Lifetime Risk of Hip Fractures is Underestimated

Odén, Anders; Dawson, A.; Dere, Willard H.; Johnell, Olof; Jönsson, Bengt; Kanis, John А.

doi:10.1007/s001980050105

Cited by 160 publications

(108 citation statements)

References 12 publications

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“…There are over 1.5 million osteoporotic fractures annually in the United States, with hip fracture remaining a leading cause of morbidity and mortality in the elderly that consumes a disproportionate amount of health care resources, is associated with substantial pain, and significantly decreases active life expectancy [2][3][4]. Alarming are also the predictions of increasing number of fractures and associated health-care burden as the population ages [5].…”

Section: Introductionmentioning

confidence: 99%

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Demissie

Dupuis

Cupples

et al. 2007

Bone

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Section: Introductionmentioning

confidence: 99%

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Demissie

Dupuis

Cupples

et al. 2007

Bone

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“…Hip and vertebral mortality rates in the first and following years after fracture event were derived from different published sources [27,128,130], respectively. In the raloxifene, study a relative risk of mortality after clinical vertebral fractures estimated at 2.5 the year after fracture and 1.3 in subsequent years for all ages was used.…”

Section: Epidemiological Datamentioning

confidence: 99%

Health economics of osteoporosis

Borgström¹,

Kanis²

2008

Best Practice & Research Clinical Endocrinology & Metab

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“…As such, males account for approximately 30% of hip and 20% of symptomatic vertebral fractures (8). Consistent with a major fracture burden among men, it is estimated that a 50-year-old male has a 17% chance of sustaining a hip fracture in his remaining lifetime (9). As such, it is clear that osteoporosis is a major health problem for both women and men.…”

Section: Definition and Epidemiologymentioning

confidence: 99%

Osteoporosis in men

Binkley¹

2006

Arq Bras Endocrinol Metab

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Osteoporosis is defined as "a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture". Approximately 40-50% of women sustain osteoporotic fractures in their lifetime; as such, it is appropriate that studies initially focused upon females. Despite an increased recognition of osteoporotic fractures in men, there continues to be neglect of this disease in males. This ongoing neglect is inappropriate as 25-33% of men in some populations will sustain osteoporotic fractures in their lifetime. Testosterone plays an important role in male skeletal health. However, recent data suggest that estrogen may in fact be the dominant hormone regulating skeletal status in both men and women. BMD measurement may be utilized for osteoporosis diagnosis and to assist with fracture risk prediction in men prior to their sustaining a fracture. Recognizing this need, the International Society for Clinical Densitometry (ISCD) recommended and recently reaffirmed use of a BMD T-score of -2.5 or below be utilized to diagnose osteoporosis in men. Androgen therapy of hypogonadal men may be considered with the caveat that data do not exist to document that this treatment reduces fracture risk. At this time, the data is inadequate to support use of androgen treatment in eugonadal men with osteoporosis. Parathyroid hormone treatment does increase BMD; existing studies have not been of adequate size or duration to document fracture reduction efficacy. Bisphosphonate therapy increases BMD, reduces vertebral fracture risk and is considered the standard of care for osteoporotic men at this point in time. RESUMO Osteoporose em Homens.A osteoporose é definida como "uma doença esquelética sistêmica caracterizada por baixa massa óssea e deterioração da microarquitetura do tecido ósseo com conseqüente aumento da susceptibilidade a fraturas". Aproximadamente 40-50% das mulheres apresentarão uma fratura osteoporótica durante suas vidas, e por isso os estudos iniciais focalizaram o sexo feminino. A despeito do reconhecimento cada vez mais freqüente da ocorrência de fraturas osteoporóticas em homens, a doença continua sendo negligenciada no sexo masculino. Isto não é apropriado na medida em que 25-33% dos homens em algumas populações apresentarão fraturas osteoporóticas durante suas vidas. A testosterona exerce um importante papel na integridade esquelética masculina, contudo dados recentes sugerem que os estrógenos são de fato os hormônios dominantes na regulação esquelética em ambos os sexos. A medida da densidade mineral óssea pode ser utilizada no diagnóstico e para avaliar o risco de fraturas, e a ISCD recomenda que o escore T de -2.5 ou menos seja usado como critério diagnóstico no homem. A terapia androgênica no hipogonadismo masculino deve ser original articleOsteoporosis in Men

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Lifetime Risk of Hip Fractures is Underestimated

Cited by 160 publications

References 12 publications

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Health economics of osteoporosis

Osteoporosis in men

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