Ligation of patent ductus arteriosus in very low birth weight premature infants

Othman, Hasan F.; Linfield, Debra T.; Mohamed, Mohamed A.; Aly, Hany

doi:10.1016/j.pedneo.2020.03.009

Cited by 12 publications

(14 citation statements)

References 20 publications

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“…From National Health Insurance data in Korea, the prevalence of PDA in VLBW infants was 45%, while the prevalence of PDA ligation in VLBW infants was 22%, which was comparable to population studies from the US and Canada 4 , 21 , 22 . From the healthcare insurance dataset of 429,900 VLBW infants in the US from 1998 to 2015, 35% of infants were diagnosed with PDA and 18% had undergone PDA ligation 22 . From the Canadian Neonatal Network (CNN) database in infants under 32 weeks of gestation, 3,673 infants (25%) were diagnosed with PDA and 26.4% of those infants had undergone PDA ligation in 2012 4 .…”

Section: Discussionsupporting

confidence: 67%

Patent ductus arteriosus treatment trends and associated morbidities in neonates

Park

Yoon

Han

et al. 2021

Sci Rep

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To evaluate national epidemiologic data on infants treated for patent ductus arteriosus (PDA) in Korea and analyze outcomes associated with different PDA treatments. We retrospectively evaluated data on 12,336 patients diagnosed with PDA (International Classification of Diseases-10 code: Q250) between 2015 and 2018 from the Health Insurance Review and Assessment database. Among them, 1623 patients underwent surgical ligation (code: O1671). We used birth certificate data from Statistics Korea to estimate the prevalence, diagnosis, and treatment of PDA. The prevalence of infants with PDA was 81 infants per 10,000 live births and 45.2% in very low birth weight (VLBW) infants, which increased from 2015 to 2018. PDA ligation was performed in 2571 infants and 22% VLBW infants. Medical treatment was administered to 4202 infants, which decreased significantly, especially in VLBW infants (62% to 53%). The proportion of treatment was as follows: conservative treatment (53.1%), intravenous ibuprofen (24.4%), surgery (20.4%), and oral ibuprofen (10.7%); that among 4854 VLBW infants was as follows: intravenous ibuprofen (46.3%), conservative treatment (33.2%), surgery (22.2%), and oral ibuprofen (14.2%). Surgical treatment had a significantly higher risk (odds ratio 1.36) of mortality than conservative treatment. Surgical and/or medical treatments were associated with a higher risk of morbidity. Recently, increased use of conservative management of PDA has contributed to improved neonatal outcomes in VLBW infants. Select patients may still benefit from surgical ligation following careful consideration.

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Section: Discussionsupporting

confidence: 67%

Patent ductus arteriosus treatment trends and associated morbidities in neonates

Park

Yoon

Han

et al. 2021

Sci Rep

View full text Add to dashboard Cite

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“…25 In US, PDA ligation still remained around 12.7% in 2015. 22 From the CNN, 26.4% of the infants with a PDA diagnosis underwent PDA ligation in 2012. 4 From the cohort in California, infants undergoing primary ligation slightly increased from 2008 to 2014.…”

Section: Discussionmentioning

confidence: 99%

“…From National Health Insurance data in Korea, the incidence of PDA in VLBW infants was 45%, while the incidence of PDA ligation in VLBW infants was 22%, which was comparable to population studies from the US and Canada. 4,21,22 From the healthcare insurance dataset of 429,900 VLBW infants in the US from 1998 to 2015, 35% of infants were diagnosed with PDA and 18% had undergone PDA ligation. 22 From the Canadian Neonatal Network (CNN) database in infants under 32 weeks of gestation, 3,673 infants (25%)…”

Section: Discussionmentioning

confidence: 99%

“…4,21,22 From the healthcare insurance dataset of 429,900 VLBW infants in the US from 1998 to 2015, 35% of infants were diagnosed with PDA and 18% had undergone PDA ligation. 22 From the Canadian Neonatal Network (CNN) database in infants under 32 weeks of gestation, 3,673 infants (25%)…”

