Ligand exchange triggered controlled-release targeted drug delivery system based on core–shell superparamagnetic mesoporous microspheres capped with nanoparticles

Teng, Zhaogang; Zhu, Xingang; Zheng, Gengfeng; Zhang, Fan; Deng, Yonghui; Xiu, Lichen; Li, Wei; Yang, Qing; Zhao, Dongyuan

doi:10.1039/c2jm32331a

Cited by 31 publications

(17 citation statements)

References 54 publications

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“…Moreover, due to their unique perpendicular orientation, the mesopore channels of the microspheres are readily accessible, favoring the adsorption and release of large species triggered by external stimulus. Afterwards, this versatile method has attracted explosive attention worldwide for the synthesis of multifunctional ordered mesoporous SiO 2 core‐shell nanostructures, such as Fe 2 O 3 @SiO 2 @mSiO 2 ,117, 118 Ag@SiO 2 @mSiO 2 ,119 ZSM‐5@mSiO 2 120 and doped‐NaYF 4 @SiO 2 @mSiO 2 121, 122. Besides the silica layer, negatively charged molecules (e.g., citric acid, polyacrylic acid, rich‐oxygen functional groups) on the surface of the core can also promote the interfacial assembly of mesoporous silica 123–125…”

Section: Liquid‐solid Interfacial Assemblymentioning

confidence: 99%

Ordered Mesoporous Materials Based on Interfacial Assembly and Engineering

et al. 2013

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Ordered mesoporous materials have inspired prominent research interest due to their unique properties and functionalities and potential applications in adsorption, separation, catalysis, sensors, drug delivery, energy conversion and storage, and so on. Thanks to continuous efforts over the past two decades, great achievements have been made in the synthesis and structural characterization of mesoporous materials. In this review, we summarize recent progresses in preparing ordered mesoporous materials from the viewpoint of interfacial assembly and engineering. Five interfacial assembly and synthesis are comprehensively highlighted, including liquid-solid interfacial assembly, gas-liquid interfacial assembly, liquid-liquid interfacial assembly, gas-solid interfacial synthesis, and solid-solid interfacial synthesis, basics about their synthesis pathways, princples and interface engineering strategies.

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Section: Liquid‐solid Interfacial Assemblymentioning

confidence: 99%

Ordered Mesoporous Materials Based on Interfacial Assembly and Engineering

et al. 2013

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“…Current carrier systems that are loaded with multiple therapeutics in a single isotropic particle lack this characteristic and may even promote antagonistic cross-interactions between drugs [9,20–22]. Thus far, several approaches have been developed to fabricate carrier systems that can selectively encapsulate therapeutics in unique environments (composed of different materials) such as capsules [18], LbL (Layer-by-Layer) particles [23,24], templated particles [25,26], core-shell structures [27,28], and dendrimers [29,30]. While these strategies have allowed for the spatioselective encapsulation of therapeutics, few have led to distinct release profiles of two drugs from the same particle [31].…”

Section: Introductionmentioning

confidence: 99%

Multimodal delivery of irinotecan from microparticles with two distinct compartments

Rahmani

Park

Dishman

et al. 2013

Journal of Controlled Release

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In the last several decades, research in the field of drug delivery has been challenged with the fabrication of carrier systems engineered to deliver therapeutics to the target site with sustained and controlled release kinetics. Herein, we report the fabrication of microparticles composed of two distinct compartments: i) one compartment containing a pH responsive polymer, acetal-modified dextran, and PLGA (polylactide-co-glycolide), and ii) one compartment composed entirely of PLGA. We demonstrate the complete release of dextran from the microparticles during a 10-hour period in an acidic pH environment and the complete degradation of one compartment in less than 24 h. This is in congruence with the stability of the same microparticles in neutral pH over the 24-hour period. Such microparticles can be used as pH responsive carrier systems for drug delivery applications where their cargo will only be released when the optimum pH window is reached. The feasibility of the microparticle system for such an application was confirmed by encapsulating a cancer therapeutic, irinotecan, in the compartment containing the acetal-modified dextran polymer and the pH dependent release over a 5-day period was studied. It was found that upon pH change to an acidic environment, over 50% of the drug was first released at a rapid rate for 10 h, similar to that observed for the dextran release, before continuing at a more controlled rate for 4 days. As such, these microparticles can play an important role in the fabrication of novel drug delivery systems due to the selective, controlled, and pH responsive release of their encapsulated therapeutics.

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“…MTB DNA detection with SPION is possible because it provides a higher surface area the size of our particles is 9.7 nm. Magnetic particles less than about 30 nm shows superparamagnetism [38,39]. FT-IR spectrum shows the peaks at 1626 cm -1 and 3407 cm -1 can be attributed to the stretching vibration of the hydroxyl groups on the surface of the SPION [40].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

RJLBPCS

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ABSTRACT:A Mycobacterium DNA extraction protocol utilizing SPION developed and compared with the conventional and commercial kit method. The quality, quantity, and feasibility of the recovered DNA from all four different methods towards various molecular techniques were observed. In our work, morphology, bonding and composite of SPION is determined by various characterization techniques such as XRD, FT-IR, VSM, UV-vis spectroscopy and FE-SEM. XRD analysis confirms the crystallite size and phase purity of the synthesized material. The average crystallite size obtained were ~ 9.7 nm for SPION, prepared by a Co-precipitation method. FT-IR spectrum also confirms the formation of SPIONs. UV-vis spectrophotometry and gel electrophoresis analysis resulted in highest MTB DNA yield (985.3 ng/µl) and the purity was measured by the ratio A260 / A280 = 1.89. The comparative study suggested that the protocol developed in this report is a unique cost effective and highly pure. Further, Real-time PCR also confirms the superiority of our technique.

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Ligand exchange triggered controlled-release targeted drug delivery system based on core–shell superparamagnetic mesoporous microspheres capped with nanoparticles

Cited by 31 publications

References 54 publications

Ordered Mesoporous Materials Based on Interfacial Assembly and Engineering

Ordered Mesoporous Materials Based on Interfacial Assembly and Engineering

Multimodal delivery of irinotecan from microparticles with two distinct compartments

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