LIBO—a linac-booster for protontherapy: construction and tests of a prototype

Amaldi, U.; Berra, P. Bruce; Crandall, K.R.; Toet, D. Z.; Weiss, M.; Zennaro, R.; Rosso, E.; Szeless, B.; Vretenar, M.; Cicardi, C.; Martinis, C. De; Giove, D.; Davino, D.; Masullo, M.R.; Vaccaro, V. G.

doi:10.1016/j.nima.2003.07.062

Cited by 59 publications

(33 citation statements)

References 13 publications

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“…The energy and the dose are at the threshold of clinical relevance. Acceleration to higher energies is possible using another stage such as the linac booster [47][48][49]. Supposing that these results can be confirmed in a single shot experiment, important technological developments are necessary to reach the 10 Hz maximum laser repetition rate in a stable and reliable way.…”

Section: Discussionmentioning

confidence: 99%

Transport and energy selection of laser generated protons for postacceleration with a compact linac

Sinigardi

Turchetti

Londrillo

et al. 2013

Phys. Rev. ST Accel. Beams

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Laser accelerated proton beams have a considerable potential for various applications including oncological therapy. However, the most consolidated target normal sheath acceleration regime based on irradiation of solid targets provides an exponential energy spectrum with a significant divergence. The low count number at the cutoff energy seriously limits at present its possible use. One realistic scenario for the near future is offered by hybrid schemes. The use of transport lines for collimation and energy selection has been considered. We present here a scheme based on a high field pulsed solenoid and collimators which allows one to select a beam suitable for injection at 30 MeV into a compact linac in order to double its energy while preserving a significant intensity. The results are based on a fully 3D simulation starting from laser acceleration.

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Section: Discussionmentioning

confidence: 99%

Transport and energy selection of laser generated protons for postacceleration with a compact linac

Sinigardi

Turchetti

Londrillo

et al. 2013

Phys. Rev. ST Accel. Beams

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“…CERN also contributed to the design, construction and testing of a high-gradient proton linear accelerator operating at 3 GHz. Such a linac in conjunction with a cyclotron could provide a compact facility [31].…”

Section: Kurt Hübnermentioning

confidence: 99%

Knowledge and Technology: Sharing With Society

Benvenuti¹,

Sutton²,

Wenninger³

2017

Advanced Series on Directions in High Energy Physics

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Education and basic research are large costs to society, which governments, in general, accept as a necessary long-term investment. Still, it is fair to ask how this investment can be used to the best overall benefit for society.Many excellent reports and talks [1][2][3][4][5] describe how basic research, motivated by "curiosity" -the desire to extend our understanding of nature -contributes as much to innovation as do the applied sciences, which focus on solving specific problems. Both stimulate industry and advance technology.Consider the core technologies of high energy particle physics. Accelerator applications range from killing bacteria and treating cancer, to welding and cutting, hardening materials, reducing harmful gas emissions from thermal power plants, and much more. Particle detectors are not only ubiquitous in medical imaging; they are also used, for example, by volcanologists and archaeologists to image sites of potential interest. Computer simulation toolkits developed for particle physics have become essential in other fields, including medicine, aerospace, and nano-science.Complex instruments and cutting-edge technologies are required for the construction and operation of accelerators and intricate detectors, as well as for managing the wealth of data they produce. When existing technologies are inadequate to meet requirements, developments are triggered that often give rise to technological innovations. Most famously, the World Wide Web, which was invented at CERN in the late 1980s to allow automatic sharing of information for scientists, has revolutionized global communication with enormous social and economic impact. Three decades later, data-handling and analysis needs for research at the LHC continue to push forward the evolution of worldwide distributed grid computing, bringing benefits to bio-computing and health sciences, astrophysics, environmental studies, and others.

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“…However, in recent years several developments have been made to achieve high enough gradients to enable use in a hospital setting, for example by the TERA and TOP-IMPART collaborations (greater than 10 MV m −1 ) [94][95][96][97][98]. In both these cases 3 GHz normal-conducting accelerating structures have been proposed to achieve gradients above 20 MV m −1 ; in the case of the TERA LIBO proton linac a side-coupled linac is used [99], and has been chosen by at least one commercial company (Advanced Oncotherapy) as a technology to be integrated for patient treatment [100].…”

Section: Linacsmentioning

confidence: 99%

Hadron accelerators for radiotherapy

Owen

Mackay

Peach

et al. 2014

Contemporary Physics

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Over the last twenty years the treatment of cancer with protons and light nuclei such as carbon ions has moved from being the preserve of research laboratories into widespread clinical use. A number of choices now exist for the creation and delivery of these particles, key amongst these being the adoption of pencil beam scanning using a rotating gantry; attention is now being given to what technologies will enable cheaper and more effective treatment in the future. In this article the physics and engineering used in these hadron therapy facilities is presented, and the research areas likely to lead to substantive improvements. The wider use of superconducting magnets is an emerging trend, whilst further ahead novel high-gradient acceleration techniques may enable much smaller treatment systems. Imaging techniques to improve the accuracy of treatment plans must also be developed hand-in-hand with future sources of particles, a notable example of which is proton computed tomography.

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LIBO—a linac-booster for protontherapy: construction and tests of a prototype

Cited by 59 publications

References 13 publications

Transport and energy selection of laser generated protons for postacceleration with a compact linac

Transport and energy selection of laser generated protons for postacceleration with a compact linac

Knowledge and Technology: Sharing With Society

Hadron accelerators for radiotherapy

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