Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors

Callahan, Catherine L.; Bonner, Matthew R.; Nie, Jing; Han, Daikwon; Wang, Youjin; Tao, Meng Hua; Shields, Peter G.; Marian, Cătălin; Eng, Kevin H.; Trevisan, Maurizio; Beyea, Jan; Freudenheim, Jo L.

doi:10.1016/j.envres.2017.11.040

Cited by 32 publications

(27 citation statements)

References 68 publications

(78 reference statements)

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“…NO 2 and PM 10 concentrations were significantly and positively associated with the breast cancer incidence rate in South Korean female population. This result is consistent with previous studies that reported significantly higher risk of breast cancer incidence 5,7,9,11 , and is partly consistent with studies that reported suggestive 6,8,10,12,14,15,27 or null 11,[21][22][23]28 associations between air pollutants and breast cancer. Our study adds evidence of a significant positive association to the aforementioned studies.…”

Section: Discussionsupporting

confidence: 93%

“…This adds a new layer of evidence for the association between air pollution and breast cancer incidence rates to the previous studies that had case-control or cohort settings. Differences in the significance of the positive association in our study and www.nature.com/scientificreports www.nature.com/scientificreports/ aforementioned studies may be due to the relatively severer air pollution in South Korea (Table 1) compared with the air pollution measured in European 10,23 or North American cohorts 6,8,11,14,22,27 . If so, countries with severe air pollution, such as China or India, may also exhibit significant positive associations that are similar to our result.…”

Section: Discussioncontrasting

confidence: 70%

“…In addition, subsequent studies will be needed to uncover the underlying physiological mechanisms and pathways in these associations. As previous studies [14][15][16]19 suggest, NO 2 and PM 10 may exert both endocrine-disrupting and carcinogenic properties. Regions with severe air pollution may co-localize with other endocrine-disrupting agents or carcinogens, thereby exhibiting a harmful association with breast cancer incidence.…”

Section: Discussionmentioning

confidence: 57%

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Impact of air pollution on breast cancer incidence and mortality: a nationwide analysis in South Korea

Hwang

Bae

Choi

et al. 2020

Sci Rep

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Breast cancer is one of the major female health problems worldwide. Although there is growing evidence indicating that air pollution increases the risk of breast cancer, there is still inconsistency among previous studies. Unlike the previous studies those had case-control or cohort study designs, we performed a nationwide, whole-population census study. In all 252 administrative districts in South Korea, the associations between ambient no 2 and particulate matter 10 (PM 10) concentration, and age-adjusted breast cancer mortality rate in females (from 2005 to 2016, N mortality = 23,565), and incidence rate (from 2004 to 2013, N incidence = 133,373) were investigated via multivariable beta regression. population density, altitude, rate of higher education, smoking rate, obesity rate, parity, unemployment rate, breastfeeding rate, oral contraceptive usage rate, and Gross Regional Domestic product per capita were considered as potential confounders. Ambient air pollutant concentrations were positively and significantly associated with the breast cancer incidence rate: per 100 ppb CO increase, odds Ratio oR = 1.08 (95% Confidence Interval CI = 1.06-1.10), per 10 ppb NO 2 , oR = 1.14 (95% CI = 1.12-1.16), per 1 ppb SO 2 , oR = 1.04 (95% CI = 1.02-1.05), per 10 µg/m 3 PM 10 , oR = 1.13 (95% ci = 1.09-1.17). However, no significant association between the air pollutants and the breast cancer mortality rate was observed except for PM 10 : per 10 µg/m 3 PM 10 , oR = 1.05 (95% CI = 1.01-1.09). Breast cancer is the most frequently diagnosed cancer among women worldwide 1 , and is rapidly increasing in industrialized countries and urban areas. In South Korea, breast cancer is the second most common after thyroid cancer and has annually increased by 6.1% from 1999 to 2014 2,3. Increased exposure to environmental female hormones is considered to affect the rise of breast cancer incidence. In addition, hormone-dependent cancer is increasing in industrialized countries 1,4. There is growing evidence indicating that air pollution is a risk factor for breast cancer. Nitrogen oxides (NO 2 and NO x) 5-9 , fine particulate matters (PM 10 and PM 2.5) 10,11 , and polycyclic aromatic hydrocarbons (PAHs) 12,13 are reported to associate with breast cancer incidence. The physiological mechanisms by which air pollutants affect breast cancer are largely explained in two ways. First, air pollutants may directly cause genetic mutations, as they are carcinogenic 14,15. Second, air pollutants may affect breast cancer incidence by increasing breast density, which is known to be a risk factor. Yaghjyan et al. reported an association between exposure to PM 2.5 , O 3 , and mammographic breast density 16. Female hormones affect breast density, and some air pollutants are known to exhibit endocrine-disrupting properties, including xenoestrogens 17. However, in the Danish Diet, Cancer and Health cohort (1993-1997) study, little evidence of association between traffic-related air pollution exposure and breast density was found 18. Hung et al. reported ...

