1996
DOI: 10.1136/bmj.312.7046.1569
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Lifetime exposure to environmental lead and children's intelligence at 11-13 years: the Port Pirie cohort study

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Cited by 181 publications
(125 citation statements)
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“…3 Starting at approximately 12 weeks of gestation, lead can cross the placenta so that the levels in mother and baby become identical. Although only a few pregnant women in the United States are exposed to very high lead levels, the lack of a sufficient brain barrier for lead in the developing fetus causes even lower levels to have adverse effects on neurodevelopment [25][26][27] with subsequent behavioral and learning problems later in life.…”
Section: Lead Toxicity and Pregnancymentioning
confidence: 99%
“…3 Starting at approximately 12 weeks of gestation, lead can cross the placenta so that the levels in mother and baby become identical. Although only a few pregnant women in the United States are exposed to very high lead levels, the lack of a sufficient brain barrier for lead in the developing fetus causes even lower levels to have adverse effects on neurodevelopment [25][26][27] with subsequent behavioral and learning problems later in life.…”
Section: Lead Toxicity and Pregnancymentioning
confidence: 99%
“…Ker je centralni `iv~ni sistem posebej ob~utljiv na pomanjkanje kisika, so posledice vnosa pove~ane koli~ine svinca vidne celo pred pojavom simptomov slabokrvnosti (8).Zaradi ob~utljivosti zarodkovega `iv~nega sistema na svinec uvr{~amo med zelo ogro`ene skupine prebivalstva tudi matere v ~asu nose~nosti. O pojavu motenega psihi~nega razvoja otrok ob vsebnosti svinca v krvi zarodka oziroma novorojenca v vrednosti 100 μg/l krvi poro~ajo {tevilni raziskovalci (9)(10)(11)(12), hipotezo pa je potrdila tudi prospektivna epidemiolo{ka {tudija (13). Poleg tega so raziskave pokazale, da je prezgodnje rojstvo bolj verjetno, ~e je koncentracija svinca pri materi med 100 in 150 μg/l krvi.…”
Section: Metodeunclassified
“…Long-term prospective studies suggest that the adverse neurodevelopmental effects of prenatal lead exposure may not persist into adolescence if early postnatal exposure falls to background levels (Bellinger et al 1990(Bellinger et al , 1992Tong et al 1996). However, maternal BLL measured during pregnancy has been associated with alterations in brainstem auditory response at in the offspring at age five (Rothenberg et al 2000), and in retinal response at age 10 (Rothenberg et al 2002b).…”
Section: Pregnancy and Breast Feeding Concernsmentioning
confidence: 99%