Luminogens with Aggregation-Induced Emission (AIEgens) have a wide range of biomedical applications in bioimaging, anti-cancer, antibacterial and other fields owing to its unique photophysical properties. The precise structural design and modification of AIE molecule have aroused great interest in the past years. As a peptides-AIE molecules hybrid material, peptide-based AIEgens generally have better solubility, biocompatibility and lower systemic toxicity. The functional diversity, modularity and portability of peptides provide more possibilities for intelligent structure and functional design of AIEgens. This review summarizes the recent research progress of peptide-based AIEgens nanomaterials, from molecular design, stimuli responsiveness to biomedical application, focusing on the advantages of peptides and AIE molecules conjugates. Finally, a summary of the challenges and opportunities of peptide-based AIEgens nanomaterials for future clinical biomedical applications is given.
Therapeutic peptides have been widely concerned, but their efficacy is limited by the inability to penetrate cell membranes, which is a key bottleneck in peptide drugs delivery. Herein, an in vivo self‐assembly strategy is developed to induce phase separation of cell membrane that improves the peptide drugs internalization. A phosphopeptide KYp is synthesized, containing an anticancer peptide [KLAKLAK]2 (K) and a responsive moiety phosphorylated Y (Yp). After interacting with alkaline phosphatase (ALP), KYp can be dephosphorylated and self‐assembles in situ, which induces the aggregation of ALP and the protein‐lipid phase separation on cell membrane. Consequently, KYp internalization is 2‐fold enhanced compared to non‐responsive peptide, and IC50 value of KYp is approximately 5 times lower than that of free peptide. Therefore, the in vivo self‐assembly induced phase separation on cell membrane promises a new strategy to improve the drug delivery efficacy in cancer therapy.
Immunogenic cell death (ICD), as an unusual cell death pattern, mediates cancer cells to release a series of damage-associated molecular patterns (DAMPs), which is widely used in the field of...
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