Licht- und elektronenmikroskopische Beobachtungen �ber die Einwirkung von Argonlaserstrahlen auf das Pigmentepithel der anliegenden menschlichen Retina

Lerche, W.

doi:10.1007/bf00531119

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…Retinal oedema was previously found in 0 to 2-4 h old lesions which involved the pigment epithelium and photoreceptor cells (1,appin C Coogan 1970;Lerche 1973;Adams et al 1973), whereas there was no evidence of oedema in photoreceptor cell lesions with intact pigment epithelium (Kuwabara k Gorn 1968; Burger k Klintworth 1974). T h e retinal oedeina found in the present study the first day after irradiation was limited to the damaged avascular layers of the retina.…”

Section: The Retinal Oedemamentioning

confidence: 93%

The Process of Wound Healing of the Avascular Outer Layers of the Retina

Bülow

1978

Acta Ophthalmologica

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The process of wound healing of the avascular outer layers of the retina is studied on a series of Laser lcsions of the monkey, Ccrc.oliitl/fr.ilt;~~~~.~ uelhio/).s. T h e extent of the retinal lesions is limited to thc pigment epithelium and photoreceptor cells, whereas Bruch's membrane anti the vascular inner layers of the retina remain intact. The retinal lesions arc not seen to be invaded by cells from the chortiid. nor from the retinal vessels. During the first three days after irradiation the pigment epithelial cells in a zone, about 7 5 pin wide. around the lesions appear to be changcd into bi-or multinucleate cells with thc additional nuclei situated in apical cytoplasmic protrusions which extend towards and into the lesions. During the second and third days after irradiation the lesions arc invaded by two kinds of cells which both appear to arise through the off-budding of the nucleus-containing apical protrusions of the pigment epithelial cells around the lesions: (a) phagocytic cells which disintegrate the damaged tissue and, as this process is completed 4-9 days after irradiation show cvitlence of melanogcncsis; and (b) regenerated pigment epithelium which forin a single lnycr of rells along Bruch's membrane, but show no evidc nce of phagocytosis or intracellular disintegration of the damaged tissue. Within the lesions both these kinds of cells show mitotic figures the third clay after irratliation.

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Section: The Retinal Oedemamentioning

confidence: 93%

The Process of Wound Healing of the Avascular Outer Layers of the Retina

Bülow

1978

Acta Ophthalmologica

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“…Im Bereich des hinte ren Pols enthält diese Membran normaler weise keine Zellen H ogan und A lvarado, 1967;Lerche, 1972a;Spitznas, 1974], Nur bei pathologischen Ver änderungen nach Kryokoagulation oder La serstrahleinwirkung sind solche nachweisbar [Lerche, 1972b[Lerche, , 1973 …”

Section: Diskussionunclassified

Elektronenmikroskopische Untersuchungen über den Aufbau des Pigmentepithels an der Ora serrata

Lerche¹,

Kaune²

1980

Ophthalmologica

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The structure of the pigment epithelium at the ora serrata is examined in 10 human eyes aged from 31 to 90 years. The cells of the pigment epithelium show a different construction depending on their position relative to the ora. Directly at the ora serrata, in the cohesion band, the cells are higher and contain more pigment granula than those which are situated in a central region. In this sector we sometimes find overlapping of cells, which feigns two layers of epithelium. There are clearly fewer basal folding ins of the pigment epithelial cells at the ora than in the other parts of the retina. At the ora serrata pathological changes start in the 3rd decade of life. They include swelling and later on more or less pronounced cystoid degeneration of the epithelial cells. Within Bruch’s membrane two kinds of cells are seen. In the ora gap six types of free cells can be distinguished, whose origin is discussed especially. Probably they originate from the chorioidea, the pigment epithelium and the sensory retina.

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“…In addition a peculiar marginal fluorescence in fluorescein serial angiograms of old light coagulation foci is described and compared with data from the literature. Aber auch bei den verschiedensten Augenhin-tergrundserkrankungen, wie Makuladegeneration (10,11,15,24,37,50,57), Toxoplasmose (32), Aderhauttumoren (51), Angioid streaks (24,17), stumpfen Bulbustraumen (24,39), perforierenden Bulbusverletzungen (35), Chorioiditis 21…”

mentioning

confidence: 99%

“…(17) fanden eberifalls 4 Wochen nach experimenteller intensiver Laserkoagulation am Rande der Effekte Proliferationen von Kapillaren aus der Aderhaut. Erklãren 1äft sich dieses Phänomen durch die lokalen morphologischen und zellulären Ver-anderungen nach Fotokoagulation(35,54,55).Gloor (22) beschreibt die Transposition von depigmentierten Pigmentepitheizellen insbesondere in den Randzonen dieser Fotokoagulationseffekte.…”

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Was vermag die Fotokoagulation und was bewirkt sie?

Deufrains¹,

Dietze²,

Jütte³

1980

Klin Monatsbl Augenheilkd

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Six hypotheses relating to the mode of action of photocoagulation, based on comprehensive data gathered from the literature, are put forward and discussed. Particular emphasis is given to the question of achieving a lasting break through of the barrier represented by Bruch's membrane and the pigment epithelium and thus to the altered diffusion conditions between the choriocapillaries and the retina. In addition a peculiar marginal fluorescence in fluorescein serial angiograms of old light coagulation foci is described and compared with data from the literature. The authors put forward a new hypothesis concerning the mode of action of light coagulation; they believe that particularly in the marginal areas affected by photocoagulation, completely new conditions are created for the metabolic exchange between choroid and retina, including the formation of anastomoses and shunts.

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Licht- und elektronenmikroskopische Beobachtungen �ber die Einwirkung von Argonlaserstrahlen auf das Pigmentepithel der anliegenden menschlichen Retina

Cited by 8 publications

References 10 publications

The Process of Wound Healing of the Avascular Outer Layers of the Retina

The Process of Wound Healing of the Avascular Outer Layers of the Retina

Elektronenmikroskopische Untersuchungen über den Aufbau des Pigmentepithels an der Ora serrata

Was vermag die Fotokoagulation und was bewirkt sie?

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