Lichen nitidus of the palms and soles

Weiss, R. M.

doi:10.1001/archderm.104.5.538

Cited by 14 publications

(5 citation statements)

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“…Multinucleated giant cells can be observed in the epidermis (Table 1) [1–10]. The etiology of the giant cells can either be epithelial or histiocytic.…”

Section: Discussionmentioning

confidence: 99%

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Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a

Cohen

Paravar

Lee

2014

Dermatol Pract Concept

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Background:Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections.Purpose:To review the histologic differential diagnosis of conditions with epithelial and histiocytic multinucleated giant cells—since multinucleated giant cells in the epidermis are not always pathognomonic of a cutaneous herpes virus infection—and to summarize dermatoses in which herpes virus infection has been observed to coexist.Methods:Two individuals with acantholytic dermatoses whose initial lesional skin biopsies showed multinucleated epithelial giant cells suggestive of a herpes virus infection are reported. Using the PubMed database, an extensive literature search was performed on multinucleated giant cell (and epidermis, epithelial, and histiocytic) and herpes virus infection. Relevant papers were reviewed to discover the skin conditions with either multinucleated giant cells in the epidermis or coincident cutaneous herpes virus infection.Results:Initial skin biopsies from patients with either pemphigus vulgaris or transient acantholytic dermatosis mimicked herpes virus infection; however, laboratory studies and repeat biopsies established the correct diagnosis of their acantholytic dermatosis. Hence, epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection. Indeed, epithelial multinucleated giant cells in the epidermis can be observed not only in the presence of infection (herpes virus), but also acantholytic dermatoses and tumors (trichoepithelioma and pleomorphic basal cell carcinoma). Histiocytic multinucleated giant cells in the epidermis can be observed in patients with either giant cell lichenoid dermatitis or lichen nitidus of the palms.Conclusions:Epithelial and histiocytic multinucleated giant cell can occur in the epidermis. Keratinocyte-derived multinucleated giant cells are most commonly associated with herpes virus infection; yet, they can also be observed in patients with skin tumors or acantholytic dermatoses. Cutaneous herpes simplex virus infection can coexist in association with other conditions such as acantholytic dermatoses, benign skin tumors, bullous disorders, hematologic malignancies, inflammatory dermatoses, and physical therapies. However, when a herpes virus infection is suspected based upon the discovery of epithelial multinucleated giant cells in the epidermis, but either the clinic presentation or lack of response to viral therapy or absence of confirmatory laboratory studies does not support the diagnosis of a viral infection, the possibility of a primary acantholytic dermatosis should be considered and additional lesional skin biopsies performed. Also, because hematoxylin and eosin staining is not the golden standard for confirmation of autoimmune bullous dermatoses, skin biopsies for direct immunofluorescence should be performed when a primary bullous dermatosis is suspected since the histopathology observed on hematoxylin and eosin stai...

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“…Multinucleated giant cells can be observed in the epidermis (Table 1) [1–10]. The etiology of the giant cells can either be epithelial or histiocytic.…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of the giant cells can either be epithelial or histiocytic. Histiocytic epidermal multinucleated giant cells have been noted in giant cell lichenoid dermatitis [7,8] and lichen nitidus of the palms [9,10]. …”

Section: Discussionmentioning

confidence: 99%

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a

Cohen

Paravar

Lee

2014

Dermatol Pract Concept

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“…On the right, a convex decorative rivet is present, and above it, two torn-out rivet holes at the same height are visible, though these might be the result of antique restoration. 890 Vertical hammering traces are visible on the inside of the bronze sheet. Two lines of pellets parallel to the rim are similar to that found on the cuirass from the Danube.…”

Section: Cuirass Fragments and Potential Cuirass Findsmentioning

confidence: 99%

Protecting the Body in War and Combat

Mödlinger¹

2017

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Boundless thanks goes to the English-language editor of my manuscript, Steven Matthews. He saved the reader not only from questionable 'Denglish', but also, apart from such delightful stylistic pearls such as helmets floating in space ('30cm above the ground'), and other questionable things as a 'small cow plastic', significantly reduced many inconsistencies (I am afraid that some, nevertheless, remain). For all remaining oddities, errors, and assumptions I am the only one to blame.Last, but not least, the most special thanks go to my daughter Helene for the time I spent writing and not with her.

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“…The sites of predilection are the genitalia, trunk and extremities 2 , although the eruption can be generalized 3 . LN occurring on the palms, soles, nails and mucous membranes has been infrequently reported [4][5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

A Case of Palmar Lichen Nitidus Presenting as a Clinical Feature of Pompholyx

et al. 2010

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Lichen nitidus (LN) is an uncommon chronic eruption of an unknown cause, and it is characterized by tiny, discrete, flesh-colored papules. The sites of predilection are the genitalia, trunk and extremities. Unilateral palmar involvement with pruritus is infrequent. We report here on a case of LN confined to the right palm, and the patient presented with multiple, pruritic, erythematous to flesh-colored, tiny papules and vesicles that mimicked pompholyx. The histopathological examination of a skin biopsy specimen showed the typical findings of LN. (Ann Dermatol 22(2) 235

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Lichen nitidus of the palms and soles

Cited by 14 publications

References 0 publications

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a

Protecting the Body in War and Combat

A Case of Palmar Lichen Nitidus Presenting as a Clinical Feature of Pompholyx

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