Lichen planus of the nail matrix with predominant plasma cell infiltrate

Hall, Rebecca R.; Wartman, David G.; Jellinek, Nathaniel J.; Robinson‐Bostom, Leslie; Telang, Gladys H.

doi:10.1111/j.1600-0560.2007.00965.x

Cited by 13 publications

(13 citation statements)

References 10 publications

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“…Epithelial hyperkeratosis was observed in 66% of our patients, being more predominant in the reticular form. This increased thickness of the corneal layer has also been described in several other studies (15,16). As regards acanthosis, our data is consistent with that found in the literature (15,16), with percentages of approximately 48%.…”

Section: Discussionsupporting

confidence: 83%

“…This increased thickness of the corneal layer has also been described in several other studies (15,16). As regards acanthosis, our data is consistent with that found in the literature (15,16), with percentages of approximately 48%. The presence of serrated ridges is another one of the histological findings of oral lichen planus observed in 30% of our sample and described by other authors (15).…”

Section: Discussionsupporting

confidence: 83%

“…In all of the cases, it corresponds with the atrophic and erosive forms-no cases being observed in the reticular form. The presence of eosinophilic cells has been previously reported in the literature by authors such as Hall et al (16). As for the subepithelial connective tissue, we observed the presence of band-like T lymphocytes and plasma cells, a finding that is consistent with previous studies (16).…”

Section: Discussionsupporting

confidence: 82%

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Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Fernández-González

R²,

Reboiras-López³

et al. 2011

Med Oral

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Objectives: To highlight the most characteristic histopathological findings of oral lichen planus and their correlation with the clinical manifestations and forms. Study design: We performed a retrospective study of 50 biopsied and diagnosed cases of oral lichen planus obtained over a period of 11 years, spanning from May 1998 to April 2009. We analyzed the age and sex of the patient, type of lichen planus, location and different histopathological findings, comparing them with the clinical lesions. Results: Seventy eight percent of the patients are female and 22% are male, with an average age of 56.06 years for both sexes. The most frequent clinical form is reticular, present in 78% of the cases, and the most common location is the buccal mucosa, present in 70% of the patients. Hydropic degeneration of the basal layer and lymphocytic infiltration in the subepithelial layer are observed in the entire sample. Signs of atypia were identified in 4% of the cases, but without dysplasic features. Other common histological findings were the presence of necrotic keratinocytes (92%), hyperplasia (54%), hyperkeratosis (66%), acanthosis (48%), and less frequently, serrated ridges (30%) and the presence plasma cells (26%). Conclusions: Oral lichen planus is a disease that is more common in women, usually appearing in the fifth and sixth decades of life. The most common clinical form is reticular, manifesting mainly in the buccal mucosa. Histological findings characteristic of oral lichen planus include hydropic degeneration of the basal layer, lymphocytic infiltration in the subepithelial layer and the absence of epithelial dysplasia; however, it is also frequent to observe hyperplasia phenomena at the epithelial level, hyperkeratosis, acanthosis and the presence of necrotic keratinocytes.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Fernández-González

R²,

Reboiras-López³

et al. 2011

Med Oral

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“…Lichen planus has an unknown etiology, but it seems that it is an immunological process with a delayed hypersensitivity reaction, in microscopic views (3). Due to having symptoms of irritation and pain, especially in erosive and atrophic form, and the risk of malignancy, the treatment of these lesions is of the utmost importance (2).…”

Section: Introductionmentioning

confidence: 99%

“…Lichen planus is a chronic inflammatory immunological disease (1) that typically can involve the skin, mucous membranes, and nails (2). Lichen planus has an unknown etiology, but it seems that it is an immunological process with a delayed hypersensitivity reaction, in microscopic views (3).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Glycyrrhiza glabra Inorabase With Triamcinolone Acetonide Orabase in the Treatment of Oral Lichen Planus

Najafi

Beytolahi²,

Aleboye³

et al. 2016

Avicenna J Dent Res

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Background: Lichen planus is a chronic inflammatory mucocutaneous disease that is most commonly found in middle-aged women. A wide spectrum of topical and systemic therapies have been applied for treatment of this condition. Objectives: The aim of this study was to compare the efficacy and safety of 1% Glycyrrhiza glabra in orabase with 0.1% Triamcinolone Acetonide paste in treating oral lichen planus (OLP). Patients and Methods: In this study, 22 patients were randomly assigned to one of two equal groups. They received either Glycyrrhiza glabra or Triamcinolone Acetonide four times daily for a total of one month and were followed-up for three months. The patients were assessed for painful symptoms, measured by the visual analogue scale (VAS), and lesion size via Thongaprassom. The analysis and comparison of pain scores and the size of the lesions' clinical and symptomatic response rates between the two groups were performed using the Mann-Whitney U-test and SPSS 13.0 computer software. Results: Ten patients in the Glycyrrhiza glabra group and 12 patients in the triamcinolone acetonid group completed the four-month trial course. Both Glycyrrhiza glabra and Triamcinolone Acetonid reduced burning symptoms. Clinical scores in both groups also significantly improved over the one-month treatment period. The difference between the two groups was not statistically significant (P = 0.442). Conclusions: This study showed that topical Glycyrrhiza glabra appeared to be a promising alternative in the treatment of OLP. Further studies should be conducted to assess the long-term effects of Glycyrrhiza glabra.

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The Nail in Dermatological Disease

Holzberg

Baran

2012

Baran &Amp; Dawber's Diseases of the Nails and Their Management

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Lichen planus of the nail matrix with predominant plasma cell infiltrate

Cited by 13 publications

References 10 publications

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Comparison of Glycyrrhiza glabra Inorabase With Triamcinolone Acetonide Orabase in the Treatment of Oral Lichen Planus

The Nail in Dermatological Disease

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