Levofloxacin Based Sequential and Triple Therapy Compared with Standart Plus Probiotic Combination for Helicobacter Pylori Eradication

Özdil, Kamil; Çalhan, Turan; Şahin, Abdurrahman; Şenateş, Ebubekir; Kahraman, Resul; Yuzbasioglu, Bilgehan; Demirdağ, Hakan; Demirsoy, Hüseyin; Sokmen, Mehmet

doi:10.5754/hge11075

Cited by 29 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From all the included trials, 29 used PPI-triple therapy [17]–[25], [27]–[29], [31]–[41], [43]–[46], [48], [49], three used sequential therapy [26], [30], [42] and one used bismuth-quadruple therapy [47]. These studies were undertaken in Argentina [25], Brazil [46], mainland China [41], [49], China (Taiwan) [21], Finland [23], France [38], Iran [43], [45], [47], Italy [17]–[20], [22], [26], [29], [30], [32], [42], [44], Japan [40], Korea [31], [35], Poland [27], [34], Romania [33], Turkey [28], [36], [37], [39], United Kingdom [24] and the United Arabian Emirates [48]. (Table 1)…”

Section: Resultsmentioning

confidence: 99%

“…Studies used different strains of probiotics with 13 applying Lactobacillus [17]–[20], [24], [26], [27], [30], [32], [34], [38], [40], [41], two using Bifidobacterium [36], [48], one using Bacillus clausii [22], five using Saccharomyces [20], [28], [33], [35], [39] and 15 using multistrain [20], [21], [23], [26], [29], [31], [32], [37], [42]–[47], [49]. Among those studies applying individual probiotic supplementation, four specific species were effective: Lactobacillus acidophilus (pooled RR = 1.235, 95% CI 1.090–1.400), Lactobacillus casei DN-114001 (pooled RR = 1.473, 95% CI 1.13–1.949), Lactobacillus gasseri (pooled RR = 1.192, 95% CI 1.028–1.382), Bifidobacterium infantis 2036 (pooled RR = 1.205, 95% CI 1.031–1.408).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Probiotics Supplementation on Helicobacter pylori Eradication Rates and Side Effects during Eradication Therapy: A Meta-Analysis

et al. 2014

View full text Add to dashboard Cite

BackgroundPrevious meta-analyses reported that probiotics improve the effectiveness of Helicobacter pylori (H. pylori) eradication during antibiotic therapy, while results regarding a possible reduction of side effects remained inconclusive. Moreover, the effectiveness of different strains of probiotics has not been studied so far. It is further conceivable that probiotics will produce additional effects only if antibiotics are relatively ineffective.MethodsThis meta-analysis includes eligible randomized controlled trials examining effects of probiotics supplementation on eradication rates (ER) and side effects, published up to May 2014. Sub-group analysis was performed to compare different probiotic strains and antibiotic therapies with different effectiveness in controls (ER <80% vs.>80%). Publication bias was assessed with funnel plots and Harbord's test. The quality of the trials was assessed with the Cochrane risk of bias tool.ResultsThirty-three RCTs involving a total of 4459 patients met the inclusion criteria in case of eradication rates of which 20 assessed total side effects in addition. Overall, the pooled eradication rate in probiotics supplementation groups was significantly higher than in controls (ITT analysis: RR 1.122, 95% CI 1.086–1.159, PP analysis: RR 1.114, 95% CI 1.070–1.159). Sub group-analysis could, however, confirm this finding only for four individual strains (Lactobacillus acidophilus, Lactobacillus casei DN-114001, Lactobacillus gasseri, and Bifidobacterium infantis 2036) and for relatively ineffective antibiotic therapies. There was a significant difference between groups in the overall incidence of side effects (RR 0.735, 95% CI 0.598–0.902). This result was, however, only confirmed for non-blinded trials.ConclusionsThe pooled data suggest that supplementation with specific strains of probiotics compared with eradication therapy may be considered an option for increasing eradication rates, particularly when antibiotic therapies are relatively ineffective. The impact on side effects remains unclear and more high quality trials on specific probiotic strains and side effects are thus needed.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Effect of Probiotics Supplementation on Helicobacter pylori Eradication Rates and Side Effects during Eradication Therapy: A Meta-Analysis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…While the effectiveness of probiotic supplementation in increasing eradication rates has been more consistently reported in clinical studies as well as meta-analyses (16,17,(22)(23)(24)(25)(26)(27)(28)(29)(30), there is inconsistency regarding side effects, with demonstration of benefit in terms of overall side effects in probiotics groups in some studies (26,27,30), but a lack of any significant change in others (16,22,23,25,28,29,35,36).…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of the demonstration of anti-H. pylori activity of probiotics such as Lactobacillus, Saccharomyces boulardii, and Bifidobacterium, in in vitro and experimental models of H. pylori infection (19), probiotics have been suggested to improve H. pylori eradication and reduce side effects during therapy (17,20,21). However, findings from clinical studies on the use of probiotics as an adjuvant therapy to H. pylori infection have been inconsistent, with the demonstration of reduced side effects of antibiotics and improved eradication rates in some studies (16,(22)(23)(24)(25)(26)(27)(28)(29)(30), while no significant effects of adjuvant probiotics on eradication rates (22,(31)(32)(33)(34)(35)(36) or side effects (26,27,30,31,32,33,(35)(36)(37) have been reported in other studies.…”

