AIEgen‐Based Fluorescent Nanomaterials for Bacterial Detection and its Inhibition

Roy, Ekta; Nagar, Achala; Chaudhary, Sandeep; Pal, Souvik

doi:10.1002/slct.201904092

Cited by 17 publications

(15 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, researchers have used the peptide with good biocompatibility and biodegradability to combine with AIEgens. 72,73 Bacterial infection can cause many serious inflammatory diseases, such as hepatosplenomegaly, skin rash, septic shock, joint swelling, 74 etc. The current clinical methods are still based on biopsy and specimen analysis.…”

Section: Peptide-based Nanomaterials Integrated In Bacterial Infection Theranosticsmentioning

confidence: 99%

Peptide-Based AIEgens: From Molecular Design, Stimuli Responsiveness to Biomedical Application

et al. 2022

View full text Add to dashboard Cite

Luminogens with Aggregation-Induced Emission (AIEgens) have a wide range of biomedical applications in bioimaging, anti-cancer, antibacterial and other fields owing to its unique photophysical properties. The precise structural design and modification of AIE molecule have aroused great interest in the past years. As a peptides-AIE molecules hybrid material, peptide-based AIEgens generally have better solubility, biocompatibility and lower systemic toxicity. The functional diversity, modularity and portability of peptides provide more possibilities for intelligent structure and functional design of AIEgens. This review summarizes the recent research progress of peptide-based AIEgens nanomaterials, from molecular design, stimuli responsiveness to biomedical application, focusing on the advantages of peptides and AIE molecules conjugates. Finally, a summary of the challenges and opportunities of peptide-based AIEgens nanomaterials for future clinical biomedical applications is given.

show abstract

Section: Peptide-based Nanomaterials Integrated In Bacterial Infection Theranosticsmentioning

confidence: 99%

Peptide-Based AIEgens: From Molecular Design, Stimuli Responsiveness to Biomedical Application

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[79,80] With the predominant capability of versatile functional groups, positive/negatively charged AIE molecules have demonstrated as excellent probes for bacteria detection. [80,81] For instance, Jiang et al [82] reported a fluorescent array composed of five different AIE molecules with various electrostatic properties (Figure 7A). These designed AIE molecules were synthesized with one or two positively/ negatively charged groups.…”

Section: Aggregation Induced Emission (Aie) Materialsmentioning

confidence: 99%

Array‐Based Biosensors for Bacteria Detection: From the Perspective of Recognition

Xianyu

2021

Small

View full text Add to dashboard Cite

Array‐based biosensors have shown as effective and powerful tools to distinguish intricate mixtures with infinitesimal differences among analytes such as nucleic acids, proteins, microorganisms, and other biomolecules. In array‐based bacterial sensing, the recognition of bacteria is the initial step that can crucially influence the analytical performance of a biosensor array. Bacteria recognition as well as the signal readout and mathematical analysis are indispensable to ensure the discrimination ability of array‐based biosensors. Strategies for bacteria recognition mainly include the specific interaction between biomolecules and the corresponding receptors on bacteria, the noncovalent interaction between materials and bacteria, and the specific targeting of bacterial metabolites. In this review, recent advances in array‐based bacteria sensors are discussed from the perspective of bacteria recognition relying on the characteristics of different bacteria. Principles of bacteria recognition and signal readout for bacteria detection are highlighted as well as the discussion on future trends in array‐based biosensors.

show abstract

“…By contrast, aggregation-induced emission PSs (AIE-PSs) emit weak light in molecular species, but shine up upon aggregation due to the restriction of intramolecular motions which suppresses nonradiative decay and results in high ROS generation [11,12,[15][16][17]. Since the first discovery of AIE phenomenon in 2001 [18], AIE-PSs have been successfully applied in the cell [12,[19][20][21][22][23][24][25][26] and bacteria imaging and ablation [4, [27][28][29][30][31][32][33][34][35][36][37][38]. In addition to the membrane-anchoring AIE-PS reported in 2019 that killed 99.9% (3.0 log 10 ) of Staphylococcus aureus (S. aureus) at a concentration of 2 µmol L −1 and 99.9% of E. coli at 5 µmol L −1 [39], most reported antibacterial rates of AIE-PSs did not exceed 99% (2.0 log 10 ).…”

Section: Introductionmentioning

confidence: 99%

A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy

et al. 2021

View full text Add to dashboard Cite

Photodynamic therapy (PDT) has been drawing more and more attention in the antibacterial field. Traditional photosensitizers (PSs) tend to aggregate in aqueous media, which reduces the generation of reactive oxygen species (ROS) and seriously affects the photodynamic efficacy. Many efforts have been made to prevent aggregation of traditional PSs. By contrast, aggregation-induced emission PSs (AIE-PSs) take advantage of aggregation to boost ROS generation and fluorescence intensity. However, the efficacies of the reported antibacterial AIE-PSs are poor. Herein, we report a new class of highly effective antibacterial AIE-PSs based on nitrobenzoic acid structure. TTVBA, a negatively charged AIE-PS, can not only selectively kill spherical bacteria (Staphylococcus aureus (S. aureus)) rather than rod-shaped bacteria (Escherichia coli (E. coli)), but also be easily extended to several AIE-PSs (TTVBP1-3) with positive charges and broad-spectrum antibacterial activity. We demonstrate that TTVBP2 can kill 3.0 log 10 of S. aureus at very low concentration (125 nmol L −1 ), TTVBP3 can kill 4.7 log 10 of Staphylococcus epidermidis (S. epidermidis) at a concentration of 1 µmol L −1 and 3.8 log 10 of E. coli at 5 µmol L −1 , thus enabling them among the most effective antibacterial AIE-PSs reported so far. Meanwhile, these AIE-PSs exhibit excellent wash-free imaging ability for bacteria by simple mixing with bacteria. We thus envision that TTVBA, a nitrobenzoic acid-based extendable AIE-PS, provides a new route for the design of AIE-PSs in antibacterial treatment.

show abstract

AIEgen‐Based Fluorescent Nanomaterials for Bacterial Detection and its Inhibition

Cited by 17 publications

References 100 publications

Peptide-Based AIEgens: From Molecular Design, Stimuli Responsiveness to Biomedical Application

Peptide-Based AIEgens: From Molecular Design, Stimuli Responsiveness to Biomedical Application

Array‐Based Biosensors for Bacteria Detection: From the Perspective of Recognition

A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy

Contact Info

Product

Resources

About