Lichen Aureus

Fink‐Puches, Regina; Wolf, Peter; Kerl, Helmut; Cerroni, Lorenzo

doi:10.1001/archderm.144.9.1169

Cited by 55 publications

(10 citation statements)

References 25 publications

(25 reference statements)

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“…Similar results were documented by Fritsch and colleagues in a study about the porphyrin accumulation generated by ALA applied on SCC and BCC [11]. In addition, several studies have used 4-6 hours as time of ALA incubation prior the PDT irradiation in the treatment of AK [16][17][18][19][20], BD [16,[21][22][23] and sBCC [16,[24][25][26][27]]. Figure 4 shows the kinetic evaluation of fluorescence measurements collected from healthy skin non-submitted to the photosensitizing ointment, as well as neoplastic and healthy tissue that underwent MAL cream.…”

Section: Kinetic Evaluation Of Ppix Generated By Alasupporting

confidence: 71%

Optimization and therapeutic effects of PDT mediated by ALA and MAL in the treatment of cutaneous malignant lesions: A comparative study

Lima

Goulart

Bechara

et al. 2016

Journal of Biophotonics

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5-aminolevulinic acid (ALA) and its methylated ester (MAL) are the most common topical agents used in photodynamic therapy (PDT) as precursors of the photosensitizer protoporphyrin IX (PpIX). The induction of newly PpIX depends on incubation time of each photosensitizer in the tissue and the presence of high intralesional porphyrin levels is an important parameter for the PDT effectiveness. This study used laser-induced fluorescence (LIF) spectroscopy to evaluate the optimum time to light exposure of PDT mediated by ALA (20% w/w) and MAL (10% w/w) to treat malignant lesions precursors of cutaneous squamous cell carcinoma induced in mice. The therapeutic effects obtained by optimized ALA- and MAL-PDT were assessed 10 and 20 days after treatments. Higher PpIX levels were evidenced in the lesions photosensitized by ALA than MAL and according to LIF measurements the PDT irradiation was performed, respectively, at 300 and 330 minutes after ALA and MAL incubation. Histopathological analysis evidenced necrosis and epithelial atrophy after 10 days of PDT using both prodrugs, as well as reepitelization and collagen deposition at 20 days. Thus, despite the distinct concentration of ALA and MAL used in the formulation of each photosensitizing cream, PDT mediated by both photosensitizing agents obtained similar therapeutic outcomes.

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Section: Kinetic Evaluation Of Ppix Generated By Alasupporting

confidence: 71%

Optimization and therapeutic effects of PDT mediated by ALA and MAL in the treatment of cutaneous malignant lesions: A comparative study

Lima

Goulart

Bechara

et al. 2016

Journal of Biophotonics

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“…In such cases, associated dermatopathological findings may also closely imitate its benign counterpart, i.e., psoriasiform epidermal hyperplasia in psoriasis vulgaris-like variants of mycosis fungoides, subepidermal blisters in bullous pemphigoid-like presentations, interstitial histiocytes and giant cells in granuloma annulare-like mycosis fungoides, or interface dermatitis in mycosis fungoides with lichen planus-like skin lesions [8,9]. In our case, the histopathology of the first biopsy corresponds to an unusual lichen planopilaris.…”

Section: Discussionmentioning

confidence: 99%

Reflectance Confocal Microscopy as New Diagnostic Tool in Folliculotropic Mycosis Fungoides

Fabbrocini¹,

Mazzella²,

Cantelli³

et al. 2017

Skin Appendage Disord

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We present a case of folliculotropic mycosis fungoides (FMF), a variant of cutaneous T-cell lymphoma which particularly affects hair follicles. FMF can imitate a wide variety of otherwise benign dermatoses, so it poses major diagnostic obstacles both for the dermatologist as well as the dermatopathologist. In our case, in vivo reflectance confocal microscopy (RCM) was very important for guiding the skin biopsy site selection. For this reason, RCM can reduce the number of unsuccessful histopathological examinations and increase the diagnostic accuracy for different skin dermatoses.

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“…Some authors have questioned its chronic and benign nature, suggesting that LA may progress to mycosis fungoids, but a follow-up of 23 patients did not identify any case with this progression. 5 …”

Section: Discussionmentioning

confidence: 99%

Agminate lichen aureus

Tortelly

Silva

Mota

et al. 2013

An. Bras. Dermatol.

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Lichen aureus is a rare variant of pigmented purpura, with a chronic and benign course. It is generally asymptomatic and often occurs in the lower limbs, presenting as erythematous brownish, coppery or golden macules and/or papules. The diagnosis is based on clinical and histopathological findings. The dermatoscopic pattern has been considered a useful tool in diagnosis presumption. We describe a case with a confluent morphological pattern, called agminate lichen aureus.

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Lichen Aureus

Cited by 55 publications

References 25 publications

Optimization and therapeutic effects of PDT mediated by ALA and MAL in the treatment of cutaneous malignant lesions: A comparative study

Optimization and therapeutic effects of PDT mediated by ALA and MAL in the treatment of cutaneous malignant lesions: A comparative study

Reflectance Confocal Microscopy as New Diagnostic Tool in Folliculotropic Mycosis Fungoides

Agminate lichen aureus

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