Leydig cell tumour of the testis: a rare cause of male infertility

Mostafid, Hugh; Nawrocki, John F.; Fletcher, M. S.; Vaughan, N.J.A.; Melcher, D.H.

doi:10.1046/j.1464-410x.1998.00401.x

Cited by 7 publications

(6 citation statements)

References 5 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scrotal ultrasonography is the primary imaging method used in the diagnosis, however, investigation of tumor markers, hormones (testosterone, LH, FSH, estrogen, estradiol, progesterone and cortisol) and CT examination of chest and abdomen for distant metastasis should be performed. As in our patient, cases of Leydig cell tumors incidentally diagnosed during infertility investigation have been reported in the literature (5,6).…”

Section: Discussionsupporting

confidence: 62%

Leydig Cell Tumor of the Testis: A Case with Incidental Diagnosis

Eren¹,

Aydın²,

Aldemir³

et al. 2019

jus

View full text Add to dashboard Cite

Leydig hücreli tümörler, yetişkin testis tümörlerinin yaklaşık %1-3'ünü oluşturmaktadır. Bu tümörler gonadal stromal tümörlerin en sık rastlanan türü olup, erkeklerde en yaygın 3 ile 6. dekatlarda görülürler. Leydig hücre tümörlerinin yaklaşık %10'u maligndir. Bu yazıda primer infertilite nedeniyle araştırılan bir hastada insidental tanı konan bir Leydig hücreli testis tümörü olgusu sunmaktayız. Yirmi sekiz yaşında evli bir erkek hasta primer infertilite şikayeti ile kliniğimize başvurdu ve skrotal ultrasonografi incelemesinde sol testiste heterojen ve hipoekoik bir kitlesi olduğu görüldü. Hastaya sol radikal orşiektomi uygulandı ve patoloji sonucu testis Leydig hücreli tümörü olarak raporlandı. Toraks ve batın bilgisayarlı tomografisinde uzak metastaz saptanmadı ve hasta takibe alındı. Anahtar Kelimeler: İnfertilite, Leydig hücreli tümör, Testiküler neoplaziler, İnguinal orşiektomi Leydig cell tumors account for approximately 1-3% of adult testicular tumors. These tumors are the most common type of gonadal stromal tumors and most commonly seen in the third to sixth decades of life, and about 10% of them are malignant. This case is about an incidentally diagnosed Leydig cell testis tumor in a patient who was investigated for primary infertility. A 28-year-old male patient presented with primary infertility and scrotal ultrasonography examination revealed a heterogeneous hypoechoic mass in the left testicle. He underwent left radical orchiectomy and pathological diagnosis was testicular Leydig cell tumor. There was no distant metastasis and the patient is being followed for metastasis.

show abstract

Section: Discussionsupporting

confidence: 62%

Leydig Cell Tumor of the Testis: A Case with Incidental Diagnosis

Eren¹,

Aydın²,

Aldemir³

et al. 2019

jus

View full text Add to dashboard Cite

show abstract

“…Although a study evaluating spermatogenesis in men with non‐germ cell tumors of the testis reported normal spermatogenesis in five patients with Leydig cell tumors, 3 none of the four patients presented in this study had normal spermatogenesis. There have been only three previously reported cases of azoospermic men with Leydig cell tumors 4,5 . The hormonal imbalance due to Leydig cell tumor may cause azoospermia as reported in cases 1 and 3, even in the case of normal endocrinological findings as presented in case 2.…”

Section: Discussionmentioning

confidence: 94%

Leydig cell tumor of the testis: Comparison of histopathological and immunohistochemical features of three azoospermic cases and one malignant case

Hekımgıl¹,

Altay²,

Yakut³

et al. 2001

Pathology International

View full text Add to dashboard Cite

Leydig cell tumors of the testis are rare, mostly presenting as a testicular mass or as endocrinological symptoms. Here, three patients who were admitted for investigation of primary infertility and one patient presenting with a testicular mass are reported. The histological features were reviewed and an immunohistochemical study was done using a panel of antibodies against cytokeratin, vimentin, inhibin A, S-100, Ki-67, follicle-stimulating hormone, luteinizing hormone, prolactin, p53, bcl-2, and c-erbB2. The latter case (lost during follow up of metastatic disease) demonstrated massive tumor necrosis, extension through the tunica albuginea, and a high mitotic activity and MIB-1 score. Only this malignant case was bcl-2 positive. Of the two oncogenic markers studied, none of the cases were positive for c-erb2, while p53 was positive in more than 50% of cells in the malignant case and in one case of infertility with a large tumor, hemorrhage, focal necrosis and atypical cytological features. We recommend the evaluation of infertile men for Leydig cell tumors, and we believe that a panel of antibodies, including Ki-67, p53 and bcl-2, used for immunohistochemical analysis could be of diagnostic value in the identification of malignant and borderline cases of Leydig cell tumor.

show abstract

“…This appears to be in agreement with other (rare) reports of patients with Leydig cell tumors and reversible azoospermia, who did not suffer from other testicular disorders. Interestingly, in these previous reports, the patients were also found to have testosterone secreting Leydig cell tumors with undetectable [15] or markedly reduced [12] gonadotropin levels, which suggests that intratesticular secretion of testosterone by the tumor is not sufficient to prevent azoospermia in spite of marked suppression of LH and FSH secretion. The present paper shows that even with collapsed gonadotropin levels TESE allowed extraction of spermatozoa.…”

Section: Discussionmentioning

confidence: 98%

Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report

Prasivoravong

Barbotin

Derveaux

et al. 2016

Basic Clin. Androl.

View full text Add to dashboard Cite

BackgroundSecreting interstitial cell (Leydig cell) tumors are rare. In adults, the clinical picture and steroid levels are variable.Case presentationThis paper presents a case of left testicular tumor, showing azoospermia with normal serum level of total testosterone, collapsed FSH and LH, and high delta4 androstenedione. Histopathological investigation revealed a Leydig cell tumor. TESE allowed spermatozoa extraction and freezing. Testicular histology found hypospermatogenesis and germ-cell aplasia with interstitial fibrosis. Surgical resection of the tumor resulted in normalization of gonadotropins and fall in serum delta4 androstenedione to subnormal levels in the postoperative period confirming that the tumor was secreting delta4 androstenedione. It was hypothesized that high delta4 androstenedione resulted in intra tumoral 17 β-HSD overtaken by delta4 androstenedione or that 17 β-HSD activity in the tumor was different from that of normal Leydig cells. Three months after surgery sperm analysis found a complete recovery of spermatogenesis. A spontaneous pregnancy occurred 3 months after surgery and a girl was born.ConclusionsIn this case, the diagnosis of testicular Leydig cell tumor secreting delta4 androstenedione was made in a context of azoospermia.

show abstract

Leydig cell tumour of the testis: a rare cause of male infertility

Cited by 7 publications

References 5 publications

Leydig Cell Tumor of the Testis: A Case with Incidental Diagnosis

Leydig Cell Tumor of the Testis: A Case with Incidental Diagnosis

Leydig cell tumor of the testis: Comparison of histopathological and immunohistochemical features of three azoospermic cases and one malignant case

Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report

Contact Info

Product

Resources

About