sensitivity. However, most of the conventional fluorophores suffer aggregation‐caused quenching (ACQ) effects in the aggregated state. The opposite of ACQ is Aggregation Induced Emission (AIE), where AIEgens play an important role in the imaging, detecting and killing the bacteria as well. In this context, we have summarized the applications of AIEgens on multiple bacterial imaging, detection, discrimination and antibacterial activity to understand the modern theranostic system.

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Light-Enhanced Bacterial Killing and Less Toxic Cell Imaging: Multicationic Aggregation-Induced Emission Matters

Cited by 26 publications

References 50 publications

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

AIE-based theranostic systems for detection and killing of pathogens

AIEgen‐Based Fluorescent Nanomaterials for Bacterial Detection and its Inhibition

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