Heart Failure After Myocardial Infarction: Clinical Implications and Treatment

Minicucci, Marcos F.; Azevedo, Paula Schmidt; Polegato, Bertha Furlan; Paiva, Sérgio Alberto Rupp de; Zornoff, Leonardo A. M.

doi:10.1002/clc.20922

Cited by 174 publications

(149 citation statements)

References 35 publications

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“…LV remodelling occurs in a quite significant number of AMI patients and is associated with development of heart failure, cardiac arrhythmias and a poor survival rate, therefore early identification of this consequence of AMI is clinically very important. 3,4,20 The process of LV remodelling begins immediately after the onset of acute MI. Along with the changes of the infarct zone and non-infarct area of the LV, activation of the neurohumoral system after AMI plays an important role in post-infarct remodelling development.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene

Žaliaduonytė-Pekšienė

Šimonytė

Lesauskaitė

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Introduction: The development of left ventricular remodelling after acute myocardial infarction is a predictor of heart failure and mortality. The purpose of the present study was to assess whether the polymorphism of angiotensinogen (AGT) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 (M235T) had effects on cardiac remodelling after acute myocardial infarction. Methods: One hundred and forty-one patients (mean age 56.4±11.1 years) with a first acute myocardial infarction were enrolled. Within 24-72 hours of the onset of the symptoms and at a four month period two-dimensional echocardiography was performed. Remodelling was defined as a 20% increase from the baseline in left ventricular end-diastolic volume. The genotypes of the study group were compared with the reference group (n=1010) genotypes. AGT M235T polymorphism was determined using polymerase chain reaction amplification. Results: At follow-up, 49 patients (34.7%) were classified as having left ventricular remodelling. Anterior localization of the infarct (p=0.008), leucocyte count at admission (p=0.040), global left ventricular longitudinal strain (p=0.021) and MM genotype of AGT (p=0.024) were independent predictors of ventricular remodelling after myocardial infarction. Conclusions: Anterior wall infarction, increased leucocyte count, decreased longitudinal strain of left ventricular and polymorphism of AGT M235T may predict remodelling after myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene

Žaliaduonytė-Pekšienė

Šimonytė

Lesauskaitė

et al. 2013

J Renin Angiotensin Aldosterone Syst

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“…This study reports the greater prevalence of heart failure in myocardial infarction patients. 9,14,[18][19][20] Higher incidence of heart failure and the mortality in myocardial infarction patients in Bundelkhand could be explained by the patients' late referral to emergency and cardiac care units, scared of diagnostic facilities, and limited access to cardiac care.…”

Section: Discussionmentioning

confidence: 99%

A case control study in BMC Sagar to identify the risk factors for heart failure in patients with recently diagnosed myocardial infarction

Pandey

2017

Int J Adv Med

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Background: This study was conducted to identify the risk factors for heart failure (HF) in recently diagnosed myocardial infarction (MI) patients in Bundelkhand region of Madhya Pradesh, India.Methods: In this hospital-based, case-control study, the participants were all new myocardial infarction patients hospitalized from April 2016 to March 2017 in Bundelkhand Medical College (BMC) and associated hospital Sagar, Madhya Pradesh. There were 1,691 new cases with heart failure and 6,764 patients without heart failure as controls. Controls were selected randomly as per incidence density sampling. Odds ratios (ORs) with a 95% confidence interval (CI) was calculated to identify potential risk factors, using conditional logistic regression models.Results: The mortality rate was 18.2% in the cases and (12.1%) in the controls (p<0.05). Important risk factors for heart failure were: stroke (OR, 2.00; 95% CI, 1.39 to 2.89), and right bundle branch block (RBBB) (OR, 2.86; 95% CI, 1.95 to 4.19). The factors significantly associated with heart failure Diabetes, hypertension, atrial fibrillation, ventricular tachycardia, and age. Incidence (p<0.05). Significant factor in women was diabetes (OR, 1.41; 95% CI, 1.05 to 1.88) while in men age, hypertension, and RBBB are important.Conclusions: This study might help to identify and monitor the predictive risk factors for heart failure in myocardial infarction patients. The type of risk factors was different in men and women.

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“…25 However, the true prevalence and relevance of diastolic dysfunction after MI remains to be elucidated. 26 LV systolic dysfunction in patients with stable coronary disease is attributed to myocardial ischemia or hibernation, or prior infarction. 27,28 HF during hospital stay should be distinguished from pre-existing HF reported by patients on admission, which was present in 2.6% of patients who developed HF in this study.…”

Section: 22mentioning

confidence: 99%

Incidence and impact on prognosis of heart failure in Middle Eastern patients undergoing percutaneous coronary interventions

et al. 2017

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Background: Heart failure (HF) is a serious complication of percutaneous coronary intervention (PCI) that adversely impacts survival and quality of life. Aims and Objectives: We sought to study the incidence of HF in Middle Eastern patients undergoing PCI and its impact on prognosis. Materials and Methods: The first Jordanian PCI Registry was a prospective multicenter study of PCI patients who were followed for one year. Patients who developed heart failure during hospitalization had their clinical and coronary angiographic profiles and adverse outcomes compared with those in patients who did not develop HF. Results: Of 2425 patients who had PCI, 194 (8.0%) developed HF during the hospital stay. Compared with patients who did not develop HF, those who developed HF were more likely to have diabetes mellitus, prior history of myocardial infarction (MI), elevated levels of cardiac biomarkers, ST-segment elevation MI and multivessel or left anterior descending coronary artery disease (all p values<0.05). Cardiac mortality was significantly higher among patients who developed HF compared with those who did not (5.2% vs. 0.4%; p<0.0001) and at one year (11.2% vs. 1.2%; p<0.001). Multivariate analysis showed that HF during hospital stay was an independent predictor of one-year cardiac mortality (Odds ratio 6.1, 95% CI 3.3-11.1, p<0.001). At one year, readmission rates for HF and ACS were higher among HF patients. Conclusions: Certain clinical and angiographic features were associated with higher incidence of HF among Middle Eastern patients who undergo PCI. HF was associated with higher risk of death and other adverse cardiac events during hospital stay and one year of follow up.

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Heart Failure After Myocardial Infarction: Clinical Implications and Treatment

Cited by 174 publications

References 35 publications

Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene

Left ventricular remodelling after acute myocardial infarction: Impact of clinical, echocardiographic parameters and polymorphism of angiotensinogen gene

A case control study in BMC Sagar to identify the risk factors for heart failure in patients with recently diagnosed myocardial infarction

Incidence and impact on prognosis of heart failure in Middle Eastern patients undergoing percutaneous coronary interventions

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