Lifespan and testosterone

Nieschlag, Eberhard; Nieschlag, Susan; Behre, Hermann M.

doi:10.1038/366215a0

Cited by 139 publications

(40 citation statements)

References 2 publications

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“…Earlier it has been questioned whether testosterone has an essential role to play in male physiology. Nieschlag et al, (1993) could not establish that the so-called castrati singers (boys castrated at the very beginning of their puberty to preserve the properties of their boy's voice) lived shorter than noncastrated singers. But recent epidemiological studies have found that low testosterone levels are a predictor of mortality in elderly men (Shores et al, 2004(Shores et al, , 2006Khaw et al, 2007;Maggio et al, 2007;Laughlin et al, 2008).…”

Section: New Perspectives On Testosteronementioning

confidence: 99%

Metabolic syndrome, testosterone deficiency and erectile dysfunction never come alone

2008

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Section: New Perspectives On Testosteronementioning

confidence: 99%

Metabolic syndrome, testosterone deficiency and erectile dysfunction never come alone

2008

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“…Although there is great variability in the decrease in testosterone levels, relative androgen deficiency can be expected to have unfavorable conse quences on muscle, adipose tissue, bone, hematopoiesis and sexual function. However, although correlations be tween testosterone levels, lipid profile and coronary heart disease have been made, there is no evidence that high testosterone levels could explain the difference in life expectancy between men and women and contribute to men's shorter life span [31].…”

Section: Alteration Of Testicular Function In Older Malesmentioning

confidence: 99%

Hormonal Substitution in Older Men

et al. 1995

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The biological bases of endocrine alterations in ageing men are now well identified: progressive impairment of testicular function, decline in growth hormone (GH) secretion with decreased insulin-like growth factor-I (IGF-I) levels, and reduced adrenal androgen secretion. Insulin resistance and glucose intolerance also accompany male ageing. The mechanisms of these age-related changes are still unknown. There are preliminary results on the effects of hormonal replacement therapy in older males with mild hypogonadism or decreased IGF-I levels. Controlled placebo studies will in the future define the risks and benefits of long-term administration of androgens, GH or GH-releasing hormone in these patients. In view of the severe potential side effects, the generalized use of hormonal substitution in elderly men cannot, for the moment, be recommended.

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“…Direct longevity effects of testosterone are limited mostly to castration studies showing that a modest but significant extension of life span is observed in rats while gonadectomy increases the life span of domestic dogs (Drori and Folman, 1976;Michal, 1999). An increase on life span via castration of human males is improbable although one study in institutionalized mentally retarded adults suggests otherwise (Nieschlag et al, 1993;Wilson and Roehrborn, 1999;Hamilton and Mestler, 1969).…”

Section: Testosterone/estrogen/luteinizing Hormone/follicle Stimulatimentioning

confidence: 99%

Hormonal regulation of longevity in mammals

Brown‐Borg

2007

Ageing Research Reviews

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Multiple biological and environmental factors impact the life span of an organism. The endocrine system is a highly integrated physiological system in mammals that regulates metabolism, growth, reproduction, and response to stress, among other functions. As such, this pervasive entity has a major influence on aging and longevity. The growth hormone, insulin-like growth factor-1 and insulin pathways have been at the forefront of hormonal control of aging research in the last few years. Other hormones, including those from the thyroid and reproductive system have also been studied in terms of life span regulation. The relevance of these hormones to human longevity remains to be established, however the evidence from other species including yeast, nematodes, and flies suggest that evolutionarily well-conserved mechanisms are at play and the endocrine system is a key determinant.

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Lifespan and testosterone

Cited by 139 publications

References 2 publications

Metabolic syndrome, testosterone deficiency and erectile dysfunction never come alone

Metabolic syndrome, testosterone deficiency and erectile dysfunction never come alone

Hormonal Substitution in Older Men

Hormonal regulation of longevity in mammals

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