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 57%

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Impact of air pollution on breast cancer incidence and mortality: a nationwide analysis in South Korea

Hwang

Bae

Choi

et al. 2020

Sci Rep

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“…Our inference is that the best way to accomplish a reliable and effective study is follow a combination of various methodologies of quantitative and qualitative research. We therefore conclude that, the most appropriate methods in our study are a mixture of qualitative, quantitative research, longitudinal and cross-sectional research and classification research [1,5,8,11,13,21,23,29,32,33,42,48,52,53,76,79,91,92,95,98,106,113,124,126,129,136,140,142].…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study of an Online Intelligent Environmental Observation System for Monitoring and Evaluating Public Health Hazard from Indoor and Outdoor Pollutants

Kanellopoulos¹,

Ανδρικόπουλος²,

Koutsojannis³

2019

AJEP

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The overall aim of this research is the prevention of environmental risk and impact, through the establishment of a present-day environmental observatory centre, equipped with an intelligent monitoring, management and evaluating system. Detecting the environmental pollutants in a timely manner (forecasting), potentially related to adverse health effects while their frequency appears to have increased, shall contribute crucially to avoiding or reducing further inhabitants' exposure to pollutants in high environmental charging areas. A plurality of data will be collected and analyzed in the pilot Observatory. All these data will be gathered by measuring various environmental parameters (physicochemical, microbiological, ionized and not ionized radiation, dust, noise), a number of which will be transmitted wireless from small scale monitoring stations. The data base (territorial distribution of samples, number and frequency of sampling, analyze results, toxicity and risk indicators of environmental pollutants), will be enriched daily/weekly, with satellite data, meteorological data and satellite photographs (image analysis). With the collection, processing and analysis of measured values for various kinds of pollutants from environmental overloaded surfaces, useful conclusions are drawn regarding to the "pollution tendency" in every different area and the possible effects on human in combination with geography and geomorphology. With the use of artificial intelligence (AI) in human body simulators (whole body phantom models) we intend to make a more accurate qualitative and quantitative forecast: worst-best scenario, about as the life quality for residents-who may be exposed to the pollutants-as the direct or indirect medium to long-term adverse effects.

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“…On the other hand, when it evaluated the difference between levels of methylation by age groups no significant results were found (20–39 years old: 42.04 ± 19.12, 40–59 years old: 41.40 ± 17.27; p = 0.9310; Mann–Whitney); (20–30 years old: 39.95 ± 18.63, 31–40 years old: 45.70 ± 19.60, 41–50 years old: 44.39 ± 17.28, 51–59 years old: 39.10 ± 17.04; p = 0.1338; Kruskal–Wallis). Indeed, the literature shows that in spite of external factors such as diet [ 18 ], smoking [ 26 ], alcohol consumption [ 27 ] and air pollution [ 28 ], inner factors such as age and gender have also influence on the DNA methylation profile. Differences in the profile of DNA methylation between males and female have already been observed in skin for miR - 137 gene [ 29 ] and in buccal cells for MMP9 and TIMP - 1 genes [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Decrease of the DNA methylation levels of the ADRB3 gene in leukocytes is related with serum folate in eutrophic adults

et al. 2018

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BackgroundDNA methylation has been evidenced as a potential epigenetic mechanism related to various candidate genes to development of obesity. Therefore, the objective of this study was to evaluate the DNA methylation levels of the ADRB3 gene by body mass index (BMI) in a representative adult population, besides characterizing this population as to the lipid profile, oxidative stress and food intake.MethodsThis was a cross-sectional population-based study, involving 262 adults aged 20–59 years, of both genders, representative of the East and West regions of the municipality of João Pessoa, Paraíba state, Brazil, in that were evaluated lifestyle variables and performed nutritional, biochemical evaluation and DNA methylation levels of the ADRB3 gene using high resolution melting method. The relationship between the study variables was performed using analyses of variance and multiple regression models. All results were obtained using the software R, 3.3.2.ResultsFrom the stratification of categories BMI, was observed a difference in the average variables values of age, waist-to-height ratio, waist-to-hip ratio, waist circumference, triglycerides and intake of trans fat, which occurred more frequently between the categories “eutrophic” and “obesity”. From the multiple regression analysis in the group of eutrophic adults, it was observed a negative relationship between methylation levels of the ADRB3 gene with serum levels of folic acid. However, no significant relation was observed among lipid profile, oxidative stress and food intake in individuals distributed in the three categories of BMI.ConclusionsA negative relationship was demonstrated between methylation levels of the ADRB3 gene in eutrophic adults individuals with serum levels of folic acid, as well as with the independent gender of BMI, however, was not observed relation with lipid profile, oxidative stress and variables of food intake. Regarding the absence of relationship with methylation levels of the ADRB3 gene in the categories of overweight, mild and moderate obesity, the answer probably lies in the insufficient amount of body fat to initiate inflammatory processes and oxidative stress with a direct impact on methylation levels, what is differently is found most of the times in exacerbated levels in severe obesity.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1529-0) contains supplementary material, which is available to authorized users.

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Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors

Cited by 32 publications

References 68 publications

Impact of air pollution on breast cancer incidence and mortality: a nationwide analysis in South Korea

Impact of air pollution on breast cancer incidence and mortality: a nationwide analysis in South Korea

A Pilot Study of an Online Intelligent Environmental Observation System for Monitoring and Evaluating Public Health Hazard from Indoor and Outdoor Pollutants

Decrease of the DNA methylation levels of the ADRB3 gene in leukocytes is related with serum folate in eutrophic adults

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