Lichtdiagnostische Verfahren bei Patienten mit Verdacht auf Photodermatosen

Lehmann, P.; Hölzle, Erhard; Kries, Rüdiger von; Plewig, Gerd

doi:10.1007/978-3-642-72828-0_8

Cited by 18 publications

(32 citation statements)

References 74 publications

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“…21,22 The development of positive reactions of phototests in LE is considerably slower and persists longer than in other photodermatoses such as PLE. 21,22,25 In contrast to previous observations, most of the patients with LET reacted to UV-A and UV-B irradiation, as found for other forms of cutaneous LE.…”

Section: Phototestingmentioning

confidence: 99%

“…Minimal erythema dose (MED), threshold dose for immediate pigment darkening (IPD), and minimal tanning dose (MTD) were determined as previously described. 21,22 For the provocative phototesting, areas (4ϫ5 cm) of uninvolved skin on the upper back were irradiated with single doses of 100 J/cm 2 UV-A and/or 1.5 MED UV-B, respectively, daily for 3 consecutive days. Test areas were evaluated until specific lesions appeared for up to 4 weeks after the last irradiation.…”

Section: Phototestingmentioning

confidence: 99%

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Lupus Erythematosus Tumidus

Kuhn¹,

Richter-Hintz²,

Oslislo³

et al. 2000

Arch Dermatol

213

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Section: Phototestingmentioning

confidence: 99%

Section: Phototestingmentioning

confidence: 99%

Lupus Erythematosus Tumidus

Kuhn¹,

Richter-Hintz²,

Oslislo³

et al. 2000

Arch Dermatol

213

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“…The previous results of photoprovocation studies in CLE patients were variable and ranged from 24 -83% positivity (17,31,32). These discrepancies may largely be explained by the variability of photoprovocation protocols and the differences in the types of CLE patients.…”

Section: Discussionmentioning

confidence: 97%

“…(17,24). Areas (4 ϫ 5 cm) of uninvolved skin on the upper back, extensor aspects of the arms, shoulders, thighs, or buttocks were irradiated with single doses of UVA (60 -100 J/cm 2 ), UVB (1.5 MED), and UVA and UVB daily for 3 consecutive days for photoprovocation ( Figures 1A and B).…”

Section: Significance and Innovationsmentioning

confidence: 99%

“…In further applications, other investigators used monochromatic light to determine the wavelength by applying the repeated UV exposure technique (15,16). A standardized photoprovocation protocol based on the discovery that the action spectrum of CLE reaches into the long-wave UVA region was developed by Lehmann and coworkers (17) in 1986. A subsequent study demonstrated that CLE can be induced by experimental UVA or UVB irradiation in 43% of patients (18).…”

Section: Introductionmentioning

confidence: 99%

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Updated Analysis of Standardized Photoprovocation in Patients With Cutaneous Lupus Erythematosus

Ruland

Haust

Stilling

et al. 2013

Arthritis Care & Research

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Objective. To determine the frequency and reproducibility of standardized photoprovocation in patients with cutaneous lupus erythematosus (CLE) and report our long-term experience. Methods. Photoprovocation using a standardized protocol was evaluated retrospectively in 566 patients. A diagnosis of CLE was clinically and/or histologically confirmed in 431 patients, and 315 patients with polymorphic light eruption (PLE) were additionally included as controls. Data were statistically analyzed using an SPSS database. Results. A total of 61.7% of the 431 CLE patients exhibited a positive photoprovocation, with a significantly longer latency period for the development of skin lesions after ultraviolet (UV) A and/or UVB irradiation than PLE patients (P < 0.001). The frequency of positive photoprovocation varied among the CLE subtypes, and intermittent CLE was the most photosensitive disease entity (74.8%). Subsequent photoprovocation in 35 patients demonstrated that CLE patients with an initial positive result exhibited a significantly higher frequency of a positive photoprovocation at a later time point (P ‫؍‬ 0.013). However, an initial positive photoprovocation did not definitively predict a positive reaction at a later time point. Moreover, patient history of photosensitivity was not a predictor for the photoprovocation outcome. Conclusion. Standardized photoprovocation is a useful tool to reproducibly induce skin lesions and objectively evaluate photosensitivity in patients with CLE. These data further suggest that the reaction to UV light may change during the course of this heterogeneous disease and that photosensitivity should not be excluded in patients with a negative history of photosensitivity.

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Indikation, Durchführung und Aussagekraft des Photopatchtests

Przybilla¹

1987

Fortschritte Der Praktischen Dermatologie Und Venerologie

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Lichtdiagnostische Verfahren bei Patienten mit Verdacht auf Photodermatosen

Cited by 18 publications

References 74 publications

Lupus Erythematosus Tumidus

Lupus Erythematosus Tumidus

Updated Analysis of Standardized Photoprovocation in Patients With Cutaneous Lupus Erythematosus

Indikation, Durchführung und Aussagekraft des Photopatchtests

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