Levosimendan: current status and future prospects

Abstract

Levosimendan is an established substance in the treatment of acute heart failure in several countries despite disappointing findings concerning a possible survival benefit in two recent clinical trials. Owing to its alternative mechanisms of action as compared with traditional cardiotonic agents, several promising clinical applications have arisen. Available evidence for the use of levosimendan in settings other than decompensated heart failure is currently limited.

Heart Failure After Myocardial Infarction: Clinical Implications and Treatment

“…However, it is important to note that despite hemodynamic improvement with dopamine, dobutamine, and levosimendan use, no increase in survival was observed. 18 The use of intra-aortic balloon counterpulsation (IABP) in cardiogenic shock, when not quickly reversed by pharmacologic therapy, is recommended. IABP reduces systolic overload, increases diastolic pressure, and therefore, coronary perfusion, improving left systolic function.…”

Levosimendan Treatment During Orthotopic Heart Transplantation: Case Report

“…Bu yan et ki nin gö rül me yi şi ni has ta la rın SVB'nin yük sek olu şu na ve be ra be rin de kul lan dı -ğı mız va zo ak tif ilaç la ra bağ la ya bi li riz. 18 Tol ler ve ark.nın kalp trans plan tas yon la rın da le vo si men dan kul la nı mı nı öner dik le ri gi bi biz de kul lan dı ğı mız bu iki ol gu da le vo si men da nın has ta prog no zu na fay da lı ol du ğu nu dü şü nü yo ruz. 19 An cak ko nuy la ilgi li ge niş ya yın la ra ih ti yaç ol du ğu da açık tır.…”

Design, synthesis and antihypertensive screening of novel pyridazine substituted s-triazin-2-imine/one/thione derivatives

“…Pyridazines are important biologically active scaffolds, possessing antihypertensive 4 , cardiotonic 5 , analgesic 6 , anti-inflammatory 7 , antidepressant 8 , antibacterial 9 , anticancer 10 , nephrotopic drugs 11 , antithrombic 12 , diuretic 13 and anti-HIV 14 activities. Some pyridazine derivatives, such as bemoradan 15 , indolidan 16 , levosimendan 17 , pimobendan 18 , zardaverine 19 and imazodan 20 , have already appeared in the clinical market. Nitrogen containing heterocycles play an important role not only for life science industry but also in many other industrial fields related to special and fine chemistry.…”