Lichen planus and Virus C Hepatitis: Disappearance of the Lichen under Interferon Alfa Therapy

Doutre, M.-S.; Beylot, C; Couzigou, Patrice; Long, Perrin H.; Royer, Pierre‐Joseph; Beylot, J

doi:10.1159/000247552

Cited by 84 publications

(38 citation statements)

References 2 publications

(2 reference statements)

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“…A relationship between LP and liver disorders, such as primary biliary cirrhosis, viral hepatitis B and alcoholic cir rhosis has been stressed [10], and more recently a link between LP and hepatitis C virus has been reported [11][12][13], Our case represents an unusual combination of several possibly autoimmune disorders and best exemplifies the known tendency of such diseases to cluster in the same patient. The family history of vitiligo and AA suggests a genetic predisposition, and hepatitis C virus infection may have had a triggering role at least for LP.…”

Section: Discussionmentioning

confidence: 70%

Pityriasis rubra pilaris. Lichen planus, Alopecia universalis and Vitiligo in a Patient with Chronic Viral Hepatitis C

Cecchi¹,

Giomi²,

Tuci³

et al. 1994

Dermatology

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Section: Discussionmentioning

confidence: 70%

Pityriasis rubra pilaris. Lichen planus, Alopecia universalis and Vitiligo in a Patient with Chronic Viral Hepatitis C

Cecchi¹,

Giomi²,

Tuci³

et al. 1994

Dermatology

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“…On the contrary, LP exacerbations (Manns et al, 1991) and remissions have been described in patients with LP and HCV under interferon alpha therapy, and the association of LP with HCV has not infrequently been found in patients receiving alpha interferon (Cottoni et al, 1991;Mokni et at., 1991;D'Agay-Abensour et al, 1992;Divano et al, 1992;Protzer et al, 1993;Sassigneux et al, 1993;Strumia et al, 1993;Miralles et al, 1994;Papini et al, 1994). On the other hand, interferon has sometimes improved LP (Doutre et al, 1992;Frider et al, 1995). Treatment of hepatitis C may also improve OLP (Nagao et al, 1995b (Boyd and Neldner, 1991) (Table 7).…”

Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

458

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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“…It re mains to be determined whether HCV repli cates inside the involved skin and mucosal lesions. At least one report suggested a saluta ry role for alpha interferon in the treatment of HCV-associated lichen planus [46],…”

Section: Lichen Planusmentioning

confidence: 99%

Extrahepatic Manifestations of Hepatitis C

Gordon¹

1996

Dig Dis

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Shortly after the discovery of the hepatitis C virus, it was realized that this infectious agent caused more than just liver disease. A remarkable array of extrahepatic manifestations of hepatitis C has now been described. Many of these associated syndromes implicate the hepatitis C virus as a mediator of autoimmunity or of immune complex formation. These disorders include mixed essential cryoglobulinemia, autoimmune hepatitis, glomerulonephritis, thyroiditis, and possibly Sjö-gren’s syndrome. The hepatitis C virus has also been strongly linked to two skin disorders: prophyria cutanea tarda and lichen planus. Other possible hepatitis-C-associated diseases described in the literature include idiopathic pulmonary fibrosis, IgA deficiency, Mooren’s corneal ulcers, Behçet’s syndrome, polyarthritis, Guillain-Barré syndrome, idiopathic thrombocytopenic purpura, and others. A number of these reported diseases have either responded to or been cured by a therapeutic course of alpha interferon. This report discusses the reported extrahepatic manifestations of hepatitis C as of mid-1995.

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Lichen planus and Virus C Hepatitis: Disappearance of the Lichen under Interferon Alfa Therapy

Cited by 84 publications

References 2 publications

Pityriasis rubra pilaris. Lichen planus, Alopecia universalis and Vitiligo in a Patient with Chronic Viral Hepatitis C

Pityriasis rubra pilaris. Lichen planus, Alopecia universalis and Vitiligo in a Patient with Chronic Viral Hepatitis C

Update On Oral Lichen Planus: Etiopathogenesis and Management

Extrahepatic Manifestations of Hepatitis C

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