Light- and pH-activated intracellular drug release from polymeric mesoporous silica nanoparticles

Tian, Ye; Kong, Yi; Li, Xiaojian; Wu, Jun; Ko, Alex C.‐T.; Xing, Malcolm

doi:10.1016/j.colsurfb.2015.04.069

Cited by 26 publications

(10 citation statements)

References 65 publications

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“…Hence our particles will be much more compatible for body as they are almost non-toxic upto very high dose. Hence these results indicate that our particles qualitatively better in respect of other results3637.…”

Section: Resultssupporting

confidence: 69%

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Goswami

2016

Sci Rep

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This paper reports on synthesis of hollow spheres of magnetite, guided by micelles and their application in drug release by the stimulus responsive technique. Here oleyelamine micelles are used as the core substance for the formation of magnetite nano hollow spheres (NHS). Diameter and shell thickness of NHS have been changed by changing concentration of the micelles. Mechanism of NHS formation has been established by investigating the aliquot collected at different time during the synthesis of NHS. It has been observed that oleyelamine as micelles play an important role to generate hollow-sphere particles of different diameter and thickness just by varying its amount. Structural analysis was done by XRD measurement and morphological measurements, SEM and TEM were performed to confirm the shape and size of the NHS. FTIR measurement support the formation of magnetite phase too. Frequency dependent AC magnetic measurements and AC magnetic field stimulated drug release event by these particles provide a direction of the promising application of these NHS for better cancer treatment in near future. Being hollow & porous in structure and magnetic in nature, such materials will also be useful in other applications such as in removal of toxic materials, magnetic separation etc.

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Section: Resultssupporting

confidence: 69%

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Goswami

2016

Sci Rep

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“…However, acrylates and methacrylates can be used as part of the backbone of amine-based monomers that can lead to polymers capable of suffering a hydrophobic to hydrophilic phase transition when the pH drops below physiological pH due to the protonation of its tertiary amine groups. Poly(2-(dimethylamino)ethyl acrylate) (PDMAEA) has been used as a pH-responsive gatekeeper alone [ 184 ] or combined with light-responsive moieties [ 185 ]. Recently, poly(2-(pentamethyleneimino)ethyl methacrylate) (PPEMA) has been proposed as a pH-sensitive gate [ 186 ], although the most used amine-based methacrylate is poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA).…”

Section: Supramolecular Structures As Pore-capping Agentsmentioning

confidence: 99%

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017

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The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents.

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“…The most common approaches for light controlled release utilize molecules that undergo lightcontrolled isomerization, photo-polymerization and photo-cleavage [7,8]. Thus, azobenzene cistrans isomerization can trigger release from liposomes [9] polymer vesicles and micelles [10,11] and inorganic porous nanomaterials [12,13]. Photo cleavage reactions in o-nitrobenzyl [14][15][16], coumarin [17], spiropyran [18,19], malachite green [20], cynnamic acid [21,22] derivatives, etc can produce photo-driven hydrophobicity and charge changes, polymer/lipid fragmentation and de-crosslinking.…”

Section: Introductionmentioning

confidence: 99%

Light-triggered release from dye-loaded fluorescent lipid nanocarriers in vitro and in vivo

Bouchaala

Anton

et al. 2017

Colloids and Surfaces B: Biointerfaces

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Light is an attractive trigger for release of active molecules from nanocarriers in biological systems. Here, we describe a phenomenon of light-induced release of a fluorescent dye from lipid nano-droplets under visible light conditions. Using auto-emulsification process we prepared nanoemulsion droplets of 32nm size encapsulating the hydrophobic analogue of Nile Red, NR668. While these nano-droplets cannot spontaneously enter the cells on the time scale of hours, after illumination for 30s under the microscope at the wavelength of NR668 absorption (535nm), the dye showed fast accumulation inside the cells. The same phenomenon was observed in zebrafish, where nano-droplets initially staining the blood circulation were released into endothelial cells and tissues after illumination. Fluorescence correlation spectroscopy revealed that laser illumination at relatively low power (60mW/cm) could trigger the release of the dye into recipient media, such as 10% serum or blank lipid nanocarriers. The photo-release can be inhibited by deoxygenation with sodium sulfite, suggesting that at least in part the release could be related to a photochemical process involving oxygen, though a photo-thermal effect could also take place. Finally, we showed that illumination of NR668 can provoke the release into the cells of another highly hydrophobic dye co-encapsulated into the lipid nanocarriers. These results suggest dye-loaded lipid nano-droplets as a prospective platform for preparation of light-triggered nanocarriers of active molecules.

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Light- and pH-activated intracellular drug release from polymeric mesoporous silica nanoparticles

Cited by 26 publications

References 65 publications

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

Synthesis of Micelles Guided Magnetite (Fe3O4) Hollow Spheres and their application for AC Magnetic Field Responsive Drug Release

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Light-triggered release from dye-loaded fluorescent lipid nanocarriers in vitro and in vivo

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