Leydig cell tumor of intra-abdominal testis

Allen, F. J.; Vollenhoven, E. Van

doi:10.1016/0090-4295(93)90546-m

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…Although LCTs were not described within this spectrum, the finding of associated anomalies in nonneoplastic testicular parenchyma adjacent to these tumours could help to understand their pathogenesis. There are only a few studies in which the parenchyma adjacent to LCTs is mentioned (Kim et al, 1985;Allen & van Vollenhoven, 1993;Ho et al, 1994;Hekimgil et al, 2001). Here, we provide a detailed study of the nontumoural parenchyma of 16 LCT cases in order to address their possible pathogenic mechanisms.…”

Section: Discussionmentioning

confidence: 94%

“…Although the pathogenesis of LCTs is unknown, their association with other primary testicular abnormalities may be relevant to improve our understanding of their development. The occurrence of LCT in cryptorchid testes (Deshmukh, 1982;Kim et al, 1985;Allen & van Vollenhoven, 1993;Kirsch et al, 1993;Safak et al, 1994;Calleja et al, 1999), as well as its association with germ cell neoplasms (Fink et al, 1984;Dieckmann & Loy, 1993;Heidenreich et al, 1997), have been reported in the literature, and could point towards a common pre-disposing factor. Our group recently reported a number of findings in the testicular parenchyma adjacent to germ cell tumours (Nistal et al, 2006), which, in addition to the previously reported features (Petersen et al, 1998;Hoei-Hansen et al, 2003), support an association between these neoplasms and other primary testicular lesions.…”

Section: Discussionmentioning

confidence: 97%

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Non‐tumoural parenchyma in Leydig cell tumours: pathogenetic considerations

et al. 2007

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Little is known about the pathogenesis of Leydig cell tumours (LCTs) of the testis. The observation of several associated dysgenetic features in the non-tumoural parenchyma and in the contralateral testes of men with testicular germ cell neoplasms has served as the basis to propose that there may be a common mechanism for different male reproductive disorders. However, the possible relationship between LCTs and other testicular lesions has not been explored. Here we describe the presence of primary lesions in the non-tumoural parenchyma of testes with LCT, from which we try to establish possible pathogenetic associations. We studied the non-tumoural parenchyma adjacent to 16 LCT specimens. Parameters as Leydig cell hyperplasia (LCHY), qualitative evaluation of the germinal epithelium and spermatogenesis, the presence of Sertoli cell-only tubules (SCOT), and the Sertoli cell nuclear morphology were consistently assessed in all cases. SCOT associated with Sertoli cell dysgenetic morphology was the most frequent finding, present in 50% of the cases. Another interesting finding was the presence of LCHY in four cases (25%). Abnormal spermatogenesis was found in 81.25% of the cases, and it consisted of lesions of the adluminal or basal compartments of seminiferous tubules. The occurrence of either dysgenetic Sertoli cells or LCHY adjacent to LCTs could represent primary anomalies, resulting from a common insult also involved in tumourigenesis. The abnormalities in spermatogenesis observed here are likely to represent consequences of either tumour compression or abnormal hormonal production. The significance of these associations merits further investigation regarding a common pathogenesis.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Non‐tumoural parenchyma in Leydig cell tumours: pathogenetic considerations

et al. 2007

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“…There are ≈300 reported cases of Leydig cell tumour; ≈3% were bilateral and endocrinological signs were present in ≈20%. Two case reports associate cryptorchidism with Leydig cell tumours; Sufak et al [1] reported a patient with bilateral Leydig cell tumour in association with a unilateral undescended testicle and another report described bilateral intra‐abdominal testicles presenting with gynaecomastia caused by an endocrine‐secreting unilateral Leydig cell tumour [2]. The only certain mode of differentiation between benign and malignant potential is the presence or absence of metastases that are highly resistant to both radio‐ and chemotherapy.…”

Section: Commentmentioning

confidence: 99%

Unilateral Leydig cell tumour associated with a contralateral undescended testis

1999

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“…These tumors are associated with increased production of androgens or estrogens, resulting in a wide variety of hormonal manifestations, such as gynecomastia, precocious puberty, and decreased libido. [1][2][3][4] In approximately 40% of cases, patients have testicular swelling, which may or may not be associated with a palpable mass. In addition, endocrinopathy is found in about 30% of cases.…”

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confidence: 99%

“…5 Sonography is an important tool in evaluation of the scrotum, and an increasing number of benign and incidental lesions are being reported. [5][6][7] There are, however, scant references to the sonographic appearance of LCTs in the literature, 1,3,[8][9][10][11][12] and the tumor is described as having a variable appearance, indistinguishable from germ cell tumors. 4 This retrospective study was undertaken to analyze the gray scale and color Doppler sonographic features of 10 LCTs.…”

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confidence: 99%