Life psychosocial stresses and coronary artery disease

Abstract

Background:It is hypothesized that the impacts of life events accumulate and can trigger and promote atherosclerosis in susceptible individuals. In the current study, the correlation of total life stressors during 1 year was investigated relative to coronary artery disease (CAD).Methods:The study population consisted of 148 males and 152 females aged 35–76 years. The subjects were classified as CAD cases and controls according to the results of coronary angiography. The severity of CAD was scored on the basis of the number and the extent of lesions at coronary arteries. The stressful events of life were assessed using Holmes-Rahe Questionnaire and was presented as total psychological stress scores per year (TPSS).Results:The frequency of cigarette smoking, diabetes mellitus, and hypertension was more prevalent in CAD cases than control subjects. The levels of TPSS were increased in patients with CAD compared to the controls (160.3 ± 71.3 vs. 139.8 ± 66.5, P = 0.020). TPSS was also associated positively with the levels of uric acid, erythrocytes counts, erythrocyte sedimentation rate, aspirin consumption, and negatively with high-density lipoprotein-cholesterol and apo-AI. In logistic regression analysis, TPSS correlated with the occurrence of CAD by the odds ratio of 1.773 (1.073–2.930), P = 0.025, but the association was weakened after adjustment for classical risk factors, especially hypertension. TPSS exhibited significant association with the severity of CAD [F (3,274) = 2.6, P = 0.051].Conclusions:The results suggest that TPSS are associated with the occurrence and severity of CAD significantly, but the association is not independent.

Cannabis and Tramadol addiction, do they imply paramount hazardous factors for acute myocardial infarction in young adults below 45 years old?

“…Exposure to stressful life as assessed by the Holmes–Rahe Questionnaire recorded 9.4%, 3.8%, 59.4%, and 27.4% had low, normal, moderate, and high stress levels, respectively. In addition, 47.5% of patients with both moderate and high stress levels had other risk factors, such as low HDL level and illicit drug use, indicating a consistent result with the study by Bagheri et al ( 27 ), which showed that total psychological stress is correlated with the existence and severity of CAD considerably, but the correlation was not independent.…”

Chronic Unpredictable Mild Stress Promotes Atherosclerosis via HMGB1/TLR4-Mediated Downregulation of PPARγ/LXRα/ABCA1 in ApoE-/- Mice

“…Accumulating evidence indicates that chronic stress, especially chronic psychological stress, is a critical risk factor for atherosclerotic diseases (Kaplan et al, 1983; Rozanski et al, 1999; Empana et al, 2005; Bagheri et al, 2016). The mechanisms by which chronic stress factors contribute to the development of atherosclerosis are always the research focus (Empana et al, 2005; Everson-Rose et al, 2014; Peplinski et al, 2018).…”

Investigation of Antioxidant Status in Coronary Artery Disease Patients

“…Coronary artery disease (CAD) is an important cardiovascular condition (1), causing 7.4 million deaths annually worldwide (2). As a multifactor disease, CAD is associated with upwards of 250 various risk factors (3). Some of these risk factors are hypertension, hyperlipidemia, diabetes, age, sex, obesity, smoking, and positive family history.…”