Lifetime Probabilities of Hematopoietic Stem Cell Transplantation in the U.S.

Abstract

Healthcare policies regarding hematopoietic stem cell transplantation (HSCT) must address the need for the procedure as well as the availability of stem cell sources: bone marrow, peripheral blood, or umbilical cord blood (UCB). However, data with respect to the lifetime probability of undergoing HSCT are lacking. This study was undertaken to estimate the latter probability in the United States (U.S.), depending on age, sex, and race. We used data from the Center for International Blood and Marrow Transplant Research, the U.S. Surveillance, Epidemiology and End Results Program, and the U.S. Census Bureau and calculated probabilities as cumulative incidences. Several scenarios were considered: assuming current indications for autologous and allogeneic HSCT, assuming universal donor availability, and assuming broadening of HSCT use in hematologic malignancies. Incidences of diseases treated with HSCT and of HSCTs performed increase with age, rising strongly after age 40. Among individuals older than 40, incidences are higher for men than for women. The lifetime probabilities of undergoing HSCT range from 0.23% to 0.98% under the various scenarios. We conclude that, given current indications, the lifetime probability of undergoing autologous or allogeneic HSCT is much higher than previously reported by others and could rise even higher with increases in donor availability and HSCT applicability.

Risk score for outcome after allogeneic hematopoietic stem cell transplantation

“…Today, >30,000 such allogeneic transplants are currently performed worldwide per year. 3 Allogeneic HSCT can provide a cure in otherwise lethal disorders. It gives proof of principle of an immunological control of malignancy by a graft-versus-tumor effect.…”

Awareness of cord blood banking among pregnant women in semi urban area

“…16 Odds of a child using autologous cord blood in US is1: 5,000. 17 A child using donor (allogeneic) cord blood is 1:2,500.…”

The rationale behind collecting umbilical cord blood

“…(39). Considering this perspective it seems that all expectant parents should be advised properly by their doctors with complete and up-todate information, thus helping the parents to make a sound decision regarding whether to store the CB of their baby in a private family bank or to donate it to a public bank.…”