Life events and depression

Fava, Giovanni A.; Munari, Franca; Pavan, Luigi; Kellner, Robert

doi:10.1016/0165-0327(81)90040-9

Cited by 139 publications

(34 citation statements)

References 27 publications

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“…A subdivision between patients with pituitary-dependent (Cushing's disease) and pituitaryindependent (primary adrenal hyperfunction or ectopic ACTH production) forms, compared with their matched controls, indicated a causal role for stressful life events exclusively in Cushing's disease (Sonino et al, 1993b), supporting the hypothesis of a limbic-hypothalamic involvement in the pathogenesis of this condition (Krieger, 1983). The results in Cushing's disease are remarkably similar to those obtained comparing depressed patients with the general population, and in particular to those of a study (Fava et al, 1981b) performed with the same methods, in the same geographical area. This adds to other analogies between Cushing's disease and nonendocrine major depression, and calls for further investigation on the pathogenetic mechanisms of both conditions .…”

Section: Life Eventssupporting

confidence: 77%

Psychological aspects of endocrine disease

Sonino

Fava

1998

Clinical Endocrinology

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Section: Life Eventssupporting

confidence: 77%

Psychological aspects of endocrine disease

Sonino

Fava

1998

Clinical Endocrinology

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“…Basically, the literature is fairly consistent in reporting an excess of negative (exit) events in the 6–12 months preceding depression [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18], schizophrenia [19,20,21,22,23] and anxiety disorders [24,25,26,27,28,29,30,31,32,33]. …”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Life Events: Life Events and Psychiatric Disorders in the Sesto Fiorentino Study

Faravelli

Catena

Scarpato

et al. 2007

Psychother Psychosom

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Background: Although life events have been consistently reported as precipitating factors for most psychiatric disorders, there is no comprehensive investigation of the relationship between severe life events and psychiatric disorders in the general population. Methods: This is a community-based study of psychiatric disorders among a cohort representative of adults in an Italian town. A total of 2,363 subjects out of 2,500 selected to be representative of the population living in Sesto Fiorentino, central Italy, were interviewed by their own general practitioner using the Mini International Neuropsychiatric Interview. Of the 613 subjects, 609 who resulted positive for any psychiatric disorders and 123 out of a random sample of 130 negatives were re-interviewed by the psychiatrists using the Florence Psychiatric Interview. The Florence Psychiatric Interview was used to explore each distinct psychiatric episode. Life events were recorded in detail by a specific interview. Results: During the year prior to the onset of the first psychiatric disorder, 35.8% of cases suffered from at least a severe event, compared with 12.2% of non-cases during a comparable period (OR = 4.0, 95% CI = 2.3–7.1). The excess of life events occurred for almost all the diagnostic categories. The same results were reproduced even when only the ‘independent’ life events were considered. The distribution of the events through the 12 months taken into account showed an even distribution of events among non-cases, whereas there was a clear accumulation in the last 3 months prior to the onset of the pathology in the cases. Conclusions: Life stress is one of the main precipitating factors of psychopathology.

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“…Patients with panic disorder showed a memory bias for panic-related material during active illness [33]. In life events research, a delay in the interview until the acute disturbance has passed [34]results in a less distorted history.…”

Section: Methodological Issuesmentioning

confidence: 99%

Subclinical Symptoms of Panic Disorder: New Insights into Pathophysiology and Treatment

Fava

Mangelli²

1999

Psychother Psychosom

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The aim of this review was to survey the available literature on prodromal and residual symptoms of panic disorder. Both a computerized (Medline) and a manual search of the literature were performed. In a substantial proportion of patients with panic disorder with agoraphobia a prodromal phase can be identified. Most patients report residual symptoms despite successful treatment. Residual symptoms upon remission have a prognostic value. There appears to be a relationship between residual and prodromal symptomatology (the rollback phenomenon). Appraisal of subclinical symptomatology in panic disorder has important implications as to the pathophysiological model of disease, its conceptualization and treatment.

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Life events and depression

Cited by 139 publications

References 27 publications

Psychological aspects of endocrine disease

Psychological aspects of endocrine disease

Epidemiology of Life Events: Life Events and Psychiatric Disorders in the Sesto Fiorentino Study

Subclinical Symptoms of Panic Disorder: New Insights into Pathophysiology and Treatment

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