mentioning

confidence: 99%

Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance

Çekın

Şahintürk²,

Harmandar³

et al. 2017

Turk J Gastroenterol

View full text Add to dashboard Cite

“…This result was confirmed by another study that used high-dose PPI (i.e., esomeprazole 40 mg, bid) and high-dose levofloxacin (i.e., 500 mg, bid) and demonstrated an eradication rate of 93% at ITT and 95 PP [47] . Levofloxacin-containing sequential regimens have also been demonstrated to achieve cure rates higher than 90% by Molina-Infante et al [48] , who used levofloxacin 250 mg bid, and by Ozdil et al [49] , who used levofloxacin 500 mg bid.…”

Section: Modified Sequential Therapymentioning

confidence: 95%

Eradication ofHelicobacter pyloriinfection: Which regimen first?

Federico

Gravina

Miranda

et al. 2014

WJG

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is a well-known human pathogen that plays an essential role in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric malignancies. Although H. pylori is susceptible to several antimicrobials, this infection has proven challenging to cure because of the increasing prevalence of bacterial strains that are resistant to the most commonly used antimicrobials, particularly clarithromycin. An effective (i.e., > 90%) first-line therapy is mandatory for avoiding supplementary treatments and testing, and more importantly for preventing the development of secondary resistance. This study reviews the recent literature on first-line therapies for H. pylori. The eradication rates following standard triple therapy (a proton pump inhibitor plus amoxicillin and clarithromycin) for H. pylori infection are declining worldwide. Several first-line strategies have been proposed to increase the eradication rate, including extending the treatment duration to 14 d, the use of a four-drug regimen (bismuth-containing quadruple, sequential, and concomitant treatments), and the use of novel antibiotics, such as fluoroquinolones. However, the efficacy of these regimens is controversial. A first-line eradication regimen should be based on what works best in a defined geographical area and must take into account the prevalence of antimicrobial resistance in that region.

show abstract

Levofloxacin Based Sequential and Triple Therapy Compared with Standart Plus Probiotic Combination for Helicobacter Pylori Eradication

Abstract: Levofloxacin-based sequential therapy and levofloxacin based triple therapy were significantly superior to standard triple therapy plus probiotic.

Cited by 29 publications

References 0 publications

The Effect of Probiotics Supplementation on Helicobacter pylori Eradication Rates and Side Effects during Eradication Therapy: A Meta-Analysis

The Effect of Probiotics Supplementation on Helicobacter pylori Eradication Rates and Side Effects during Eradication Therapy: A Meta-Analysis

Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance

Eradication ofHelicobacter pyloriinfection: Which regimen first?

Contact Info

Product

Resources

About