The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors

Preisig, Martin; Waeber, Gérard; Vollenweider, Péter; Bovet, Pascal; Rothen, Stéphane; Vandeleur, Caroline L.; Guex, Patrice; Middleton, Lefkos; Waterworth, Dawn; Mooser, Vincent; Tozzi, Federica; Muglia, Pierandrea

doi:10.1186/1471-244x-9-9

Cited by 195 publications

(223 citation statements)

References 76 publications

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“…Such an association with the BMI was not observed in the whole PsyCoLaus sample, but CRTC1 SNPs were associated with BMI in the Radiant study. BMI may less accurately capture adiposity than estimated fat mass using bioimpedance (Marques-Vidal et al, 2009;Prentice and Jebb, 2001). Using the whole CoLaus sample, previous work established that fat mass enables capture of 3 times more subjects with high cardiovascular risk than BMI(Marques-Vidal et al, 2009) and we also showed that this sample is better powered to detect an association of the rs6510997C>T SNP with fat mass than with BMI (Choong et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a genome-wide association study was performed in all Caucasians (91% of the sample). All participants of CoLaus were asked to also participate in the psychiatric evaluations (PsyCoLaus (Preisig et al, 2009)), which included the semi-structured Diagnostic Interview for Genetic Studies (DIGS) (Nurnberger et al, 1994;Preisig et al, 1999). The assignment of the lifetime diagnosis of MDD and the subtyping into atypical and non-atypical MDD was performed according to DSM-IV criteria.…”

Section: Discovery Cohort: Colaus|psycolausmentioning

confidence: 99%

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Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression

Quteineh¹,

Preisig²,

Rivera

et al. 2016

Journal of Affective Disorders

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Philippe Conus and Chin B. Eap, Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression, Journal of Affective Disorders, http://dx.doi.org/10. 1016/j.jad.2016.03.031 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Section: Discovery Cohort: Colaus|psycolausmentioning

confidence: 99%

Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression

Quteineh¹,

Preisig²,

Rivera

et al. 2016

Journal of Affective Disorders

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“…In addition to demographic features, the French version of the DIGS comprises information on a broad spectrum of DSM-IV Axis I disorders as well as on some Axis II criteria and suicide behavior (Preisig, et al, 2009). According to the DIGS participants were coded as having an AUD if they met criteria for either alcohol abuse or dependence according to the DSM-IV at any point of their lives.…”

Section: Methodsmentioning

confidence: 99%

Posttraumatic stress avoidance symptoms as mediators in the development of alcohol use disorders after exposure to childhood sexual abuse in a Swiss community sample

Müller¹,

Vandeleur

Rodgers³

et al. 2015

Child Abuse & Neglect

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This study examined the role of posttraumatic stress disorder (PTSD) symptoms of reexperience, avoidance, and hyperarousal in the relationship between different types of trauma and alcohol use disorders (AUD). We used data from 731 trauma-exposed individuals who participated in the first wave of the PsyCoLaus-study. Trauma characteristics were assessed relatively to the occurrence of lifetime PTSD symptoms and AUD. The results suggest that lifetime and childhood sexual abuse as well as overall childhood trauma were directly linked to AUD and PTSD symptoms, in particular to avoidance symptoms. From single symptom clusters PTSD avoidance was found to specifically mediate the trauma-AUD pathway. Both childhood and sexual trauma strongly contribute to the comorbidity of PTSD and AUD and avoidance-type symptoms appear to play a central role in maintaining this association. Hence, the alleviation of avoidance symptoms might be an important target for therapeutic intervention among victims of sexual abuse before specific addiction treatment is initiated.

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“…The HypnoLaus Sleep Cohort study included participants of the population-based CoLaus/PsyCoLaus Cohort study described previously [9,10]. Briefly, the CoLaus/PsychoLaus study included a random sample of 6,734 participants (age range: 35-75 years) selected from the residents of Lausanne city (Switzerland) between 2003 and 2006.…”

Section: Participantsmentioning

confidence: 99%

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

Haba‐Rubio

Frauscher

Marques‐Vidal

et al. 2017

Sleep

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Study Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography.Methods: Full polysomnographic data from 1,997 participants (age = 59 ± 11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD. Full polysomnography was performed at home. For participants screening positive for RBD, muscle activity during REM sleep was quantified to diagnose RBD.Results: Three hundred sixty-eight participants endorsed dream-enactment behavior on either of the two MUPS questions, and 21 fulfilled polysomnographic criteria for RBD, resulting in an estimated prevalence of 1.06% (95% CI = 0.61-1.50), with no difference between men and women. Compared with RBD− participants, RBD+ took more frequently antidepressants and antipsychotics (23.8% vs. 5.4%, p = .005; 14.3% vs. 1.5%, p = .004, respectively) and were more frequently smokers or exsmokers (85% vs. 56.6%, p = .011). On polysomnography, RBD+ had more stage N2 sleep (52 ± 11.5% vs. 46.3 ± 10.2%, p = .024) and less REM sleep (18 ± 6.4% vs. 21.9 ± 6.2%, p = .007), lower apnea-hypopnea index in REM sleep (3.8 ± 5.2 vs. 8.9 ± 13/hour, p = .035), and lower autonomic arousal index (31 ± 14.9 vs. 42.6 ± 19.5/hour, p = .002). Conclusions:In our middle-to-older age population-based sample, the prevalence of RBD was 1.06%, with no difference between men and women. RBD was associated with antidepressant and antipsychotic use and with minor differences in sleep structure.Key words: polysomnography; synucleinopathies; parasomnia; sleep; REM sleep without atonia Statement of SignificanceRapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia frequently associated or preceding neurodegenerative diseases such as synucleinopathies. Its occurrence in the general population is largely unknown. Analyzing data from 1,997 participants to the population-based HypnoLaus study who completed the Munich Parasomnia Screening questionnaire and had a complete polysomnography at home, we estimate the prevalence of RBD at 1.06%, with no significant difference between men and women. RBD was associated with antidepressant and antipsychotic use, and with minor differences in sleep structure. Knowing the prevalence and characteristics of RBD has important implications, as people with RBD can be ideal candidates for neuroprotective approaches, and can help us to better understand the progression of neurodegenerative disorders.

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The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors

Cited by 195 publications

References 76 publications

Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression

Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression

Posttraumatic stress avoidance symptoms as mediators in the development of alcohol use disorders after exposure to childhood sexual abuse in a Swiss community sample

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

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