2015
DOI: 10.1371/journal.pone.0128321
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Ligamentum Flavum Hypertrophy in Asymptomatic and Chronic Low Back Pain Subjects

Abstract: PurposeTo examine ligamentum flavum thickness using magnetic resonance (MR) images to evaluate its association with low back pain symptoms, age, gender, lumbar level, and disc characteristics.Materials and MethodsSixty-three individuals were part of this IRB-approved study: twenty-seven with chronic low back pain, and thirty-six as asymptomatic. All patients underwent MR imaging and computed tomography (CT) of the lumbar spine. The MR images at the mid-disc level were captured and enlarged 800% using a bilinea… Show more

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Cited by 39 publications
(41 citation statements)
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“…In these cases, LF samples from LDH patients, for which the age group is often younger than that of patients with LSS, were used as controls. Several studies have been reported that the thickness of the LF is associated with age [16][17][18][19] . In fact, the area ratio was associated to age (rs=0.548, p=0.012) in the present subjects (n=20), and age-related miRNA expression patterns were also identified in this study.…”
Section: Discussionmentioning
confidence: 99%
“…In these cases, LF samples from LDH patients, for which the age group is often younger than that of patients with LSS, were used as controls. Several studies have been reported that the thickness of the LF is associated with age [16][17][18][19] . In fact, the area ratio was associated to age (rs=0.548, p=0.012) in the present subjects (n=20), and age-related miRNA expression patterns were also identified in this study.…”
Section: Discussionmentioning
confidence: 99%
“…LSS can lead to nerve root compression, low back pain and intermittent claudication and can even develop into paralysis [4][5][6]. Patients with LSS usually suffer from these symptoms for many years, which cause significant morbidity.…”
Section: Discussionmentioning
confidence: 99%
“…LSS can lead to severe low back pain, leg pain, intermittent claudication and disability [4,5]. There are several pathogenic factors that lead to LSS, such as disc degeneration, facet degeneration, and hypertrophy of the ligamentum flavum (HLF) [6].…”
Section: Introductionmentioning
confidence: 99%
“…Transforming growth factor beta is related to the stimulation of fibrosis. The process of LF thickening begins with mechanical stress, which induces inflammation, tissue damage, scarring, and finally, fibrosis (15). Abnormal movement can cause mechanical stress and inflammation, although the pathogenesis of the inflammatory reaction in LF ap-…”
Section: Discussionmentioning
confidence: 99%
“…The Ligamentum Flavum Area as a Morphological Parameter pears to be multifactorial (15,16). Many studies have evaluated the associations between the LFT on MRI and the signs and symptoms of LCSS (4,17).…”
Section: E423mentioning
confidence: 99%