Lidocaine/β-cyclodextrin inclusion complex as drug delivery system

Abou‐Okeil, A.; Rehan, Mohamed; El‐Sawy, S.M.; El-Bisi, Manal K.; Ahmed-Farid, Omar A.; Abdel‐Mohdy, F.A.

doi:10.1016/j.eurpolymj.2018.09.016

Cited by 50 publications

(27 citation statements)

References 58 publications

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“…The CCD/P and CCD/P-PhEA-PIP systems were also characterized using TGA to obtain the information on the formation of the polymers and effective inclusion of the drugs within the polymer matrix based on the changes in their thermal decomposition [ 101 , 102 ]. Figure 6 shows the thermal decomposition curves of native βCD (A), CCD/P (B), and CCD/P-PhEA-PIP (C).…”

Section: Resultsmentioning

confidence: 99%

Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

et al. 2021

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Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection.

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Section: Resultsmentioning

confidence: 99%

Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

et al. 2021

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“…For example, CDs can improve the solubility of the guest [ 28 , 29 , 30 ]. Their synthesis methods include the saturated aqueous solution method, the ultrasonic method, grinding, colloid milling, freeze drying, and spray drying [ 31 , 32 , 33 ]. There are various synthetic methods that are widely used in the field of biomedicine and their applications will be explained in detail below.…”

Section: Synthesis Of Pcdsmentioning

confidence: 99%

Research Progress on Synthesis and Application of Cyclodextrin Polymers

et al. 2021

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Cyclodextrins (CDs) are a series of cyclic oligosaccharides formed by amylose under the action of CD glucosyltransferase that is produced by Bacillus. After being modified by polymerization, substitution and grafting, high molecular weight cyclodextrin polymers (pCDs) containing multiple CD units can be obtained. pCDs retain the internal hydrophobic-external hydrophilic cavity structure characteristic of CDs, while also possessing the stability of polymer. They are a class of functional polymer materials with strong development potential and have been applied in many fields. This review introduces the research progress of pCDs, including the synthesis of pCDs and their applications in analytical separation science, materials science, and biomedicine.

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“…Interpenetrating polymer networks (IPNs) hydrogels are composed of two separate entangled polymer chains that are independently cross‐linked without a formation of any covalent bonds between them 20,21 . The IPNs are responsive not only for the chemical architecture of the macromolecular matrices, but also for the surrounding conditions such as pH, ionic strength, temperature, magnetic field, etc.…”

Section: Introductionmentioning

confidence: 99%

“…As fact that SA can effectively frame gel by cross‐linking with multivalent cations, its mechanical properties are unsatisfactory at damp state, which is restricted to their applications. To make strides in mechanical properties, combinations of alginates and other polymers, for example, poly(vinyl liquor), gelatin, and chitosan, …etc., not only to improve the mechanical properties but also to enhance the drug release profile 20,36‐38 and sometimes cyclodextrins, which are used as host molecules in some drug and many other components 39 …”

Section: Introductionmentioning

confidence: 99%

К‐carrageenan/Na‐alginate wound dressing with sustainable drug delivery properties

Fahmy¹,

Aly²,

Sayed³

et al. 2021

Polymers for Advanced Techs

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Despite К‐carrageenan (КC) merits as a biopolymer convenient for versatile medical applications, it exhibits limitations in processability and reactivity. To overcome such limitations, КC, in this study, was blended with Na‐alginate (SA) in different weight ratios and cross‐linked with potassium ions. The swelling and gel fraction properties demonstrate that the cross‐linked КC/SA matrix of a ratio of 66.7% is suitable to be applied as a topical wound dressing. Characterization of the prepared КC/SA/K+ gel film was performed using scanning electron microscope as well as FTIR. The in vitro release of chloramphenicol as a drug model from the nominated loaded film at pH 4.1 reached a constant value after about 3 hours. To enhance the antibacterial properties of the КC/SA/K+ film, silver nanoparticles as bioactive additive were loaded in combination with chloramphenicol, and the antibacterial properties of the loaded film were evaluated, and showed high antibacterial properties against both Gram‐positive and Gram‐negative bacteria.

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Lidocaine/β-cyclodextrin inclusion complex as drug delivery system

Cited by 50 publications

References 58 publications

Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

Research Progress on Synthesis and Application of Cyclodextrin Polymers

К‐carrageenan/Na‐alginate wound dressing with sustainable drug delivery properties

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