Lichen planus

Lehman, Julia S.; and, Megha M. Tollefson Md; Gibson, Lawrence E.

doi:10.1111/j.1365-4632.2009.04062.x

Cited by 183 publications

(242 citation statements)

References 128 publications

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“…The frequency is estimated at between 0.5 and 1.0 % [1,2,5,6]. In epidemiologic studies on selected patient or population groups (Table 1) prevalence rates between 0.07 and 0.84 % were found, so that the frequency of LP in the total population is probably lower than the estimated 0.5-1.0 %.…”

Section: Epidemiologymentioning

confidence: 90%

“…LP can occur in its diverse cutaneous manifestations alone or in combination with mucosal lichen planus or in the event of subungual location with lichen planus of the nails. The frequency of mucosal involvement in LP patients is 30-70 % [1,15,16]. The subungual manifestations of LP take a special position.…”

Section: Epidemiologymentioning

confidence: 99%

“…As a rarity LP can develop at intertriginous sites, where it can completely lose its classical morphology (Figure 2). In analogy to psoriasis, the intertriginous presentation of LP is termed inverse lichen planus [1,16,21]. Subjectively, LP is characterized by a frequently agonizing pruritus that can affect up to 80 % of patients [9,16].…”

Section: Lichen Planusmentioning

confidence: 99%

“…Additionally, keratotic papules and erosions with a bizarre confi guration can occur (Figure 2). In the inverse locations, pigmentation of the individual lesions is also typical [1,21].…”

Section: Inverse Lichen Planusmentioning

confidence: 99%

“…Various potential triggers, e.g. viral or bacterial antigens, metal ions, drugs or physical factors, could initiate the autoimmune process [1,2]. Nonetheless, the role of the individual trigger factors is controversial.…”

Section: Introductionmentioning

confidence: 99%

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Clinical variants of lichen planus

Wagner

Rosé²,

Sachse

2013

J Deutsche Derma Gesell

100

132

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SummaryLichen planus is characterized by lichenoid, polygonal papules with fine white lines, called Wickham striae. Lesions most commonly occur on the limbs and on the dorsal aspect of the trunk. At the same time often leukoplakia of mucous membranes as well as nail disorders are seen.There are numerous variants of lichen planus which can be distinguished from the classical form on the basis of morphology and distribution of the lesions. The typical primary lesion of lichen planus may be replaced by other forms, such as patches, hyperkeratoses, ulcerations, or bullous lesions. Moreover, distribution patterns of these lesions may vary and include erythrodermic, inverse or linear arrangements. In contrast to these numerous clinical features, histologic findings remain characteristic in the variants, so that the diagnosis can be made securely. Differential diagnoses of lichen planus include diverse dermatoses such as bullous pemphigoid or paronychia.

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Section: Epidemiologymentioning

confidence: 90%

Section: Epidemiologymentioning

confidence: 99%

Section: Lichen Planusmentioning

confidence: 99%

“…Additionally, keratotic papules and erosions with a bizarre confi guration can occur (Figure 2). In the inverse locations, pigmentation of the individual lesions is also typical [1,21].…”

Section: Inverse Lichen Planusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical variants of lichen planus

Wagner

Rosé²,

Sachse

2013

J Deutsche Derma Gesell

100

132

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Violaceous Patches in the Axilla

Forbes

Petersen

2018

JAMA Dermatol

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Pigmented Plaque in the Axilla

Zhang

Gao

2020

JAMA Dermatol

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A woman in her 70s presented with an enlarged and variegated plaque on her left axilla, which she had had for 4 years. The lesion started as a small eczematous, pink-to-brown plaque. As the lesion was asymptomatic and slow growing, she did not initially seek treatment. Recently, the color of the lesion had changed to an alarming dark brown color (Figure , A). No breast mass or lymphadenopathy was observed. Her medical and family history was unremarkable. A skin biopsy specimen was obtained and submitted for further histopathologic analysis. Clinical image A Hematoxylin-eosin B EMA stain C HMB-45 stain D Figure. A, Clinical presentation of pigmented plaque in the axilla with well-demarcated margins. B, Histologic findings revealed an intraepidermal neoplasm consisting of pagetoid cells, characterized by round, pale, vacuolated cytoplasm, and large pleomorphic nuclei (hematoxylin-eosin; original magnification ×200). C, Immunohistochemical findings showed positive staining for EMA (original magnification ×200). D, The lesion was surrounded by numerous reactive dendritic HMB-45-positive melanocytes scattered among the tumor cells (original magnification ×200). WHAT IS YOUR DIAGNOSIS? A. Pagetoid Bowen disease B. Inverse lichen planus C. Pigmented extramammary Paget disease D. Superficial spreading melanoma Clinical Review & Education

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Lichen planus

Cited by 183 publications

References 128 publications

Clinical variants of lichen planus

Clinical variants of lichen planus

Violaceous Patches in the Axilla

Pigmented Plaque in the Axilla

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