Lifestyle factors and the risk of adult leukemia in Canada

Kasim, Khaled; Levallois, Patrick; Abdous, Belkacem; Auger, Pierre; Johnson, Kenneth C.

doi:10.1007/s10552-004-7115-1

Cited by 79 publications

(88 citation statements)

References 28 publications

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“…A statistically significant increased risk (OR=1.5) for acute myeloid leukemia associated with active smoking (Kasim, 2005). A similar outcome was reported by an US cohort study and the risk enhanced for heavy smokers (Xiaomei, 2009).…”

Section: Discussionsupporting

confidence: 81%

“…Studies on dietary factors and AML are scarce and usually include a small number of cases. A large case-control study, did not observe any association between intake of fruits and vegetables and the risk of adult leukemia overall (1,068 cases) or AML in particular (307 cases) (Kasim, 2005;Xiaomei, 2009). No association was observed with intake of fruits, vegetables (Xiaomei, 2009).…”

Section: Discussionmentioning

confidence: 92%

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Lifestyle Factors Including Diet and Leukemia Development: a Case-Control Study from Mumbai, India

Ganesh

Saoba²,

Sarhade³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 92%

Lifestyle Factors Including Diet and Leukemia Development: a Case-Control Study from Mumbai, India

Ganesh

Saoba²,

Sarhade³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Only 0.11% (0.05%-0.26%) of inhaled benzene is metabolized to SPMA, which has a short half-life; mean ranges from 9 to 13 hours (39)(40)(41). Cigarette smoking is regarded as a source of benzene intake and an established risk factor for adult acute myelogenous leukemia (42)(43)(44)(45)(46)(47)(48)(49). Cigarette smokers have elevated excretion of SPMA, as much as ten times higher than non-smokers (50).…”

Section: Introductionmentioning

confidence: 99%

Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications

Kassem

Jackson

Liles

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Benzene is a human hematotoxicant and a leukemogen that causes lymphohematopoietic cancers, especially acute myelogenous leukemia. We investigated uptake of benzene in hookah smokers and non-smokers attending hookah social events in naturalistic settings where hookah tobacco was smoked exclusively.Methods: We quantified S-phenylmercapturic acid (SPMA), a metabolite of benzene, in the urine of 105 hookah smokers and 103 non-smokers. Participants provided spot urine samples the morning of and the morning after attending an indoor hookah-only smoking social event at a hookah lounge or in a private home.Results: Urinary SPMA levels in hookah smokers increased significantly following a hookah social event (P < 0.001). This increase was 4.2 times higher after hookah lounge events (P < 0.001) and 1.9 times higher after home events (P ¼ 0.003). In non-smokers, urinary SPMA levels increased 2.6 times after hookah lounge events (P ¼ 0.055); however, similar urinary SPMA levels were detected before and after home events, possibly indicating chronic exposure to benzene (P ¼ 0.933).Conclusions: Our data provide the first evidence for uptake of benzene in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke at social events in private homes compared with their counterparts in hookah lounges. Hookah tobacco smoke is a source of benzene exposure, a risk factor for leukemia.Impact: Because there is no safe level of exposure to benzene, our results call for interventions to reduce or prevent hookah tobacco use, regulatory actions to limit hookah-related exposure to toxicants including benzene, initiate labeling of hookah-related products, and include hookah smoking in clean indoor air legislation. Cancer Epidemiol Biomarkers Prev; 23(12); 2793-809. Ó2014 AACR.

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“…Several reports on body mass index (BMI) and leukemias and MM suggest that there may be a weak positive association (19)(20)(21)(22). However, there is no conclusive evidence as other studies have failed to confirm such a relationship (23,24).…”

Section: Introductionmentioning

confidence: 99%

Tobacco Use, Body Mass Index, and the Risk of Leukemia and Multiple Myeloma: A Nationwide Cohort Study in Sweden

et al. 2007

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In a prospective cohort study of more than 330,000 Swedish construction workers, we explored the effect of tobacco smoking, oral moist snuff use, and body mass index (BMI) on the risk of developing leukemia (excluding chronic lymphocytic leukemia) and multiple myeloma (MM). Study subjects were participants of a health surveillance system within the building industry. Record linkage to the nationwide Swedish cancer registry, migration registry, and cause of death registry made a comprehensive follow-up available.

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Lifestyle factors and the risk of adult leukemia in Canada

Abstract: Our study contributes to the accumulating evidence linking AML and active smoking, and provides some evidence that obesity increases the risk of most of the adult leukemia subtypes.

Cited by 79 publications

References 28 publications

Lifestyle Factors Including Diet and Leukemia Development: a Case-Control Study from Mumbai, India

Lifestyle Factors Including Diet and Leukemia Development: a Case-Control Study from Mumbai, India

Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications

Tobacco Use, Body Mass Index, and the Risk of Leukemia and Multiple Myeloma: A Nationwide Cohort Study in Sweden

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