Lichen planus pemphigoides: Entity or Association?

Souteyrand, P.; Pierini, Adrián Martín; Fernández-Bussy, Ramón; Thivolet, J; Cambazard, F.

doi:10.1159/000250309

Cited by 26 publications

(6 citation statements)

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“…As reported in the liter ature [14,15,18,19], our patient developed bullous lesions on both lichenoid papules and normal skin; the histological study showed a subcpidcrmal bulla and a dermal lichenoid infiltrate, and direct immuno fluorescence revealed both colloid bodies and a linear continuous deposit of IgG and C3 at the BMZ. The absence of circulating antibodies has been previously noted [20].…”

Section: Discussionmentioning

confidence: 77%

Captopril-Induced Lichen planus pemphigoides with Pemphigus-Like Features

et al. 1986

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We report a case of a bullous lichenoid eruption due to the intake of captopril. Clinical, histological, direct immunofluorescence and ultrastructural features were consistent with the diagnosis of lichen planus pemphigoides. In addition, the in vivo immunological study also revealed an intercellular fluorescence, similar to that seen in pemphigus. Complex drug-induced cutaneous reactions have been previously reported with other drugs, especially with D-penicillamine, which bears chemical similarities with captopril. However, such a drug-induced mixed pattern of lichen planus pemphigoides with pemphigus-like features has never been reported.

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Section: Discussionmentioning

confidence: 77%

Captopril-Induced Lichen planus pemphigoides with Pemphigus-Like Features

et al. 1986

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“…In comparison with classical BP, the onset of the disease in LPP is seen in younger patients (the mean age of recent cases in the literature is 43 years), the course of LPP is less severe, the distribution of the blisters is preferentially on the distal extremities, and antibasement membrane (BMZ) circulating antibodies are detectable in only 50% of patients with LPP. 15 Moreover, the involved target antigen corresponds to classical BP antigens in only four of the 10 cases reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Lichen planus pemphigoides is a heterogeneous disease: a report of five cases studied by immunoelectron microscopy

et al. 1998

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Lichen planus pemphigoides (LPP) is a rare and controversial disease. It is characterized by bullae arising on lichen planus papules and on uninvolved skin, subepidermal bullae in histology, and linear deposits of IgG and C3 along the basal membrane zone on immunofluorescence of peribullous skin. Our goal was to identify the localization of the target antigen in cases of LPP. Five patients diagnosed with LPP on clinical, histological and immunofluorescence criteria were explored by immunoelectron microscopy and immunoblot. Our results show that the target antigen in LPP is not unique. The localization of the immune deposits was consistent with a diagnosis of bullous pemphigoid in two cases, of cicatricial pemphigoid in two cases and of epidermolysis bullosa acquisita in one case. Our study supports the view that LPP is a heterogeneous condition in which lichen planus may induce different subepidermal acquired bullous dermatoses.

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“…This explanation, however, fails to account for the occurrence of bullae on normal skin in LPP. Microscopic investigations of LPP show the concommitant occurrence of typical LP-Iesions and the histological and direct immunofluorescence findings characteristic of bullous pemphigoid (BP) (StingI & Holubar, 1975;Sobel, Miller & Shatin, 1976;Saurat et al, 1977;Morel, Sauret & Civatte, 1978;Mora, Nesbitt & Brantley., 1983), with circulating antibodies in only 50 per cent of the cases (Souteyrand et al, 1981).…”

Section: Discussionmentioning

confidence: 96%