Lifetime prevalence of brief recurrent depression (results from a community survey)

Altamura, A.C.; Carta, Mauro Giovanni; Carpiniello, Bernardo; Piras, A.; Macciò, M. V.; Marcia, Lobsang

doi:10.1016/0924-977x(95)00037-p

Cited by 15 publications

(9 citation statements)

References 7 publications

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“…Sample prevalence estimates were calculated as the proportion of cases in each subset. Population prevalence estimates were derived from the literature 48 – 50 . Prevalence estimates used in GCTA-GREML and LDSC are given in Supplementary Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

et al. 2018

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Few replicable genetic associations for Major Depressive Disorder (MDD) have been identified. Recent studies of MDD have identified common risk variants by using a broader phenotype definition in very large samples, or by reducing phenotypic and ancestral heterogeneity. We sought to ascertain whether it is more informative to maximize the sample size using data from all available cases and controls, or to use a sex or recurrent stratified subset of affected individuals. To test this, we compared heritability estimates, genetic correlation with other traits, variance explained by MDD polygenic score, and variants identified by genome-wide meta-analysis for broad and narrow MDD classifications in two large British cohorts - Generation Scotland and UK Biobank. Genome-wide meta-analysis of MDD in males yielded one genome-wide significant locus on 3p22.3, with three genes in this region (CRTAP, GLB1, and TMPPE) demonstrating a significant association in gene-based tests. Meta-analyzed MDD, recurrent MDD and female MDD yielded equivalent heritability estimates, showed no detectable difference in association with polygenic scores, and were each genetically correlated with six health-correlated traits (neuroticism, depressive symptoms, subjective well-being, MDD, a cross-disorder phenotype and Bipolar Disorder). Whilst stratified GWAS analysis revealed a genome-wide significant locus for male MDD, the lack of independent replication, and the consistent pattern of results in other MDD classifications suggests that phenotypic stratification using recurrence or sex in currently available sample sizes is currently weakly justified. Based upon existing studies and our findings, the strategy of maximizing sample sizes is likely to provide the greater gain.

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Section: Methodsmentioning

confidence: 99%

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

et al. 2018

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“…Also, results of an independent general population survey in Sardinia revealed as well a high lifetime prevalence (6 . 9%) of RBD associated with an increased suicide risk and alcohol abuse (Altamura et al 1995). However, a contradictory low clinical prevalence rate (2 %) was reported in the DSM-IV Mood Disorder Field Trial (Keller et al 1995).…”

Section: Concept and Previous Findingsmentioning

confidence: 99%

Recurrent brief depressive disorder reinvestigated: a community sample of adolescents and young adults

Pezawas

Wittchen

Angst³

et al. 2003

Psychol. Med.

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“…Several of these studies [ 8 - 10 ] as well as research in primary care settings [ 11 ] have also revealed a substantial proportion of individuals that have mood or anxiety symptoms not meeting diagnostic criteria for corresponding disorders. Although, clinical and a small number of epidemiological studies have supported the clinical significance of these syndromes [ 10 , 12 - 15 ] there is still an ongoing debate on whether or not these syndromes require treatment [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors

Waeber²,

et al. 2009

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Background: The Psychiatric arm of the population-based CoLaus study (PsyCoLaus) is designed to: 1) establish the prevalence of threshold and subthreshold psychiatric syndromes in the 35 to 66 year-old population of the city of Lausanne (Switzerland); 2) test the validity of postulated definitions for subthreshold mood and anxiety syndromes; 3) determine the associations between psychiatric disorders, personality traits and cardiovascular diseases (CVD), 4) identify genetic variants that can modify the risk for psychiatric disorders and determine whether genetic risk factors are shared between psychiatric disorders and CVD. This paper presents the method as well as sociodemographic and somatic characteristics of the sample.

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Lifetime prevalence of brief recurrent depression (results from a community survey)

Cited by 15 publications

References 7 publications

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

Recurrent brief depressive disorder reinvestigated: a community sample of adolescents and young adults

The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors

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