Lichens: Might Be Considered as a Source of Gastroprotective Molecules?

Sepúlveda, Beatriz; Chamy, Marı́a C.; Piovano, Marisa; Areche, Carlos

doi:10.4067/s0717-97072013000200024

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…Buzgar et al [532] investigated fragments of a wall painting in Graeco-Roman contexts from the Beroe fortress, Romania (4-6th century), and identified a yellow-brown pigment as K-jarosite KFe 3+ 3 (OH) 6 (SO 4 ) 2 and/or Na-jarosite. Sepúlveda et al [533] studied yellow blocks from the archaeological site Playa Miller 7, on the coast of Atacama Desert in northern Chile, and reported the use of K-jarosite and natrojarosite in prehispanic times (approximately 2500 years BP). Pelosi et al, [534] using micro-Raman analysis, revealed the presence of jarosite in wall paintings in Cappadocia (Turkey).…”

Section: Yellow Pigmentsmentioning

confidence: 99%

Raman spectroscopy of minerals and mineral pigments in archaeometry

Bersani

Lottici

2016

J Raman Spectroscopy

144

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Minerals, as raw structural materials or pigments, play a fundamental role in archaeometry, for the understanding of nature, structure and status of an artefact or object of interest for cultural heritage. A detailed knowledge of the mineral phases is crucial to solve archaeological problems: Raman spectroscopy is a powerful investigation technique and has been applied extensively in the last 30 years on mineral identification and on pigment degradation. Here we report an updated review, covering the last decade, of the applications of Raman techniques to issues in which raw minerals, including mineral pigments, are involved. Particular attention is devoted to cases where the Raman analysis of minerals is deeper than a simple identification of the phases present in an archaeological or artistic object. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Yellow Pigmentsmentioning

confidence: 99%

Raman spectroscopy of minerals and mineral pigments in archaeometry

Bersani

Lottici

2016

J Raman Spectroscopy

144

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“…2011), gastroprotective (Sepulveda et al . 2013) and analgesic (Bugni et al . 2009) properties as well as wound healing (Barreto et al .…”

Section: Introductionmentioning

confidence: 99%

“…Less frequently, atranorin has been noted as a herbivore deterrent (Pöykkö et al 2005;Nimis & Skert 2006), an inhibitor of competitive species (Whiton & Lawrey 1984) and a reducing agent to facilitate iron and phosphate uptake in acidic soils (Paul et al 2009). Atranorin also has many potential human health applications, including anticancer (Bačkorová et al 2012), antimicrobial (Türk et al 2006;Kosanić et al 2013), prooxidant and antioxidant (Melo et al 2011), gastroprotective (Sepulveda et al 2013) and analgesic (Bugni et al 2009) properties as well as wound healing (Barreto et al 2013), biofilm inhibition (Pompilio et al 2013) and mosquito abatement as a larvicide (Cetin et al 2012).…”

Section: Introductionmentioning

confidence: 99%

The optimal extraction and stability of atranorin from lichens, in relation to solvent and pH

et al. 2018

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Atranorin is a secondary metabolite found in many lichens. This compound can act as a photo-buffer, supporting its use as a marker of metabolic response to changes in light. In preliminary trials, atranorin was found to be unstable over time when in solution, potentially precluding its usefulness in this capacity. The present study tests the stability of atranorin in different extraction solvents and at different pH values over time using HPLC analysis. We found that atranorin is most stable in acetonitrile, among six tested solvents, and that the presence of strong acid or a strong base destabilizes the compound. We propose that atranorin breaks down through transesterification in methanol and ethanol until an equilibrium is reached, while a strong base breaks down atranorin through saponification and under acidic conditions, atranorin concentration significantly increases with time. Although atranorin levels were found to be stable in whole thallus extracts from fresh lichens using a leaching method, chemicals isolated using chromatographic separation showed similar breakdown to an atranorin standard. In future work on lichens atranorin should be extracted in acetonitrile or acetone without an added base or acid to yield the greatest stability and thus provide more accurate concentration values of atranorin with time using HPLC. The interactions of atranorin with acid and with chloroform need further study.

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“…Thus, cardiovascular protective activity of PSA detected presence of the antioxidant capacity was also included in the results of the same study. Another study on the protective effect of PSA was carried out on mice and the gastric protective effect of PSA was determined (Sepulveda et al 2013). In the studies related with toxic concentrations of PSA, inhibition of growth as determined in different bacteria species (Celenza et al 2013;Mitrović et al 2014), liver parasites (Lauinger et al 2013) and some cancer cells (Correcché et al 2004;Brandao et al 2013) exposed to PSA.…”

Section: Discussionmentioning

confidence: 99%

In vitroantitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells

Emsen

Aslan

Toğar

et al. 2015

Pharmaceutical Biology

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Context Since methods utilised in the treatment of glioblastoma multiforme (GBM) are inadequate and have too many side effects, usage of herbal products in the treatment process comes into prominence. Lichens are symbiotic organisms used for medicinal purposes for many years. There are various anticancer treatments about components of two lichen species used in the present study. Objective Antitumor potential of three lichen secondary metabolites including olivetoric acid (OLA) and physodic acid (PHA) isolated from Pseudevernia furfuracea (L.) Zopf (Parmeliaceae) and psoromic acid (PSA) isolated from Rhizoplaca melanophthalma (DC.) Leuckert (Lecanoraceae) were investigated on human U87MG-GBM cell lines and primary rat cerebral cortex (PRCC) cells for the first time. Materials and methods PRCC cells used as healthy brain cells were obtained from SpragueDawley rats. The treatments were carried out on the cells cultured for 48 h. Cytotoxic effects of different concentrations (2.5, 5, 10, 20 and 40 mg/L) of metabolites on the cells were determined via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) analyses. Total antioxidant capacity (TAC) and total oxidant status (TOS) parameters were used for assessing oxidative alterations. Oxidative DNA damage potentials of metabolites were investigated via evaluating 8-hydroxy-2 0 -deoxyguanosine (8-OH-dG) levels. Results Median inhibitory concentration (IC 50 ) values of OLA, PHA and PSA were 125.71, 698.19 and 79.40 mg/L for PRCC cells and 17.55, 410.72 and 56.22 mg/L for U87MG cells, respectively. It was revealed that cytotoxic effects of these metabolites showed positive correlation with concentration, LDH activity and oxidative DNA damage. Discussion and conclusion The present findings obtained in this study revealed that primarily OLA and then PSA had high potential for use in the treatment of GBM. ARTICLE HISTORY

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Lichens: Might Be Considered as a Source of Gastroprotective Molecules?

Cited by 10 publications

References 14 publications

Raman spectroscopy of minerals and mineral pigments in archaeometry

Raman spectroscopy of minerals and mineral pigments in archaeometry

The optimal extraction and stability of atranorin from lichens, in relation to solvent and pH

In vitroantitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells

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