Leydig cell hyperplasia and adenoma formation: Mechanisms and relevance to humans

Clegg, Eric D.; Cook, Jon C.; Chapin, Robert E.; Foster, Paul M.D.; Daston, George P.

doi:10.1016/s0890-6238(96)00203-1

Cited by 117 publications

(78 citation statements)

References 109 publications

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“…Dopamine agonists and other chemicals, such as methoxychlor, carbamazepine, and o,p′-DDD, shown to inhibit oocyte maturation in fishes, have been shown to induce Leydig cell hyperplasia and adenomas in mammalian species (reviewed by Clegg et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay

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Pinkney

Jenkins

et al. 2013

Science of The Total Environment

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Iwanowicz, Luke R.; Minkkinen, Steven; Draugelis-Dale, Rassa O.; and Uphoff, James H., "Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay" (2013 H I G H L I G H T S► Reduced recruitment of yellow perch has occurred in urban tributaries of Chesapeake Bay. ► We compared reproductive health biomarkers in perch from two urban, one developing, two less developed watersheds. ► Lack of final maturation, abnormal yolk and zona pellucida were noted in females. ► Leydig cell proliferation was noted in males. Reduced recruitment of yellow perch has been noted for a number of years in certain urbanized watersheds (South and Severn Rivers) of the Chesapeake Bay. Other rapidly developing watersheds such as Mattawoman Creek are more recently showing evidence of reduced recruitment of anadromous fishes. In this study, we used a battery of biomarkers to better document the reproductive health of adult yellow perch collected during spring spawning in [2007][2008][2009]. Perch were collected in the South and Severn Rivers, Mattawoman Creek and the less developed Choptank and Allen's Fresh watersheds for comparison. Gonadosomatic indices, plasma reproductive hormone concentrations, plasma vitellogenin concentrations and gonad histology were evaluated in mature perch of both sexes. In addition, sperm quantity (cell counts) and quality (total and progressive motility, spermatogenic stage and DNA integrity), were measured in male perch. Many of these biomarkers varied annually and spatially, with some interesting statistical results and trends. Male perch from the Choptank and Allen's Fresh had generally higher sperm counts. In 2008 counts were significantly lower in the perch from the Severn when compared to other sites. The major microscopic gonadal abnormality in males was the proliferation of putative Leydig cells, observed in testes from Severn and less commonly, Mattawoman Creek perch. Observations that could significantly impact egg viability were an apparent lack of final maturation, abnormal yolk and thin, irregular zona pellucida. These were observed primarily in ovaries from Severn, South and less commonly Mattawoman Creek perch. The potential association of these observations with urbanization, impervious surface and chemical contaminants is discussed. a b s t r a c t a r t i c l e i n f oPublished by Elsevier B.V.

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Section: Discussionmentioning

confidence: 99%

Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay

Blazer

Pinkney

Jenkins

et al. 2013

Science of The Total Environment

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“…25,42 There is clear evidence that LH plays a pivotal role in development of the Leydig cell population and stimulating T production in adults. 43,44 In addition, LH is believed to be the main trophic hormone that causes Leydig cell adenomas, 43 while there is evidence showing that estrogens induce Leydig cell adenomas via their ability to increase LH action in certain strains of mice. 45,46 However, our recent study showed that mice with a marked overexpression of hCG do not develop Leydig cell hyperplasia in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Multiple Structural and Functional Abnormalities in the P450 Aromatase Expressing Transgenic Male Mice Are Ameliorated by a P450 Aromatase Inhibitor

Strauss

Mäkelä

et al. 2004

The American Journal of Pathology

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The present study was undertaken to analyze the effect of a P450 aromatase inhibitor (finrozole) on 4-month-old transgenic mice expressing human P450 aromatase (P450arom) under the human ubiquitin C promoter (AROM؉). AROM؉ mice present several dysfunctions, such as adrenal and pituitary hyperplasia, cryptorchidism, Leydig cell hypertrophy and hyperplasia, and gynecomastia. The present study demonstrates that these abnormalities were efficiently treated by administration of a P450arom inhibitor, finrozole. The treatment normalized the reduced intratesticular and serum testosterone levels, while those of estradiol were decreased. The body weight and several affected organ weights were normalized with the treatment. Histological analysis revealed that both the pituitary and adrenal hyperplasia were diminished. Furthermore, the cryptorchid testes present in the untreated AROM؉ males descended to scrotum, 4 to 15 days after inhibitor treatment. In addition, the disrupted spermatogenesis was recovered and qualitatively complete spermatogenesis appeared with the inhibitor treatment. This was associated with normalized structure of the interstitial

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“…In rats, PFOA is a peroxisome proliferator activated receptor (PPAR) agonist causing liver toxicity (12,13) with hepatomegaly and hepatic necrosis, and biochemical effects characteristic of PPAR agonists (14). PFOA promotes liver carcinogenesis in rats (15), and causes Leydig-cell testicular tumors and acinar cell pancreatic tumors (16,17), through non-genotoxic mechanisms (18,19) with questionable human relevance. The human half-life of PFOA was between four and five years for retirees with previous heavy occupational exposure (20), much longer than in laboratory animals.…”

Section: Introductionmentioning

confidence: 99%

Community Exposure to Perfluorooctanoate: Relationships Between Serum Concentrations and Exposure Sources

Emmett

Shofer

Zhang

et al. 2006

Journal of Occupational and Environmental Medicine

314

300

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Objective-To determine serum [PFOA] in residents near a fluoropolymer production facility: the contributions from air, water and occupational exposures, personal and dietary habits, and relationships to age and gender.Methods-Questionnaire and serum PFOA measurements in a stratified random sample and volunteers residing in locations with the same residential water supply but with higher and lower potential air PFOA exposure. [PFOA] greatly exceeded general population medians. Occupational exposure from production processes using PFOA and residential water had additive effects, no other occupations contributed. Serum [PFOA] depended on the source of residential drinking water, and not potential air exposure. For public water users the best-fit model included age, tap water drinks per day, servings of home-grown fruit and vegetables, and carbon filter use. Results-SerumConclusions-Residential water source was the primary determinant of serum [PFOA].

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Leydig cell hyperplasia and adenoma formation: Mechanisms and relevance to humans

Cited by 117 publications

References 109 publications

Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay

Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay

Multiple Structural and Functional Abnormalities in the P450 Aromatase Expressing Transgenic Male Mice Are Ameliorated by a P450 Aromatase Inhibitor

Community Exposure to Perfluorooctanoate: Relationships Between Serum Concentrations and Exposure Sources

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