Lifestyle differences in twin pairs discordant for basal cell carcinoma of the skin

Milán, T.; Verkasalo, Pia K.; Kaprio, Jaakko; Koskenvuo, Markku

doi:10.1046/j.1365-2133.2003.05352.x

Cited by 88 publications

(118 citation statements)

References 24 publications

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“…Therefore, high solar UVB radiation levels imply a great capability to synthesize vitamin D in the northern regions of Chile. A recent analysis determined that the diagnosis of NMSC was associated with a reduced risk of several vitamin D-sensitive cancers (30,31). This was in accordance with low solar UVB radiation levels in the southern cities of Chile in winter.…”

Section: Discussionmentioning

confidence: 59%

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

et al. 2017

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Abstract. Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument. The results, which are presented in the current study, showed the association between NMSC and MSC rates, and the time required to produce 1,000 IU vitamin D with latitudinal variation. Solar UV index (UVI) levels reported in 6 cities from the north to the south of Chile indicated that the UVI ratio of monthly mean values was 1.8 times higher in Arica than in Punta Arenas in January (summer in Chile), whereas it was 14 times higher in June (winter). This factor is an important consideration, since vitamin D synthesis is directly associated with the exposure of individuals to solar UVB radiation. A similar trend was observed in Antofagasta, Santiago, Concepcion, Valdivia and Punta Arenas. It can be concluded from these data that there is a direct association between NMSC rates and mortality, and UVB radiation, meaning that this type of cancer would not depend on vitamin D synthesis and therefore on calcium uptake. By contrast, MSC rates increased with decreased levels of vitamin D, and thus calcium uptake, in all cities, with the only exception being Punta Arenas.

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Section: Discussionmentioning

confidence: 59%

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

et al. 2017

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“…Still, a limited number of epidemiological studies investigated its etiological factors. Sunlight exposure and a history of sunburns contribute to a large proportion of BCC in white populations, but several other factors have been suggested [6,7,8,9]. …”

Section: Introductionmentioning

confidence: 99%

Anthropometric Measures, Medical History and Risk of Basal Cell Carcinoma in an Italian Case-Control Study

et al. 2008

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Background/Aims: A few epidemiological studies investigated etiological factors for basal cell carcinoma (BCC) other than sunlight exposure and sunburns. Information on anthropometric measures and medical history is scant. Methods: We examined the issue in a case-control study including 528 patients with incident, histologically confirmed BCC and 512 controls hospitalized with acute conditions. Results: Odds ratios (OR) for the highest versus the lowest quartiles were 0.77 for weight, 0.99 for height, 0.87 for body mass index and 0.81 for body surface area. Corresponding estimates for trunk BCC were 0.42, 0.81, 0.50 and 0.47. Subjects with asthma (OR = 0.26) and diabetes mellitus (OR = 0.23) showed a decreased risk of trunk BCC but not face and neck BCC. Conclusion: The inverse relations between trunk, but not face and neck BCC, and obesity, diabetes mellitus and asthma may indirectly reflect the different role of past sunlight exposure to different body locations and variable etiologic pathways for BCCs according to body areas.

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“…Prior to the approval of TCIs we preformed a case-control study which demonstrated that the odds ratio (OR) of association of NMSC in patients with AD was either the same or slightly less than in those with other inflammatory dermatologic illnesses [11]. A study of twins also showed that the development of basal cell carcinoma was not associated with AD [12]. However, a recent study from Sweden indicated that patients hospitalized for AD had a trend, which was not statistically significant, toward a 50% increase in skin cancers about 15 years later in life [13].…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Exposure to Topical Calcineurin Inhibitors and Skin Cancer in Adults

2007

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Background: Two topical calcineurin inhibitors (TCI) are available for the treatment of atopic dermatitis and there has been concern that their use could be associated with an increased risk of nonmelanoma skin cancer (NMSC). Objective: To determine if TCI exposure is associated with an increased risk of NMSC in adults. Methods: A case-control study using a questionnaire mailed to 5,000 adults with dermatitis. Results: We received responses from 70.7% of those surveyed by mail. Overall, 25.7% reported exposure to TCI. TCI exposure was 14.4% for the cases and 30.7% for the controls. Our primary analysis was a comparison between those with NMSC and those without. The unadjusted odds ratio was 0.38 (0.31–0.47) and the adjusted (age, gender, previous NMSC, history of atopic dermatitis) was 0.54 (0.41–0.69). The odds ratio of association for NMSC decreased as the number of tubes used and the potency of the agent increased. Conclusion: This early study shows that TCI use is not associated with an increased risk of NMSC in adults.

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Lifestyle differences in twin pairs discordant for basal cell carcinoma of the skin

Abstract: The results suggest a role for smoking and possibly also for other lifestyle factors in the risk of contracting BCC.

Cited by 88 publications

References 24 publications

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

Anthropometric Measures, Medical History and Risk of Basal Cell Carcinoma in an Italian Case-Control Study

Lack of Association between Exposure to Topical Calcineurin Inhibitors and Skin Cancer in Adults

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