Liberté, Liberté Chérie

Perbal, Bernard; Perbal, Annick

doi:10.1007/s12079-015-0270-1

Cited by 3 publications

(3 citation statements)

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“…Preliminary data from our team indicate high production of CCN3 by lymphocyte infiltrating the dermis in vitiligo. Moreover, CCN3 expression is regulated by TNF‐α and IL‐1, and CCN3 physically interacts with IL33, a T‐helper‐2 associated cytokine able to induce fibrosis in SSc …”

Section: Ccn Proteins In Dermal Inflammation and Autoimmunitymentioning

confidence: 99%

CCN proteins as potential actionable targets in scleroderma

Henrot

Truchetet

Fisher

et al. 2018

Experimental Dermatology

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Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease combining inflammatory, vasculopathic and fibrotic manifestations. Skin features, which give their name to the disease and are considered as diagnostic as well as prognostic markers, have not been thoroughly investigated in terms of therapeutic targets. CCN proteins (CYR61/CCN1, CTGF/CCN2, NOV/CCN3 and WISP1‐2‐3 as CCN4‐5‐6) are a family of secreted matricellular proteins implicated in major cellular processes such as cell growth, migration, differentiation. They have already been implicated in key pathophysiological processes of SSc, namely fibrosis, vasculopathy and inflammation. In this review, we discuss the possible implication of CCN proteins in SSc pathogenesis, with a special focus on skin features, and identify the potential actionable CCN targets.

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Section: Ccn Proteins In Dermal Inflammation and Autoimmunitymentioning

confidence: 99%

CCN proteins as potential actionable targets in scleroderma

Henrot

Truchetet

Fisher

et al. 2018

Experimental Dermatology

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“…El impacto general social del atentado contra Charlie Hebdo ultrapasa el ámbito de estudio del derecho a la información y se ha tomado como un estandarte mismo de la libertad, que han llegado a defender revistas de todos los ámbitos (Perbal, 2015). La psicología también lo ha abordado desde el punto de vista del trauma colectivo (Ben Ezra, Leshem y Goodwin, 2015).…”

Section: Terrorismo Y Religión Como Showunclassified

Elementos de espectacularización en los informativos televisivos de ‘prime time’: el caso de ‘Charlie Hebdo’

Montero¹,

Pavía

2017

(OBS*)

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El objetivo principal del presente artículo es analizar si el tratamiento dado por los informativos de prime time de la cadena privada española Telecinco a las noticias sobre el atentado al semanario satírico Charlie Hebdo, perpetrado el 7 de enero de 2015 en París, se puede considerar espectacularizado. Este hecho tuvo una transcendencia mundial y aún se localiza poca investigación sobre sus aspectos comunicativos. A través del análisis de contenido, con creación de categorías múltiples, se ha podido obtener datos a lo largo de 14 días de emisión, con un análisis global de 99 noticias, que nos aproxima a las técnicas empleadas en la cobertura de este evento, tanto desde el punto de vista de la imagen como del texto verbal. En los resultados, tanto de tipo cuantitativo como cualitativo, se ha podido constatar que ha habido un tratamiento espectacularizado, apoyado en la dramatización, el conflicto, la explotación de las imágenes, la exageración y la fragmentación, generando una tematización extrema del caso Charlie Hebdo. Esto llama a la reflexión, no sólo por las técnicas detectadas en la construcción de la noticia, sino por cómo otras informaciones de igual o mayor relevancia quedan de lado, ausentes en el conocimiento del público.

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“…More recently, SP has been shown as involved in inflammation via its production by many immune cell subtypes [13–15], and in fibrotic disorders, such as in lungs and intestines via its production by fibroblasts [16, 17]. In musculoskeletal tissues, SP has been implicated in the pathogenesis of tendinosis in patients [18], and in tendon loading models in rats and rabbits in which loading-induced increases in endogenous SP occur prior to an increase in tenocyte hypercellularity [14, 19–21]. TGFβ-1 and SP can work in concert for enhanced fibroblast proliferation or collagen production (although not yet investigated specifically in tenocytes), either via TGFβ-1 mediated SP receptor regulation [22], transcriptional modulation of each other [16, 23, 24], or through cooperative signaling of these two molecules [17, 25].…”

Section: Introductionmentioning

confidence: 99%

Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes

Frara

Fisher

Zhao

et al. 2017

Connective Tissue Research

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Transforming growth factor beta 1 (TGFbeta-1) and connective tissue growth factor (CCN2) are important mediators of tissue repair and fibrosis, with CCN2 functioning as a downstream mediator of TGFβ-1. Substance P (SP) is also linked to collagen production in tenocytes. A link between SP, TGFbeta-1 and CCN2 has yet to be established in tenocytes or fibrogenic processes. We sought to determine whether SP induces tenocyte proliferation, CCN2, or collagen production via TGFbeta-1 signaling or independently in rat primary tenocytes. Tenocytes were isolated from rat tendons, cultured and stimulated by SP and/or TGFbeta-1. Cultured cells expressed proteins characteristic of tenocytes (vimentin and tenomodulin) and underwent increased proliferation dose dependently after SP and TGFbeta-1 treatments, alone or combined (more than SP alone when combined). SP induced TGFbeta-1 expression in tenocytes in both dose- and time-dependent manners. SP and TGFbeta-1, alone or combined, stimulated CCN2 expression in tenocytes and their supernatants after both 24 and 48 h of stimulation; a response blocked with addition of a TGFbeta-1 receptor inhibitor. In contrast, SP potentiated collagen type I secretion by tenocytes, a response abrogated by the TGFbeta-1 receptor inhibitor after 48 h of stimulation, but not after the shorter 24 h of stimulation. Our findings suggest that both SP and TGFbeta-1 can stimulate tenocyte fibrogenic processes, albeit differently. TGFbeta-1 pathway signaling was involved in CCN2 production at all time points examined, while SP induced collagen type I production independently prior to the onset of signaling through the TGFbeta-1 pathway.

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Liberté, Liberté Chérie

Cited by 3 publications

References 0 publications

CCN proteins as potential actionable targets in scleroderma

CCN proteins as potential actionable targets in scleroderma

Elementos de espectacularización en los informativos televisivos de ‘prime time’: el caso de ‘Charlie Hebdo’

Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes

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