Libidibia ferrea extract as a promising antidiabetic agent: characterization, pre-clinical analysis and development of pharmaceutical dosage forms / Extrato de Libidibia ferrea como um promissor agente antidiabético: caracterização, análise pré-clínica e desenvolvimento de formas de dosagem farmacêutica

Abstract

The present work aimed at developing pharmaceutical dosage forms based on the dry bark extract of Libidibia ferrea for the treatment of diabetes mellitus. The physicochemical characterization of the plant raw material, extractive solution and dry extract obtained by freeze drying were carried out. Effervescent granules, oral solution and tablets from the dry extract were developed and subjected to the recommended quality control tests. All materials presented standardized values after physical-chemical characterization. The presence of several secondary compounds was confirmed, and the content of the tannins was determined. The extract did not present acute toxicity in the in vivo experiment and provided an increase in glucose uptake in the in vitro study. The developed formulations complied with previously established values for quality control. The results show the safety and efficacy of the developed products, may being promising options in the treatment of diabetes mellitus.

Avaliação de constituintes bioativos e atividade antioxidante do extrato seco de Libidibia ferrea (Mart. ex Tul.) LP Queiroz

“…Possui diversas aplicações populares, sendo chá (decocção e infusão), lambedor e garrafada suas principais formas de uso (Balbach, 1992;Maia, 2004;Agra, Freitas e Barbosa-Filho, 2007;Ferreira e Soares, 2015). Apresenta diversas propriedades farmacológicas que foram cientificamente comprovadas ao longo do tempo, como: ação anti-hiperglicemiante (Vasconcelos et al, 2011;Lima et al, 2021) atividade antibacteriana (Sampaio et al, 2009); atividade microbiológica (Farias et al, 2020); atividade anti-hipertensiva (Menezes et al, 2007); atividade cicatrizante (Melo et al, 2020); atividade anticancerígena (Nakamura et al, 2002); atividade analgésica (Carvalho et al, 1996); atividade anti-inflamatória e antiulcerogênica (Bacchi et al, 1995); atividade anticâncer (Nozaki et al, 2007).…”