Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae

Menzies, Nicolas A; Quaife, Matthew; Allwood, Brian; Byrne, Anthony; Coussens, Anna K.; Harries, Anthony; Marx, Florian M.; Meghji, Jamilah; Pedrazzoli, Debora; Salomon, Joshua A.; Sweeney, Sedona; Kampen, Sanne van; Wallis, Robert S.; Houben, Rein M. G. J.; Cohen, Ted

doi:10.1016/s2214-109x(21)00367-3

Cited by 97 publications

(90 citation statements)

References 27 publications

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“…From 2004 to 2013, the three infectious diseases with the highest incidence were hand, foot, and mouth disease, hepatitis B and tuberculosis in China [4] , [5] . Hand, foot, and mouth disease was particularly widespread in Asia and was estimated to cause 96 900 age-weighted Disability Adjusted Life Years (DALYs) per annum in eight high-burden countries in East and Southeast Asia [6] ; HBV accounted for 700 000 deaths and 21.8 million DALYs globally during 2007–2017, of which East Asia was the worst [7] ; Tuberculosis was estimated to cause 122 million DALYs globally in 2019, of which countries in Southeast Asia and Africa were more serious [8] . Influenza was the main cause of morbidity and mortality worldwide, including in China [9] , and the disease burden of influenza was beyond respiratory illness [10] .…”

Section: Introductionmentioning

confidence: 99%

Incidence trend and disease burden of seven vaccine-preventable diseases in Shandong province, China, 2013–2017: Findings from a population-based observational study

Yin

Wang

et al. 2022

Vaccine: X

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Section: Introductionmentioning

confidence: 99%

Incidence trend and disease burden of seven vaccine-preventable diseases in Shandong province, China, 2013–2017: Findings from a population-based observational study

Yin

Wang

et al. 2022

Vaccine: X

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“…Inclusion of data on the long-term sequelae of TB can substantially affect assessments of TB burden [ 35 ], and those developing TB during childhood or adolescence may contribute disproportionately to life-years lived with disability of reduced health-related quality of life [ 36 ]. In particular, TB meningitis leads to neurological sequelae in an estimated 54% of children and adolescents who survive the illness [ 33 ].…”

Section: Progress Towards the Un Hlm Meeting Targets For 2018–2022mentioning

confidence: 99%

Addressing the Data Gaps on Child and Adolescent Tuberculosis

Verkuijl

Sekadde²,

Dodd

et al. 2022

Pathogens

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The burden of tuberculosis (TB) among children and young adolescents (<15 years old) is estimated at 1.1 million; however, only 400,000 are treated for TB, indicating a large gap between the number who are cared for and the number estimated to have TB. Accurate data on the burden of pediatric TB is essential to guide action. Despite several improvements in estimating the burden of pediatric TB in the last decade, as well as enhanced data collection efforts, several data gaps remain, both at the global level, but also at the national level where surveillance systems and collaborative research are critical. In this article, we describe recent advances in data collection and burden estimates for TB among children and adolescents, and the remaining gaps. While data collection continues to improve, burden estimates must evolve in parallel, both in terms of their frequency and the methods used. Currently, at the global level, there is a focus on age-disaggregation of TB notifications, the collection of data on TB-HIV, multi-drug resistant (MDR)-TB and treatment outcomes, as well as estimates of the disease burden. Additional data from national surveillance systems or research projects on TB meningitis, as well as other forms of extra-pulmonary TB, would be useful. We must capitalize on the current momentum in child and adolescent TB to close the remaining data gaps for these age groups to better understand the epidemic and further reduce morbidity and mortality due to TB.

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“…They continue to suffer from long-term functional disability and reduced quality of life due to permanent lung damage. These sequelae arise from excessive and aberrant host immune and inflammatory responses to M.tb resulting in extensive tissue destruction (Menzies NA et al, 2022;Allwood BW et al,2022;Frank DJ et al, 2019;Rao et al 2021;Maeurer M et al, 2021;Shaw et al, 2021). For more holistic treatment of TB a range of Host-Directed Therapies (HDTs) with various mechanisms of action to enhance immune responses or reduce excessive inflammation, are being considered for use as adjunct therapy in addition to anti-TB drug treatment regimens.…”

Section: Host-drected Therapies For Tuberculosis Managementmentioning

confidence: 99%

Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections.

Ntoumi¹,

Petersen²,

Mwaba³

et al. 2022

International Journal of Infectious Diseases

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Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae

Cited by 97 publications

References 27 publications

Incidence trend and disease burden of seven vaccine-preventable diseases in Shandong province, China, 2013–2017: Findings from a population-based observational study

Incidence trend and disease burden of seven vaccine-preventable diseases in Shandong province, China, 2013–2017: Findings from a population-based observational study

Addressing the Data Gaps on Child and Adolescent Tuberculosis

Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections.

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