Lichen planus pemphigoides: its relationship to bullous pemphigoid

Davis, A L; Bhogal, B.; Whitehead, Philip; Frith, Peggy; Murdoch, Michele E.; Leigh, Irene M.; Wojnarowska, Fenella

doi:10.1111/j.1365-2133.1991.tb14753.x

Cited by 89 publications

(53 citation statements)

References 32 publications

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“…Here, band-like deposits of C3 along the basal membrane and of immunoglobulins along the junction zone can be observed in lichen planus pemphigoides. Almost always the autoantibodies are targeted against the NC16A-domain of the hemidesmosomal protein BP180 [46,68].…”

Section: Histopathologymentioning

confidence: 99%

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Clinical variants of lichen planus

Wagner

Rosé²,

Sachse

2013

J Deutsche Derma Gesell

100

132

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SummaryLichen planus is characterized by lichenoid, polygonal papules with fine white lines, called Wickham striae. Lesions most commonly occur on the limbs and on the dorsal aspect of the trunk. At the same time often leukoplakia of mucous membranes as well as nail disorders are seen.There are numerous variants of lichen planus which can be distinguished from the classical form on the basis of morphology and distribution of the lesions. The typical primary lesion of lichen planus may be replaced by other forms, such as patches, hyperkeratoses, ulcerations, or bullous lesions. Moreover, distribution patterns of these lesions may vary and include erythrodermic, inverse or linear arrangements. In contrast to these numerous clinical features, histologic findings remain characteristic in the variants, so that the diagnosis can be made securely. Differential diagnoses of lichen planus include diverse dermatoses such as bullous pemphigoid or paronychia.

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Section: Histopathologymentioning

confidence: 99%

“…Clinical features, histopathology and immunofl uorescence of lichen planus pemphigoides display fi ndings of LP as well as bullous pemphigoid [46]. In lichen planus pemphigoides the blisters develop not only on pre-existing LP lesions as is typical for bullous lichen planus, but also on unaltered skin [47].…”

Section: Lichen Planus Pemphigoidesmentioning

confidence: 99%

Clinical variants of lichen planus

Wagner

Rosé²,

Sachse

2013

J Deutsche Derma Gesell

100

132

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“…LPP may be treated with topical steroids, systemic steroids , tetracycline & nicotinamide, isotretinoin, dapsone with immunosuppressive drugs with variable success 5,7,9,10,11 .…”

Section: Discussionmentioning

confidence: 99%

Lichen Planus Pemphigoides: A Case Report

Bhuiyan

Hossain

Khan

et al. 2012

J Shaheed Suhrawardy Med Coll

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Lichen planus pemphigoides describe a rare subset of patients who usually have typical lichen planus then develop blistering on their lichen planus lesions and in normal skin. Less commonly the blistering antedates the lichen planus. They clinically appear to be a combination of lichen planus and bullous pemphigoid. Oral disease may occur and resemble either lichen planus or bullous pemphigoid. Lichen planus pemphigoides has been triggered by medication & PUVA. Pruritus may be severe and lesions may evolve to resemble pemphigoid nodularis. Histopathologically lichen planus lesions show lichen planus and bullous lesion shows the features of bullous pemphigoid. DIF is positive in a linear pattern with IgG and C3 along the basement membrane zone, at the roof of saline split skin. The antigen targeted by the autoantibody in Lichen planus pemphigoides is located in the same region as the bullous pemphigoid antigen (at the basal hemidesmosomes). Lichen planus pemphigoides tends to follow a benign and chronic course, even when compared to bullous pemphigoid. We diagnosed a case of Lichen planus pemphigoides on the basis of history, clinical examination, histopathology & DIF. The patient was treated with systemic & topical steroid, Dapsone. After 2 month of treatment steroid was withdrawn, but Dapsone continue with no relapse.To our knowledge this is the first diagnosed and treated case in this hospital.

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“…Im Gegensatz zum klassischen Lichen ruber findet sich in der direkten Immunfluoreszenz beim Lichen ruber pemphigoides stets eine bandförmige Ablagerung von Komplement C3 entlang der Basalmembran, meist auch die von Immunglobulinen (häufig IgG) entlang der Junktionszone [6]. Bei 40 ± 50 % der Patienten sind auch zirkulierende Antikörper gegen die Basalmembranzone nachweisbar.…”

Section: Introductionunclassified

Lichen ruber pemphigoides

2004

Akt Dermatol

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A 56-year-old female patient suffered from multiple pruritic papules on her dorsal legs. Within a few weeks, she additionally developed blisters on her extremities and the trunk. Histology of a papule revealed typical features of lichen planus with hyperparakeratosis, necrotic basal keratinocytes and a dense lymphocytic infiltrate. Another biopsy of a skin lesion with blister showed subepidermal dissociation and multiple neutrophil and eosinophil granulocytes. Direct immunofluorescence displayed linear deposition of complement C3 at the basal membrane. Circulating antibodies were not detected. From the clinical appearance and the histological findings including immunofluorescence results we diagnosed lichen planus pemphigoides. This rare variant of lichen planus shows features of both lichen planus and bullous pemphigoid. However, recent molecular biological investigations suggested that in patients with lichen planus pemphigoides autoantibodies with reactivity against BP180 and a 200 kDa autoantigen are responsible for disease development. Why, however, in some patients no circulating autoantibodies can be detected will have to be investigated.

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Lichen planus pemphigoides: its relationship to bullous pemphigoid

Cited by 89 publications

References 32 publications

Clinical variants of lichen planus

Clinical variants of lichen planus

Lichen Planus Pemphigoides: A Case Report

Lichen ruber pemphigoides

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