Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices

Miyamoto, Ko Ichiro; Sato, Taketomo; Abe, Mamoru; Wagner, Torsten; Schöning, Michael J.; Yoshinobu, Tatsuo

doi:10.3390/mi7070111

Cited by 17 publications

(16 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the accurate quantification of the pH is an important feature to be considered for long‐term monitoring of the 3D biomodels. Typically, the pH monitoring is made through light‐addressable potentiometric sensors (LAPS), [ 134 ] ion‐selective field effect transistors (ISFET), [ 135 ] metal oxide‐based potentiometric sensors, [ 136 ] or optical pH sensors. [ 137 ] Among these strategies, Zhang and co‐workers have developed an optical pH sensor based in the absorption of phenol red (≈515 nm, a supplement of culture medium that indicates the pH value), in the pH range of 6.5–8.0 with linear response and sensitivity of 0.159 V pH −1 .…”

Section: The Importance Of Sensors In Ooc Platformsmentioning

confidence: 99%

Organ‐on‐a‐Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine

Rodrigues

Sousa

Gaspar

et al. 2020

Small

View full text Add to dashboard Cite

Nanomedicine has emerged in the last few decades as a field that can significantly impact the diagnose and therapy of human diseases. [1,2] Based on the outstanding properties that materials acquired at the nanoscale, such as high surface-to-volume ratio, high physicochemical stability, high charge carrier mobility and biocompatibility, a variety of nanoformulations have been developed to be applied in medicine by tailoring their size, shape, charge, and surface functional groups. [2,3] Based on those properties, the design of multifunctional nanoparticles (NPs) for nanomedicine is one of the most promising and exciting research areas that is expected to revolutionize the medical field in the next few decades. [4] Some of these multifunctional NPs have the potentiality to combine both diagnosis and therapy, the so-called theranostics, which is one of the ultimate goals of this field to achieve personalized and precise medical care (Figure 1). Among the therapeutic techniques, nanomaterials developed for drug delivery purpose have been widely investigated as smart drug nanocarriers capable to target tumor cells, protect drugs from degradation, enhance drug solubility, improve biodistribution, extend drug life cycle, and prevent lethal side-effects to healthy tissues and organs. [2,3] The design of these smart drug delivery systems can be engineered to target a specific location by taking advantages of the host environment, using for instance antibodies, aptamers or peptides; and then react autonomously as stimuli-responsive drug release agents, triggered by endogeneous chemical reactions (e.g., enzymes, pH, hydrolysis) or exogeneous stimulisensitive mechanisms (e.g., near infrared light, temperature raise induced by an alternating magnetic field, among others). [5] Comprehensive reviews on the topic of smart nano-based drug delivery systems can be found elsewhere. [5,6] Further complex functionality is represented by smart theranostics, which hold high promise for the nanomedicine of the future. Next, recent representative examples from the research arena are described. Cai et al. [7] make use of enzyme-responsiveness to design a cathepsin B-sensitive theranostic agent. They synthesized a biodegradable conjugate composed of a Gd chelate (Gd-DOTA) as a T1-magnetic resonance imaging (MRI) contrast agent, Despite the progress achieved in nanomedicine during the last decade, the translation of new nanotechnology-based therapeutic systems into clinical applications has been slow, especially due to the lack of robust preclinical tissue culture platforms able to mimic the in vivo conditions found in the human body and to predict the performance and biotoxicity of the developed nanomaterials. Organ-on-a-chip (OoC) platforms are novel microfluidic tools that mimic complex human organ functions at the microscale level. These integrated microfluidic networks, with 3D tissue engineered models, have been shown high potential to reduce the discrepancies between the results derived from preclinical and clinical trials. However, ...

show abstract

Section: The Importance Of Sensors In Ooc Platformsmentioning

confidence: 99%

Organ‐on‐a‐Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine

Rodrigues

Sousa

Gaspar

et al. 2020

Small

View full text Add to dashboard Cite

show abstract

“…The commonly used materials for the sensor chip (silicon oxynitride) and microfluidic channel devices (polydimethylsiloxane (PDMS)) can be easily bonded together by plasma treatment. Secondly, due to the addressability of LAPS, any position within the microfluidic channel is measurable [138], which contributes to the assays based on chemical imaging. Thirdly, thanks to the good breathability, biocompatibility and light transmission of PDMS materials, LAPS integrated with microfluidics can be used for biomedical measurements [139] and optical images can also be obtained under a microscope.…”

Section: Integration With Microfluidic Devicesmentioning

confidence: 99%

“…LAPS-based chemical imaging sensor can simultaneously analyze the chemical reaction and diffusion of the analyte in a microfluidic channel. Miyamoto et al [138] proposed a plug-based microfluidic system combined with LAPS. The structure of the integrated system is shown in Figure 8a.…”

Section: Integration With Microfluidic Devicesmentioning

confidence: 99%

See 1 more Smart Citation

Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs)

Liang

Qiu

Gan

et al. 2019

Sensors

View full text Add to dashboard Cite

A light-addressable potentiometric sensor (LAPS) is a semiconductor electrochemical sensor based on the field-effect which detects the variation of the Nernst potential on the sensor surface, and the measurement area is defined by illumination. Thanks to its light-addressability feature, an LAPS-based chemical imaging sensor system can be developed, which can visualize the two-dimensional distribution of chemical species on the sensor surface. This sensor system has been used for the analysis of reactions and diffusions in various biochemical samples. In this review, the LAPS system set-up, including the sensor construction, sensing and substrate materials, modulated light and various measurement modes of the sensor systems are described. The recently developed technologies and the affecting factors, especially regarding the spatial resolution and temporal resolution are discussed and summarized, and the advantages and limitations of these technologies are illustrated. Finally, the further applications of LAPS-based chemical imaging sensors are discussed, where the combination with microfluidic devices is promising.

show abstract

“…They also discuss several alternative strategies, aimed at eliminating the reference electrode altogether, in particular, two-electrode electrochemical cells, bipolar electrodes, and chronopotentiometry. Miyamoto et al [ 2 ] propose a plug-based microfluidic system, based on the principle of the light-addressable potentiometric sensor (LAPS). LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on a sensing surface.…”

mentioning

confidence: 99%

Micro/Nano Devices for Chemical Analysis

Tokeshi

Sato

2016

Micromachines

View full text Add to dashboard Cite

show abstract

Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices

Cited by 17 publications

References 11 publications

Organ‐on‐a‐Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine

Organ‐on‐a‐Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine

Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs)

Micro/Nano Devices for Chemical Analysis

Contact Info

Product

Resources

About