Life Event Stress and Headache Frequency Revisited

Reynolds, David; Hovanitz, Christine A.

doi:10.1046/j.1526-4610.2000.00016.x

Cited by 27 publications

(26 citation statements)

References 30 publications

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“…Stress, a commonly recognized trigger of migraine (Passchier, 1994;Reynolds and Hovanitz, 2000), may also initiate or intensify attacks, perhaps by acting on an unstable pain control system (Lance, 1993). In particular, stimulation from higher brain centres, such as the cortex or hypothalamus during stress or emotion, or excessive afferent input from the special senses or cranial vessels, may compromise the pain control system in individuals vulnerable to migraine.…”

Section: Migraine Triggersmentioning

confidence: 99%

Migraine and motion sickness: What is the link?

Cuomo-Granston

Drummond

2010

Progress in Neurobiology

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The brainstem is a structurally complex region, containing numerous ascending and descending fibres that converge on centres that regulate bodily functions essential to life. Afferent input from the cranial tissues and the special senses is processed, in part, in brainstem nuclei. In addition, brainstem centres modulate the flow of pain messages and other forms of sensory information to higher regions of the brain, and influence the general excitability of these cortical regions. Thus, disruptions in brainstem processing might evoke a complex range of unpleasant symptoms, vegetative changes and neurovascular disturbances and that, together, form attacks of migraine. Migraine is linked with various co-morbid conditions, the most prominent being motion sickness. Symptoms such as nausea, dizziness and headache are common to motion sickness and migraine; moreover, migraine sufferers have a heightened vulnerability to motion sickness. As both maladies involve reflexes that relay in the brainstem, symptoms may share the same neural circuitry. In consequence, subclinical interictal persistence of disturbances in these brainstem pathways could not only increase vulnerability to recurrent attacks of migraine but also increase susceptibility to motion sickness. Mechanisms that mediate symptoms of motion sickness and migraine are explored in this paper. The physiology of motion sickness and migraine is discussed, and neurotransmitters that may be involved in the manifestation of symptoms are reviewed. Recent findings have shed light on the relationship between migraine and motion sickness, and provide insights into the generation of migraine attacks.

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Section: Migraine Triggersmentioning

confidence: 99%

Migraine and motion sickness: What is the link?

Cuomo-Granston

Drummond

2010

Progress in Neurobiology

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“…Both for men and women, sickness absence has been found to be a more powerful predictor of all-cause mortality than established self-reported health measures and available objective measures of specific physical illnesses and medical conditions (31), as well as a strong predictor of specific causes of death, such as cardiovascular disease, cancer, alcohol-related causes, and suicide (23), and a risk marker for future disability retirement (32). Observational studies have shown an increase in the risk of health problems after stressful events, including acute infections (2,3), headache (33), mental disorders (4,6), and asthma (5). All of these problems are common causes of sickness absence (34).…”

Section: J Vahtera Et Almentioning

confidence: 99%

Sex Differences in Health Effects of Family Death or Illness: Are Women More Vulnerable Than Men?

Vahtera¹,

Kivimäki²,

Väänänen³

et al. 2006

Psychosomatic Medicine

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“…A study by Reynolds and Hovanitz [15] found a mild correlation between the occurrence of NLEs and the frequency of headaches, which was no longer significant after adjustment for depression diagnosis. There was no separate analysis focusing on the migraine subgroup in that study.…”

Section: Introductionmentioning

confidence: 99%

Negative life events and migraine: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline data

et al. 2014

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BackgroundStress is a typical migraine trigger. However, the impact of negative life events on migraine activity is poorly studied. The aim of this study is to investigate the association between negative life events and migraine using data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment.MethodsELSA-Brasil is a multicenter cohort study conducted in six Brazilian cities. Baseline assessment included validated questionnaires for headache classification and the occurrence of five pre-specified negative life events (financial hardship, hospitalization other than for childbirth, death of a close relative, robbery and end of a love relationship), focusing on a 12-month period before evaluation. We built crude and adjusted logistic regression models to study the association between the occurrences of negative life events and migraine diagnosis and activity.ResultsWe included 4,409 individuals with migraine and 4,457 participants without headache (reference). After adjustment for age, sex, race, income and educational level, we found that the occurrence of a negative life event (Odds ratio = 1.31; 95% confidence interval = 1.19 – 1.45) was associated with migraine. However, after stratifying with subgroup analyses, only financial hardship (Odds ratio = 1.65; 95% confidence interval = 1.47 – 1.87) and hospitalization (Odds ratio = 1.47; 95% confidence interval = 1.25 – 1.72) were independently associated with migraine. Further adjustment for a current major depression episode and report of religious activity did not significantly change the results. Considering migraine frequency as (a) less than once per month, (b) once per month to once per week, or (c) more than once per week, financial hardship and hospitalization remained significantly associated with migraine in all episode frequency strata, with higher odds ratios for higher frequencies in adjusted models. We also observed a significant association between the death of a close relative and the highest migraine frequency stratum (Odds ratio = 1.38; 95% confidence interval = 1.09 – 1.75) in full-adjusted model.ConclusionsThe occurrence of financial hardship and hospitalization had a direct and independent association with migraine diagnosis and frequency. The death of a close relative was also independently associated with the highest migraine frequency stratum.

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Life Event Stress and Headache Frequency Revisited

Cited by 27 publications

References 30 publications

Migraine and motion sickness: What is the link?

Migraine and motion sickness: What is the link?

Sex Differences in Health Effects of Family Death or Illness: Are Women More Vulnerable Than Men?

Negative life events and migraine: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline data

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