Lifestyle and normal hearing function in Italy and Central Asia: The potential role of coffee

Vuckovic, Dragana; Biino, Ginevra; Panu, Francesco; Pirastu, Mario; Gasparini, Paolo; Girotto, Giorgia

doi:10.3109/21695717.2013.817134

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Another study conducted using a rat model of cisplatin ototoxicity suggested that caffeine consumption may exacerbate cisplatin-induced hearing loss 5 . Contradictorily, two investigations reported lower prevalence of hearing loss in coffee consumers 2 , 3 . Another study reported the protective effect of chocolate-based diet on hearing loss 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Second, it should be noted that besides the challenge in calculating caffeine intake from food, the common food (e.g., coffee and chocolate) for study caffeine contain agents other than caffeine. Coffee has high levels of different polyphenols with antioxidant and anti-inflammatory effects which can protect against oxidative-related disorders, including age-related hearing loss 3 , 18 – 20 ; polyphenols, phenethyl ester, and other bioactive phytochemicals in coffee have been demonstrated protective effects against ototoxicity in the peripheral auditory system 8 , 21 , 22 . However, caffeine was reported to have the opposite effect.…”

Section: Discussionmentioning

confidence: 99%

“…However, studies investigating the relationship between caffeine and hearing loss are contradictory. Two studies reported lower prevalence of hearing loss in coffee consumers 2 , 3 . Another study reported that chocolate-based diet may protect middle-aged people from hearing loss 4 .…”

Section: Introductionmentioning

confidence: 99%

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Urine caffeine metabolites and hearing threshold shifts in US adults: a cross-sectional study

Long

Tang

2021

Sci Rep

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Previous studies have reported the relationship between effect of caffeine and many diseases. However, studies to evaluate the association between caffeine and hearing loss are contradictory. To examine the relationship of urinary caffeine metabolites with the hearing threshold in US adults, a total of 849 adults aged 20–69 years who participated in the National Health and Nutrition Examination Survey (NHANES, 2011–2012) were enrolled in this study. Urinary caffeine and its 14 metabolites were applied as biomarkers to assess caffeine exposure. Hearing loss was defined as mean pure tone averages > 25 dB HL at 500, 1000, and 2000 Hz in both ears (low frequency); and 3000, 4000, and 6000 Hz in both ears (high frequency). Univariate and multivariate linear regression analyses were conducted to examine the associations of urinary caffeine metabolites with low- and high-frequency hearing thresholds, respectively. Low-frequency hearing loss were 5.08% and 6.10% in male and female participants, respectively; and high-frequency hearing loss were 31.81% and 15.14% in male and female participants, respectively. In the unadjusted model, the P value for trend shows that urinary caffeine metabolites 137X and AAMU were significantly associated with low-frequency PTA, and that 17X, 137X, AAMU were significantly associated with high-frequency PTA, but when the model was adjusted for sex, age, education level, firearm noise exposure, occupational noise exposure, recreational noise exposure, serum cotinine, body mass index, diabetes, hypertension, these were no longer statistically significant. In conclusion, urinary caffeine metabolites were not associated with the hearing threshold shifts in US adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Urine caffeine metabolites and hearing threshold shifts in US adults: a cross-sectional study

Long

Tang

2021

Sci Rep

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“…It is a complex disease in which genetic and environmental risk factors (i.e., noise, smoking, alcohol, etc.) interplay (Bovo et al, 2011; Ohgami et al, 2013; Vuckovic et al, 2013, 2014). To date, it is still unclear whether ARHL is caused by (1) rare Mendelian gene variants with large effect size or (2) multiple variants each contributing to the disease.…”

Section: Introductionmentioning

confidence: 99%

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

et al. 2019

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Age-related hearing loss (ARHL) is the most common sensory impairment in the elderly affecting millions of people worldwide. To shed light on the genetics of ARHL, a large cohort of 464 Italian patients has been deeply characterized at clinical and molecular level. In particular, 46 candidate genes, selected on the basis of genome-wide association studies (GWAS), animal models and literature updates, were analyzed by targeted re-sequencing. After filtering and prioritization steps, SLC9A3R1 has been identified as a strong candidate and then validated by “ in vitro” and “in vivo” studies. Briefly, a rare (MAF: 2.886e-5) missense variant c.539G > A, p.(R180Q) was detected in two unrelated male patients affected by ARHL characterized by a severe to profound high-frequency hearing loss. The variant, predicted as damaging, was not present in healthy matched controls. Protein modeling confirmed the pathogenic effect of p.(R180Q) variant on protein’s structure leading to a change in the total number of hydrogen bonds. In situ hybridization showed slc9a3r1 expression in zebrafish inner ear. A zebrafish knock-in model, generated by CRISPR-Cas9 technology, revealed a reduced auditory response at all frequencies in slc9a3r1 R180Q/R180Q mutants compared to slc9a3r1 +/+ and slc9a3r1 +/R180Q animals. Moreover, a significant reduction (5.8%) in the total volume of the saccular otolith (which is responsible for sound detection) was observed in slc9a3r1 R180Q/R180Q compared to slc9a3r1 +/+ ( P = 0.0014), while the utricular otolith, necessary for balance, was not affected in agreement with the human phenotype. Overall, these data strongly support the role of SLC9A3R1 gene in the pathogenesis of ARHL opening new perspectives in terms of diagnosis, prevention and treatment.

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Role of nutrition in the development and prevention of age-related hearing loss: A scoping review

Rodrigo

Campos-Asensio

Rodríguez

et al. 2021

Journal of the Formosan Medical Association

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Lifestyle and normal hearing function in Italy and Central Asia: The potential role of coffee

Cited by 5 publications

References 21 publications

Urine caffeine metabolites and hearing threshold shifts in US adults: a cross-sectional study

Urine caffeine metabolites and hearing threshold shifts in US adults: a cross-sectional study

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

Role of nutrition in the development and prevention of age-related hearing loss: A scoping review

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