Section: Discussionmentioning

confidence: 99%

“…13,14,15,16,17,18 In US, PDA ligation peaked at 23.7% in 2004 and decreased to 12.7% in 2015. 22 From the retrospective cohort study of VLBW infants in California, between 2008 and 2014, the annual rate of infants undergoing pharmacologic intervention (31% vs 16%) decreased, whereas the proportion of infants who were not treated (61% vs 78%) increased. This tendency was also found in the current study.…”

Section: Discussionmentioning

confidence: 99%

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Patent Ductus Arteriosus Treatment Trends and Associated Morbidities in Neonates

Park

Song

Lim

et al. 2021

Preprint

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Objectives: To evaluate national epidemiologic data on infants treated for patent ductus arteriosus (PDA) in Korea and analyze outcomes associated with different PDA treatments. Study Design: We retrospectively evaluated data on 12,336 patients diagnosed with PDA (International Classification of Diseases-10 code: Q250) between 2015 and 2018 from the Health Insurance Review and Assessment database. Among them, 1,623 patients underwent surgical ligation (code: O1671). We used birth certificate data from Statistics Korea to estimate the prevalence, diagnosis, and treatment of PDA. Results: The prevalence of infants with PDA was 81 infants per 10,000 live births and 45.2% in very low birth weight (VLBW) infants, which increased from 2015 to 2018. PDA ligation was performed in 2571 infants and 22% VLBW infants. Medical treatment was administered to 4202 infants, which decreased significantly, especially in VLBW infants (62% to 53%). The proportion of treatment was as follows: conservative treatment (53.1%), intravenous ibuprofen (24.4%), surgery (20.4%), and oral ibuprofen (10.7%); that among 4,854 VLBW infants was as follows: intravenous ibuprofen (46.3%), conservative treatment (33.2%), surgery (22.2%), and oral ibuprofen (14.2%). Surgical treatment had a significantly higher risk (odds ratio 1.36) of mortality than conservative treatment. Surgical and/or medical treatments were associated with a higher risk of morbidity.Conclusion: Recently, increased use of conservative management of PDA has contributed to improved neonatal outcomes in VLBW infants. Select patients may still benefit from surgical ligation following careful consideration.

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Lung ultrasound score predicts patent ductus arteriosus ligation among neonates ≤25 weeks

Zong

Huang

et al. 2023

Pediatric Pulmonology

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BackgroundThis prospective study aimed to investigate whether lung ultrasound score (LUSs) can predict the patent ductus arteriosus (PDA) ligation.MethodsPreterm infants ≤25 weeks of gestational age (GA) were enrolled. A lung ultrasound was performed on the 14th day of life. Each lung zone was given a score between 0 and 4. A receiver‐operating characteristic (ROC) curve was constructed to evaluate the ability of the LUSs for predicting ligation.ResultsA total of 81 infants were eligible with a median GA and birth weight (BW) of 25 weeks (24.1–25.2) and 710 g (645–770), respectively. The median time from birth to ligation was 35 days (32–51). Those who underwent ligation had a longer time of mechanical ventilation (34 [26–39] vs. 19 [12–30], p < 0.001), shorter time of noninvasive respiratory support (39 [32–51] vs. 50 [41.5–57], p < 0.01), higher incidence of the bronchopulmonary dysplasia (BPD) (p < 0.01), and severe BPD (p < 0.001). The LUSs had an area under the ROC of 0.96 (95% confidence interval: 0.93–0.99) for the prediction of ligation. A LUSs cutoff of 36 has a sensitivity and specificity of 96% and 86% and positive and negative predictive values of 82% and 98%, respectively.ConclusionsLUSs at an early stage of life can predict PDA ligation in extremely preterm infants. It would be helpful to reduce morbidity by reducing the duration and magnitude of respiratory support.

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Ligation of patent ductus arteriosus in very low birth weight premature infants

Cited by 12 publications

References 20 publications

Patent ductus arteriosus treatment trends and associated morbidities in neonates

Patent ductus arteriosus treatment trends and associated morbidities in neonates

Patent Ductus Arteriosus Treatment Trends and Associated Morbidities in Neonates

Lung ultrasound score predicts patent ductus arteriosus ligation among neonates ≤25 weeks

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