Cannabis and Tramadol addiction, do they imply paramount hazardous factors for acute myocardial infarction in young adults below 45 years old?

Mansour, Hazem; Rayan, Mona; Shnoda, Mina; Kamal, Diaa

doi:10.14744/anatoljcardiol.2020.67206

Cited by 2 publications

(6 citation statements)

References 31 publications

(44 reference statements)

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“…According to Maiga et al (2013), tramadol misuse has been associated with organized fights, kidnappings and rapes, murders, and traffic accidents [ 18 ]. In addition, tramadol misuse has been independently associated with adverse cardiovascular effects [ 77 ].…”

Section: Resultsmentioning

confidence: 99%

“…The second category includes professionals such as drivers and their assistants (motorcycle, tricycle, taxi, bus, private car, and truck) [41][42][43][44][45][46][47][48][49][50][51][52], workers in the construction and textile industries [42], skilled workers (hairstylists and mechanics) [53], hospital cleaners [54], and coffee shop workers [55]. The third category includes patients with tramadol dependence or opioid use disorders attributed to tramadol [56][57][58][59][60][61][62][63][64][65], patients with unintentional intoxication [66], patients with substance use disorders or drug addiction [67,68], patients admitted to Neuro-Psychiatric Hospital [69], patients with seizures or psychotic episodes [70,71], treatment-seeking men [72] or trauma victims [73], adults attending family medicine center [74], pharmacy/dispensary customers [75], patients undergoing surgery [76] or admitted for acute myocardial infarction [77], women admitted to addiction treatment center [78], patients attending psychiatric clinic [79][80][81]…”

Section: Subpopulations Affected By Nmu Of Tramadolmentioning

confidence: 99%

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Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review

Boun,

Omonaiye,

Yaya

2024

PLOS Glob Public Health

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Tramadol is a widely prescribed painkiller around the world. As a synthetic opioid, it offers a valuable substitute for morphine and its derivatives in African countries. However, the adverse health effects of tramadol use resulting from illicit trafficking, like those caused by fentanyl and methadone in North America, have not been well-documented in Africa. This scoping review aims to shed light on the nature and scope of the nonmedical use (NMU) of tramadol in Africa and its associated health consequences. To carry out our scoping review, we used Arksey and O’Malley’s (2005) five-step approach for exploratory analysis and followed Joanna Briggs Institute guidelines for scoping reviews to ensure systematic and replicable studies. We then searched six databases: Medline, Global Health (EBSCO), Scopus, Web of Science, the African Journals online database, and for grey literature via Google Scholar without any time restriction. The articles were imported into Covidence and reviewed by two independent researchers. Eighty-three studies on NMU of tramadol’s prevalence or health consequences were selected from 532 titles/abstracts screened, including 60 cross-sectional and six qualitative studies from 10 African countries. Findings from the included studies highlighted five distinct groups significantly affected by the NMU of tramadol. These groups include: 1) young adults/active populations with varying degrees of prevalence ranging from 1.9% to 77.04%, 2) professionals, where drivers exhibit a relatively high prevalence of tramadol NMU, ranging from 7.2% to 35.1%, and commercial motorcyclists, with a prevalence of 76%, 3) patients, who have a high rate of tramadol NMUs, with prevalence rates ranging from 77.1% to 92%, 4) academics, with a considerable rate of tramadol misuse among substance-using undergraduates (74.2%) and substance-using high school students (83.3%), and 5) other individuals impacted in various ways. The health consequences are classified into four distinct types: intoxication, dependence syndrome, withdrawal syndrome and other symptoms. Despite providing a comprehensive global overview of the phenomenon described in the African literature, this systematic scoping review’s main limitations stem from the relatively limited exploration of various consequences of the NMU of tramadol, notably those of a social and economic nature. Our review shows that tramadol misuse affects diverse populations in Africa. The prevalence of misuse varies within sub-populations, indicating the complexity of the issue. Professional and academic groups have different rates of misuse across regions. This highlights the need for targeted interventions to address unique challenges contributing to tramadol misuse. Future studies should focus on the social and economic costs of abuse on households to better understand the impact on well-being. Systematic review registration: Open Science Framework: https://osf.io/ykt25/.

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Section: Resultsmentioning

confidence: 99%

Section: Subpopulations Affected By Nmu Of Tramadolmentioning

confidence: 99%

Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review

Boun,

Omonaiye,

Yaya

2024

PLOS Glob Public Health

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Section: Introductionmentioning

confidence: 99%

“…Acute myocardial infarction (AMI) is the leading worldwide cause of cardiovascular events, and angina is commonly seen before AMI [1,2]. AMI is extremely rare in young patients: in one study in Poland, individuals under age 40 represented only 1-6% of all AMI patients [2][3][4][5]. The rate of incidence has increased over years past in younger patients (< 35 years old) compared to older patients, and the age of onset is gradually falling, likely due to the following multiple risk factors such as smoking, obese, hypertension, diabetes, hyperlipidemia (higher level of low-density lipoprotein-cholesterol (LDL-C)), higher level of uric acid, history of coronary artery disease, family history of premature AMI, non-obstructive coronary artery disease (CAD), and genetic polymorphisms related to blood coagulation, fibrinogen, homocysteine, being present [3,[6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Etiological factors among the younger population are less studied and in patients under age 35 who have AMI, the atherosclerotic burden is very low [2,5,9]. Of these, young ST-elevation AMI (STEMI) patients aged 18 -35 were characterized as being male, obese, smokers, and having a family history of ischemic heart disease, though there is also a prevalence of cardiometabolic risk factors [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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ST-Elevation Acute Myocardial Infarction in a Young Man

Usuda¹,

Tanaka²,

Suzuki³

et al. 2022

J Med Cases

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Acute myocardial infarction (AMI) in young patients is very rare, but the incidence has increased over years past at younger ages, likely due to the presence of multiple risk factors. We present the first known case of ST-elevation AMI (STEMI) in a young man. A 22-year-old Japanese man was transferred to our hospital due to suddenly occurred anterior chest pain. An electrocardiogram revealed ST elevation in anteroseptal leads together with reciprocal ST depression in inferior leads. An emergency coronary angiogram was performed, revealing a 100% occlusion at segment 6 of the coronary artery and we established a diagnosis of STEMI. The lesion was expanded to 0% stenosis through plain old balloon angioplasty, after which a third-generation drug-eluting stent was installed there. Afterwards, the patient was discharged on day 17. In this case, a combination of mild six risk factors plus family history of hypertension might lead to this atypical event.

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Cannabis and Tramadol addiction, do they imply paramount hazardous factors for acute myocardial infarction in young adults below 45 years old?

Cited by 2 publications

References 31 publications

Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review

Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review

ST-Elevation Acute Myocardial Infarction in a Young Man

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